DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC3 and smc2

DIOPT Version :9

Sequence 1:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster
Sequence 2:XP_002936738.3 Gene:smc2 / 100486893 XenbaseID:XB-GENE-5826169 Length:1202 Species:Xenopus tropicalis


Alignment Length:1309 Identity:321/1309 - (24%)
Similarity:582/1309 - (44%) Gaps:269/1309 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64
            ||:|.|||.|||||..:|.:..||...|.:.|.|||||||...:|.|:|. ...|.:|....|.|
 Frog     1 MHVKSIIIDGFKSYAQRTEINGFDPLFNAITGLNGSGKSNILDSICFLLGISNLTQVRASNLQDL 65

  Fly    65 LHEGTGARVISAYVEIIFDNSDNR-VPIDKE---EIFLRR--VIGAKKDQYFLNKKVVPRNEVVN 123
            :::...|.:..|.|.|.|||.|.: .|:..|   ||.:.|  |||. :::|.:|........|.:
 Frog    66 VYKNGQAGITKATVSITFDNYDKKQSPLGFEAHDEITVTRQVVIGG-RNKYLINGVNANNTRVQD 129

  Fly   124 LLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKVEK 188
            |..|.|.:.:||::::.||:|.::........|.::.|.||||:|:.:|..:...:.:.::|:::
 Frog   130 LFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKIAAQKTIEKKEAKLKE 194

  Fly   189 ISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLE-----YIRY------ETELKDTKKALDEL 242
            |...|:  |:...|:.:.|||...|.::.|..|.:|     ||.|      ||:::..:      
 Frog   195 IQTILE--EEITPTIHKLKEERSSYLEYQKIMREIEHLSRLYIAYQFVCAEETKVRSAE------ 251

  Fly   243 QLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDL 307
                            |:::.|:.|..:|..:.|.::||:...:|.:.|         ||.:   
 Frog   252 ----------------ELKEMQDSILKLQDTMAENERKVKELGKEIAEL---------EKLR--- 288

  Fly   308 TIVDLNDEVQGDNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKR 372
                 :.||.|          .|::|:..:||.::  .|.|.: .|:..|:::    ::.:|:||
 Frog   289 -----DQEVGG----------ALRSLEEALAEAQR--SDTKVQ-SALDLKKQN----MKAEEKKR 331

  Fly   373 KELYAKQGRGSQ-FSSREDRDKWITNELKSISKQTRDKIA--------HHAKLVEDLKKDATSEK 428
            |||.......:: .:::|...|.||:.|.|: ::|..|.|        |...:...|..:...|:
 Frog   332 KELVKSMEEDAKALTAKEKEVKKITDSLSSL-QETSQKDAEALTGAQQHFNAVSAGLSSNEDGEE 395

  Fly   429 D--LGQ------KIEEHSSELEQLRLQI----DEHNKKYYELKKTKDQHQSMRNELWRKETQMTQ 481
            .  .||      :|.:..:|.:|.::::    .|...|..|:|| .|......||.:....:..:
 Frog   396 ATLAGQMMACKNEISKAETEAKQAQMKLKHAQQELKTKQAEVKK-MDSGYKKDNEAFEAVKKSKE 459

  Fly   482 QLQTHKEELS----RADQALRSMAGKPILNGCDSVRKVLDSFV-------------ERGGQSAEI 529
            :|:...::|:    |.:|.|....|  :....:.:|:..:|.:             |:...|:.:
 Frog   460 KLEVEMKKLNYEDGREEQLLEKRRG--LSRDVNRLREAYESLMARFPNLQFEYKDPEKNWDSSRV 522

  Fly   530 ARAYYGPVIENFSC-DKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNR 593
            .    |.|....|. |.:..||:||.|..||::.:|::|..|.::|:   |.:|....|.:|||:
 Frog   523 K----GLVASLISVKDVSTATALEVVAGGRLYNVVVDTEVTGKKLLE---KGELKRRFTIIPLNK 580

