Protein Alignment SMC3 and SMC4

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_005487.3
• Gene: SMC4 / 10051
• HGNCID: 14013
• Length: 1288
• Species: Homo sapiens
• Alignment Length: 1283
• Identity: 304/1283 - (23%)
• Similarity: 577/1283 - (44%)
• Gaps: 214/1283 - (16%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67
            |..|:.|.||||..:.::.||.||.:.::|.|||||||...::.||.......:|.::...|:|.
Human    84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHN 148

  Fly    68 GTGARVI-SAYVEIIFD-----NSDNRVPIDKEEIFLRRVIGAKKDQ---YFLNKKVVPRNEVVN 123
            ....:.| |..||:.|.     ..|:...|.....::.|.  |.:|.   |.::.|.....:|.|
Human   149 SDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRT--ACRDNTSVYHISGKKKTFKDVGN 211

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMA-------TAADSYRLKLLREVAGTRVYDE------RKEES 175
            ||.|.|....:..:::.||::.|:|       |..|...|:.|.::.|....:|      |:.|.
Human   212 LLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEI 276

  Fly   176 LNLLRETDSKVEKISEYLKTIEDRLQTLEEEKEELKEY-----QKWDKTRRTLEYIRYETELKDT 235
            ||     :.:.||::. :|.:|.....||.||....|:     :.:.|.....:|..||.:
Human   277 LN-----EHRGEKLNR-VKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQ---- 331

  Fly   236 KKALDELQLQR-------KSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMT 293
             |.:.|::.|:       |..::|..|.:.|::...:.:||.:|.|.:..|.::..||:.:.|..
Human   332 -KRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDL 395

  Fly   294 EQQQLLREKTK-LDLTIVDLNDEVQGDNKSKERADQELKNL-------------KVTIAEREKEL 344
            |..| :|||.| .......|..::|   |.||:. :|.|::             :....|:|||.
Human   396 EDVQ-VREKLKHATSKAKKLEKQLQ---KDKEKV-EEFKSIPAKSNNIINETTTRNNALEKEKEK 455

  Fly   345 DDVKPK--YEAMKRKEEDCSRELQLKEQKRKEL--YAK---QGRGSQFSSREDRDKWITNELKSI 402
            ::.|.|  .:::|::.:...:|   ||.:.|||  ::|   :.|.....::.:.|.:::....::
Human   456 EEKKLKEVMDSLKQETQGLQKE---KESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAV 517

  Fly   403 SKQTRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQS 467
            |:.|:.|.|..| ..|.||:...:.:|:..|:.:...||:       |..|:..:|.:.:...:|
Human   518 SQLTKAKEALIA-ASETLKERKAAIRDIEGKLPQTEQELK-------EKEKELQKLTQEETNFKS 574

  Fly   468 MRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVE--RGGQSAEIA 530
            :.::|::            |.|.:::..|:....|           ||||:.::  :.|:...|
Human   575 LVHDLFQ------------KVEEAKSSLAMNRSRG-----------KVLDAIIQEKKSGRIPGI- 615

  Fly   531 RAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVES---EYEGTQILKEMNKLKLPGEVTFMPLN 592
               ||.:.:..:.|:....|:. :..:.|.:.:|:|   ..|....||..|    .|..||:.|:
Human   616 ---YGRLGDLGAIDEKYDVAIS-SCCHALDYIVVDSIDIAQECVNFLKRQN----IGVATFIGLD 672

  Fly   593 RLQV---KIHDYPDDPDSIPM---ISKLKYDEQHDKALRYIFGKTLICRNLERATELA--KSTGL 649
            ::.|   |:.:. ..|::.|.   :.|:| ||:..:|..:....||:..||::||.:|  |....
Human   673 KMAVWAKKMTEI-QTPENTPRLFDLVKVK-DEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRW 735

  Fly   650 DCVTLDGDQVSSKGSLTGGYFNTSRSRL------------------EMQ---KKRTEYTSQIAEF 693
            ..|||.|..:...|::|||.....:.|:                  ::|   ||..:...|..:.
Human   736 RVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQL 800

  Fly   694 EKKLSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPK-- 756
            |:::.|||:..:...|.:....:.:|:...::       |.:..:::.::..::.    .||.
Human   801 EERVVKLRHSEREMRNTLEKFTASIQRLIEQE-------EYLNVQVKELEANVLA----TAPDKK 854

  Fly   757 -----ERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIRRLNQENKEAFT 816
                 |.:::..|...:::......:|||:|: |.:|:...:..::....|.:.::|::..|..:
Human   855 KQKLLEENVSAFKTEYDAVAEKAGKVEAEVKR-LHNTIVEINNHKLKAQQDKLDKINKQLDECAS 918

  Fly   817 QRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSAEKRIKKVNSDLE 881
            ...:.:|.....|    .||.:.:|.:::..:||  :|.::::::...||.|.|.:..:|..:..
Human   919 AITKAQVAIKTAD----RNLQKAQDSVLRTEKEI--KDTEKEVDDLTAELKSLEDKAAEVVKNTN 977

  Fly   882 EIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDS----KQLEKWSTKENMLNEKIDECTEK 942
            ..|:.:.|..:..:.|.|||:.    .:|.|..|.||:    .:||:........|.||....::
Human   978 AAEESLPEIQKEHRNLLQELKV----IQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKE 1038

  Fly   943 IASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKL-----YRR 1002
            |:.:...|:.|.....:|:.:. ::||.    :|..:.:..:.........|.|..|     |::
Human  1039 ISKISLHPIEDNPIEEISVLSP-EDLEA----IKNPDSITNQIALLEARCHEMKPNLGAIAEYKK 1098

  Fly  1003 KEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLIL--KTKDNE--- 1062
            ||||.:  |::      .|:.|:...:.:|||..::..|  ::|....|||.|:  |.|:|.
Human  1099 KEELYL--QRV------AELDKITYERDSFRQAYEDLRK--QRLNEFMAGFYIITNKLKENYQML 1153

  Fly  1063 --GDEMEKE-VENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYL 1124
              |.:.|.| |::.|.|:. ||..|....:...:::..||||:|:|.:|||:|::....|.|.|.
Human  1154 TLGGDAELELVDSLDPFSE-GIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYF 1217

  Fly  1125 FDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGV 1172
            .||||.|||..:...||..|:|.:..||||..:.|..:.|.:.:..|:
Human  1218 MDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGI 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	304/1283 (24%)
SMC4	NP_005487.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		SMC_N	83..1274	CDD:426784	304/1283 (24%)