Protein Alignment SMC3 and Smc3

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_031816.2
• Gene: Smc3 / 13006
• MGIID: 1339795
• Length: 1217
• Species: Mus musculus
• Alignment Length: 1220
• Identity: 652/1220 - (53%)
• Similarity: 893/1220 - (73%)
• Gaps: 25/1220 - (2%)

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLL 65
            |:|||:|||||:||:|||:|:||..:|||:|||||||||||||||||||||||:|||||||.:||
Mouse     1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALL 65

  Fly    66 HEGTGARVISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAGF 130
            |||||.|||||:|||||||||||:||||||:.||||||||||||||:||:|.:|:|:||||||||
Mouse    66 HEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGF 130

  Fly   131 SSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKISEYLKT 195
            |.||||||||||||||||||.||.|||||||||||||||||||||::|::||:.|.|||:|.||.
Mouse   131 SRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKY 195

  Fly   196 IEDRLQTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKALDELQLQRKSSSDKKKIYNIEI 260
            ||:||.|||||||||.:||||||.||.|||..|..||.:|:..||||..:|::|.:|.:......
Mouse   196 IEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQ 260

  Fly   261 QKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKER 325
            |.|::|::|:::.::|.|.|:.:.|||:..|..|:|:.::::|||:|...||.||:.|:::.::|
Mouse   261 QDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKR 325

  Fly   326 ADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSRED 390
            ..:|.:.|...|.|::|||.:.:||:.::|.|||.....|....|:|.:|||||||||||:|:|:
Mouse   326 LLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEE 390

  Fly   391 RDKWITNELKSISKQTRDKIAHHAKLVEDLK-KDATSEKDLGQ--KIEEHSSELEQLRLQIDEHN 452
            |||||..||||:.:...||....|.:.:||: .:|..||:|.|  |:::   :|.:::.:::|.:
Mouse   391 RDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQ---DLNEVKARVEELD 452

  Fly   453 KKYYELKKTKDQHQSMRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLD 517
            :||||:|..||:.||.||.|||:|....|.|...:|:|.:..|.||:..||.||||.||:.|||:
Mouse   453 RKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLE 517

  Fly   518 SFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKL 582
            .| .|.|.:..:...|:|.|:.||.|:...||.|||||.||||:|||:|:...|:||.|.||:.|
Mouse   518 HF-RRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNL 581

  Fly   583 PGEVTFMPLNRLQVKIHDYPDDPDSIPMISKLKYDEQHDKALRYIFGKTLICRNLERATELAKST 647
            ||||||:|||:|.|:...||:..|:|||||||:|:.:.|||.:::||||||||::|.:|:||::.
Mouse   582 PGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAF 646

  Fly   648 GLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSK-LRNELKSTENNI 711
            .:||:||:|||||.:|:|||||::|.:||||:||...:...::.|.|.||:: ||..::...|.|
Mouse   647 TMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEI 711

  Fly   712 NSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSS 776
            :.::::||:.||:|.|.|...:.:..|::::||:..:.|:...||:|||...:|||.:|.||:.|
Mouse   712 DQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRES 776

  Fly   777 LEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRD 841
            |:|||..:|:|.||.:||:.:|.|||:||:|.|||::...:|::.|....:::..|..||.:|.|
Mouse   777 LKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLD 841

  Fly   842 ELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLEEIEKRVMEAVQLQKELQQELETHVR 906
            ::.|.|.|:...:....|....:||.:..||:|...:..|:::..:.:.....||||:.:|....
Mouse   842 QVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKN 906

  Fly   907 KEKEAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLGAVPL-VDPSYTRMSLKNIFKELEK 970
            .|||..:.:|.|:|:|||.:.::.||.:|.:||.:||..||::|. ....|..:|||.:|::||:
Mouse   907 MEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQ 971

  Fly   971 ANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQV 1035
            .|..||||:||||||||||::||||||||.:|:||||.|.:.|..|:..||::|.||||.||:||
Mouse   972 CNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQV 1036

  Fly  1036 AQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENS----------------DAFTGIGIRVS 1084
            ::||::||:||||.|...|::|..|.||.:.:.|.|.|                |.|||:|||||
Mouse  1037 SKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVS 1101

  Fly  1085 FTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSD 1149
            |||.:.|||||.||||||||||||||||:|||||||||||||||||||||.|||||::||.||:.
Mouse  1102 FTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAV 1166

  Fly  1150 TAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAKDFVEDDSTH 1199
            .||||||||||||||:|.|||||:|||||||||.:|.|.||||||||:||
Mouse  1167 HAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTH 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	635/1198 (53%)
Smc3	NP_031816.2	SMC_N	2..1197	CDD:426784	635/1198 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..268		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1059..1090		6/30 (20%)