DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and Smc1b

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_536718.1	Gene:	Smc1b / 140557	MGIID:	2154049	Length:	1248	Species:	Mus musculus

Alignment Length:	1314	Identity:	302/1314 - (22%)
Similarity:	549/1314 - (41%)	Gaps:	241/1314 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLH 66
            |::.::::.|||::.:.|:.|| ||...::|.|||||||...|:.||:.::.|:||.:..|.|:|
Mouse     3 HLELLLVENFKSWRGRQVIGPF-KRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKNIQELIH 66

  Fly    67 EG-TGARV-ISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAG 129
            .. ||..| .||.|.||:      :....||....|:|.....:|....|.|.|:..|..||:.|
Mouse    67 GAHTGKPVSSSASVTIIY------IEDSGEEKTFTRIIRGGCSEYHFGDKPVSRSVYVAQLENIG 125

  Fly   130 FSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYLK 194
            ........:|.||.:..::......|.:...|::.:..:....|.....|::.:...:......|
Mouse   126 IIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHFNVKK 190

  Fly   195 TIEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKIYNIE 259
            .:....:..:.||||.:.||      ..||      |||..|..|...||.  .:.:|..:.|.|
Mouse   191 NVAAERKHAKIEKEEAEHYQ------NLLE------ELKINKIQLMLFQLY--YNEEKINVLNTE 241

  Fly   260 IQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKE 324
            :::....:..|:..|...:...::.|::..:|..:.||..:|...::..   ||.:.....|:||
Mouse   242 LEQMDGNLSVVKDTLSHHENIFKAKKKDYGMLTRQLQQTAKELKSVEAI---LNQKRPQYIKAKE 303

  Fly   325 RADQELKNL---KVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQF- 385
            .....||.|   |..|.:.||:....:....|:..:..|..|..:..|::.:|...::||..:.
Mouse   304 NTSHHLKKLDLSKKLITDNEKQCSKQEDGIRALVAELADLDRAWKSFEKQMEEKILQKGRDIELE 368

  Fly   386 SSREDRDKWITNELKSISKQTRDKIAHHAKLVEDLKKDATSEKD-LGQKIEEH---SSELEQLRL 446
            :|:.||       .|.:.:|.|.|:....:.:|.|:.:..:||: |..:...|   ...|:|::.
Mouse   369 NSQLDR-------YKLLKEQVRRKVGIMTQQLEKLQWEQKAEKERLAFEKRRHGDTQGNLKQIKE 426

  Fly   447 QIDEHNK---KYYELKKT--------KDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSM 500
            ||:||.|   |..|..||        |.|.::::.|:...:::|::.    .||||.....|::.
Mouse   427 QIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALKKEIENTKSRMSEV----NEELSLIRNELQNA 487

  Fly   501 AGKPILNGCDSVRKVLDSFVERGGQSAEI----ARAY----YGPVIENFSCDKTIYTAVEVTAAN 557
                   |.|:...      :|..:.||:    .|.|    :|.:::  .| ..|:...:: |..
Mouse   488 -------GIDNHEG------KRQQKRAEVLEHLKRLYPDSVFGRLLD--LC-HPIHKKYQL-AVT 535

  Fly   558 RLFHH-----IVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQVK-IHDYPDDPDSIPM---ISK 613
            :||..     :|.||......::.:...:...| ||:.|:.|.:| |::...:.....|   :.|
Mouse   536 KLFGRYMVAIVVASEKIAKDCIRFLKAERAEPE-TFLALDYLDIKPINERLREIKGCKMMIDVIK 599

  Fly   614 LKYDEQHDKALRYIFGKTLICRNLERATELAKSTGLD---CVTLDGDQVSSKGSLTGGYFNTSRS 675
            .:: .|..|.::::.|..|:|..:|.|..:|.. |.:   .|.|||......|.::||..:....
Mouse   600 TQF-PQLKKVIQFVCGNGLVCETVEEARHIAFG-GPERRKAVALDGTLFLKSGVISGGSSDLKHK 662