  Fly   594 LQ--------VKIHDYPDDPDSIPM-ISKLKYDEQHDKALRYIFGKTLICRNLERATELA--KST 647
            :.        |.:.......|::.: :|.:.|:.:..||:.|:||.||:|..::.|.::.  :..
 Frog   581 ISARCLGKDTVNVAKNLVGADNVHLALSLVGYESELQKAMEYVFGTTLVCDTMDNAKKVTFDRKI 645

  Fly   648 GLDCVTLDGDQVSSKGSLTGGYFNTSRSRL-----------EMQKKRTEYTSQIAEFEKKLSKLR 701
            ....|||.||....:|:|:||..:.:.|.|           |::.|.|    |:.|.||:|..|:
 Frog   646 MTKTVTLGGDTFDPQGTLSGGARSQNASVLAKLQELKHVQEELRAKET----QLQEVEKELMSLK 706

  Fly   702 N------------ELKSTE-----------------NNINSIVSEMQKTETKQGKSKDVFEKVQG 737
            |            |:||.|                 ..::::...::.:|....|:|:|..|.:.
 Frog   707 NTVERYRQLKQQWEMKSEEADLLQTKLQQSSYHKQQEELDTLKQTIEGSEETLKKTKEVQMKAEE 771

  Fly   738 EIRLMKEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQELMSTLSSQDQREIDQLND 802
            :.::::.::...|   |.:||.|.:.:..|:.         |:.|.:..:....:.|:|:|..  
 Frog   772 KFKVLEHKMKNAE---AERERELKEAQQKLDG---------AKKKADASNKKMKEKQQEVDAF-- 822

  Fly   803 DIRRLNQENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELV 867
             :..|.:..:|..|.:.|.||                .||.::|.||        :.:|..:|:.
 Frog   823 -VLELEELKREQTTYKQQIEV----------------VDEAMKAYQE--------QADNMASEVA 862

  Fly   868 SAEKRIKKVNSDL-----------EEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQ 921
            ..::.:||...:|           :||:.:..||.:| :|...:|:.   |.||.|.|::|..|.
 Frog   863 KNKESVKKAQEELAKQKEIIMGHDKEIKTKSAEAGKL-RENNNDLQL---KIKELEHNISKHKKD 923

  Fly   922 LEKWSTK-ENMLNEKIDECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKY------- 978
            ....:.| ..|||:     .|.|||  ...|...:.|....|.  ...::|.|.|:|.       
 Frog   924 SADAAAKVAKMLND-----YEWIAS--EKHLFGQANTAYDFKT--NNPKEAGQRLQKLQEKKEKL 979

  Fly   979 -NHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKV 1042
             .:||.:|::......|:...|.::|..::....||...|:.|:.:|.||:...:::|.::|..:
 Frog   980 GRNVNMRAMNMLTQAEERYNDLMKKKRIVENDKSKILTTIEELDQKKNEALNIAWQKVNKDFGSI 1044

  Fly  1043 FKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVA 1107
            |..|:| ||..::...            |......|:..:|:......|  .:.:|||||:||||
 Frog  1045 FSTLLP-GANAMLAPP------------EGQSVLDGLEFKVALGNTWKE--NLTELSGGQRSLVA 1094

  Fly  1108 LALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGV 1172
            |:||.::....|||.|:.||:|.|||..|.:.:..|:......:|||..:.:..:..||:..:..
 Frog  1095 LSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFRHSQFIVVSLKDGMFNNANVLFKT 1159

  Fly  1173 RFRNKVSHI 1181
            :|.:.||.:
 Frog  1160 KFVDGVSTV 1168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 319/1305 (24%)
ABC_SMC3_euk 3..>159 CDD:213239 56/162 (35%)
SMC_hinge 533..643 CDD:214944 34/119 (29%)
TMPIT 678..>760 CDD:285135 23/110 (21%)
CHD5 <780..>822 CDD:282299 8/41 (20%)
P-loop_NTPase <1088..1182 CDD:304359 33/94 (35%)
smc2XP_002936738.3 Smc 1..1168 CDD:224117 321/1307 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D119789at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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