DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC3 and SMC2

DIOPT Version :9

Sequence 1:	NP_523374.2	Gene:	SMC3 / 32627	FlyBaseID:	FBgn0015615	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_001036015.1	Gene:	SMC2 / 10592	HGNCID:	14011	Length:	1197	Species:	Homo sapiens

Alignment Length:	1367	Identity:	329/1367 - (24%)
Similarity:	588/1367 - (43%)	Gaps:	360/1367 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            ||||.||::|||||..:|.|..||...|.:.|.|||||||...:|.|:|. ...:.:|....|.|
Human     1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSDNR-----VPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNL 124
            :::...|.:..|.|.|.|||||.:     ..:..|....|:|:...:::|.:|........|.:|
Human    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   125 LESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEKI 189
            ..|.|.:.:||::::.||:|.::........|.::.|.||||:|:.:|..:...:.:.::|:::|
Human   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEI 195

  Fly   190 SEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLE-----YIRYETEL-KDTKKALDELQLQRKS 248
            ...|:  |:...|:::.|||...|.::.|..|.:|     ||.|:..| :|||....|
Human   196 KTILE--EEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAE------- 251

  Fly   249 SSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLN 313
                      |:::.|:|:..:|:.|.|..||:::                            ||
Human   252 ----------ELKEMQDKVIKLQEELSENDKKIKA----------------------------LN 278

  Fly   314 DEVQGDNKSKERADQE----LKNLKVTIAEREKELDDVKPKYEA---MKRKEEDCSRELQLKEQK 371
            .|::   :.::|.|:|    |::|:..:||.::    |..|.::   :|:|...|      :|.|
Human   279 HEIE---ELEKRKDKETGGILRSLEDALAEAQR----VNTKSQSAFDLKKKNLAC------EESK 330

  Fly   372 RKELYAKQGRGSQ-FSSREDRDKWITNELKSI---SKQTRDKIA---HHAKLV------------ 417
            ||||.......|: .:::|...|.||:.|.::   |.:..:.:|   .|...|
Human   331 RKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE 395

  Fly   418 -----------EDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNE 471
                       .|:.|..|..|....|::....||:..:.::.:.:..|     .|||      |
Human   396 ATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGY-----RKDQ------E 449

  Fly   472 LWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAE--IAR--- 531
            ......::.::|:...::|:..:....|:..|         |:.|...:.|..::.|  :||
Human   450 ALEAVKRLKEKLEAEMKKLNYEENKEESLLEK---------RRQLSRDIGRLKETYEALLARFPN 505

  Fly   532 ---AYYGPVIE-NFSC------------DKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKL 580
               ||..|... |.:|            |.:..||:|:.|..||::.:|::|..|.::| |..:|
Human   506 LRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLL-ERGEL 569

  Fly   581 KLPGEVTFMPLNRLQ--------VKIHDYPDDPDSIPM-ISKLKYDEQHDKALRYIFGKTLICRN 636
            |  ...|.:|||::.        :::......||::.: :|.::|..:..||:.::||.|.:|.|
Human   570 K--RRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDN 632

  Fly   637 LERATELA--KSTGLDCVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSK 699
            ::.|.::|  |......|||.||.....|:|:||             .|::..|.:.:|: :|..
Human   633 MDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG-------------ARSQAASILTKFQ-ELKD 683

  Fly   700 LRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRI----EQYRAPKERSL 760
            :::||:..||                            |:|.::|||..:    |:||
Human   684 VQDELRIKEN----------------------------ELRALEEELAGLKNTAEKYR------- 713

  Fly   761 AQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAF--TQRMQ--- 820
             |.|...|..|.....|:.:|:|   |:...| |.|:|.|...|    :|::|..  |:.:|
Human   714 -QLKQQWEMKTEEADLLQTKLQQ---SSYHKQ-QEELDALKKTI----EESEETLKNTKEIQRKA 769

  Fly   821 ---FEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKK------- 875
               :||.:||:.|             .:|.:|..::|.::||:..||:..::.|::|:
Human   770 EEKYEVLENKMKN-------------AEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEA 821

  Fly   876 VNSDLEEIE------KRVMEAV-QLQKELQQELETHVRKEKEAEENLNKD----SKQLEKWSTKE 929
            :..:|||::      |:.:||| :..|..:.::|....:..:.:|::||.    :||.|..:.::
Human   822 ITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQD 886

  Fly   930 NMLNEKIDECTE----------KIASLGAVPLVDPSYTRMSLKNIFK---ELE----KANQHLKK 977
            .::..|..|..:          ||..|.              .||.|   |.|    |.::.||.
Human   887 TVIKAKYAEVAKHKEQNNDSQLKIKELD--------------HNISKHKREAEDGAAKVSKMLKD 937

  Fly   978 YNHVN--------------------KKALDQFLSFSEQKEKLYR--------------------- 1001
            |:.:|                    |:|..:.....|.||||.|
Human   938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLM 1002

  Fly  1002 -RKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDE 1065
             :|..::....||...|:.|:.:|.:|:...:::|.::|..:|..|:| ||..::...
Human  1003 KKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLP-GANAMLAPP------- 1059

  Fly  1066 MEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQ 1130
                 |......|:..:|:......|  .:.:|||||:|||||:||.|:....|||.|:.||:|.
Human  1060 -----EGQTVLDGLEFKVALGNTWKE--NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDA 1117

  Fly  1131 ALDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTR-------EE 1188
            |||..|.:.:..|:......:|||..:.:..:..||:..:..:|.:.||.:...|:       :|
Human  1118 ALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKE 1182

  Fly  1189 AK 1190
            ||
Human  1183 AK 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	323/1347 (24%)
		ABC_SMC3_euk	3..>159	CDD:213239	52/161 (32%)
		SMC_hinge	533..643	CDD:214944	34/131 (26%)
		TMPIT	678..>760	CDD:285135	16/85 (19%)
		CHD5	<780..>822	CDD:282299	13/49 (27%)
		P-loop_NTPase	<1088..1182	CDD:304359	34/93 (37%)
SMC2	NP_001036015.1	Smc	1..1168	CDD:224117	325/1349 (24%)
		ABC_SMC2_euk	1..>172	CDD:213240	57/170 (34%)
		Uds1	<193..287	CDD:292096	30/143 (21%)
		L_lactis_ph-MCP	252..>465	CDD:115336	52/264 (20%)
		SMC_hinge	522..639	CDD:214944	30/119 (25%)
		DUF342	<636..777	CDD:302792	48/198 (24%)
		DUF4200	740..841	CDD:290574	28/118 (24%)
		P-loop_NTPase	<1074..1168	CDD:304359	34/95 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820