  Fly   676 RL--------EMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVF 732
            .|        .::.||::...::.|..|.|.|        |.::..|.:.:|.|.|:...|::..
Mouse   663 ALCWDEKELHNLRDKRSQLVQELKELMKTLRK--------ETDLKQIQTLVQGTNTRLKYSQNEL 719

  Fly   733 EKVQ--------GEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTL 789
            |.::        .|...::.||:.|:.........:.:.:..:|........:|.::.|:....:
Mouse   720 EMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDEVEDDIFQDFCEEI 784

  Fly   790 SSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRK------------------NKLDNLL---- 832
            ..::.||.:  |..::: .|||.:   :|::||.:|                  |.:|.|.
Mouse   785 GVENIREFE--NKHVKQ-QQENDQ---KRLEFEKQKTRLNIQLEYSRNQLKKKLNNIDTLKTTIQ 843

  Fly   833 -----INNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVM---- 888
                 |:||.:..:|.::.::|:.|     |....|..|.:....|:|::..:||..|:|:
Mouse   844 KGKEDIDNLKKTEEECLKIVEELMV-----KQEQIKEVLATQSSNIEKIHIQIEEERKKVLAVDR 903

  Fly   889 EAVQLQKEL--------QQELETHVRKEKEAEENLNKDSK-----------------QLEKWSTK 928
            |..:||||:        |:.||.|         ||..|.|                 ::|...|:
Mouse   904 EVGKLQKEVVIIQGSLEQKLLEKH---------NLLLDCKVQDIDISLVLGSLEDIIEMELTETE 959

  Fly   929 ENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNI--FKELEK---------ANQH--LKKYNH 980
            .......|   .||.||:    .:|.|..|..||.:  .||:|.         |:|.  |.|...
Mouse   960 STQATADI---YEKEASI----QIDYSPLREDLKALQSDKEVEAHLTLLLQQVASQENTLLKTTA 1017

  Fly   981 VNKKALDQFLS----FSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTK 1041
            .|.:|.:...:    |.|..:.....::|..|..|:    .:.::.::.:|....|..::.:..:
Mouse  1018 PNLRAQENLKTVRDKFQESADVFEASRKEARICRQE----FEQVKRRRYDAFSQCFEHISVSIDQ 1078

  Fly  1042 VFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLV 1106
            ::|||....:....|..::.|...::            ||..:..........|:.||||:|.:.
Mouse  1079 IYKKLCRNNSAQAFLSPENPEEPYLD------------GISYNCVAPGKRFMPMDNLSGGEKCVA 1131

  Fly  1107 ALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELS-DTAQFITTTFRPELLENAHKFY 1170
            ||||:|::....||||::.||:|.|||..:...|::.|.|.| :..|.|..:.:.|....|....
Mouse  1132 ALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQSQEQFQMIIISLKEEFYSKADALI 1196

  Fly  1171 GVRFRNKVSHIDCV 1184
            ||    ...|.:|:
Mouse  1197 GV----YPEHNECM 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	300/1308 (23%)
		ABC_SMC3_euk	3..>159	CDD:213239	49/157 (31%)
		SMC_hinge	533..643	CDD:214944	26/122 (21%)
		TMPIT	678..>760	CDD:285135	17/89 (19%)
		CHD5	<780..>822	CDD:282299	8/41 (20%)
		P-loop_NTPase	<1088..1182	CDD:304359	32/94 (34%)
Smc1b	NP_536718.1	Smc	3..1199	CDD:224117	300/1305 (23%)
		ABC_SMC1_euk	4..>148	CDD:213242	48/150 (32%)
		DUF342	<421..492	CDD:302792	22/81 (27%)
		SMC_hinge	513..628	CDD:214944	25/120 (21%)
		ABC_SMC1_euk	<1112..1215	CDD:213242	33/99 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740