Protein Alignment SMC3 and smc1b

DIOPT Version :10

• Sequence 1: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: XP_031753497.1
• Gene: smc1b / 100145425
• XenbaseID: XB-GENE-997265
• Length: 1242
• Species: Xenopus tropicalis
• Alignment Length: 1348
• Identity: 312/1348 - (23%)
• Similarity: 555/1348 - (41%)
• Gaps: 307/1348 - (22%)

  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLH- 66
            :||:||:.|||:..:.|:.|| .|.|.|:|.|||||||...|..||:.::..:||....:.|:|
 Frog     4 MKQLIIENFKSWGGRQVIGPF-LRFNCVIGPNGSGKSNLMDAFSFVMGEKPANLRVRNIRQLIHG 67

  Fly    67 ------EGTGARVISAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLL 125
                  ..|.|||:..|.|   :|.:.|.       |.|.::| ...:|.::.|.|.|:..|..|
 Frog    68 ANVGKPMSTTARVVLVYSE---ENGEERQ-------FSRIIVG-DSSEYRIDGKPVGRSTYVMEL 121

  Fly   126 ESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGT-RVYDE-RKEESLNLLRETDSK--- 185
            |..|........:|.||::..:|......|..|..:::.: .:.|| .|::.|.|..|.|::
 Frog   122 ERIGIIVKARNCLVFQGEVESLAMKKPRERTHLFEQISNSWELADEYEKKKKLMLQAEEDAQFCY 186

  Fly   186 -------VEKISEYLKTIE-DRL----QTLEEEKEELKEYQKWDKTRRTLEYIRYETELKDTKKA 238
                   |::....|:..| ||.    |.|:|.|.||:.||.:...|:          |:...::
 Frog   187 NKKKNAAVQRKHATLEKAEADRYKALQQNLKETKVELQLYQLFHNERK----------LESVVRS 241

  Fly   239 LDELQLQRKSSSDKKKIYNIEIQKAQEKIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKT 303
            |:|.|      ||..:      ||.|         |..|:..::|.|.|......:.||:.:|..
 Frog   242 LEEKQ------SDANR------QKEQ---------LVRAESALKSEKAELGRCTRDLQQIEKEIK 285

  Fly   304 KLDLTIVDLNDEVQGDNKSKERADQELKNL---KVTIAEREK--------------ELDDVKPKY 351
            ..::::..|..:.   .|:||.....||.:   |..:|..||              |::|::..:
 Frog   286 VQEVSLSHLRPQF---IKAKENTAHHLKKVETAKKNVANNEKQCHKLEQDKSELETEIEDIETAW 347

  Fly   352 EAMKRK-EEDCSR---ELQLKEQKRKELYAKQGRGSQFSSREDRDKWITNELKSISKQTRDKIAH 412
            ...:|| |||..|   :::|:|.:|::.            ||.:::  .|:..::.:|..|::..
 Frog   348 RLFERKVEEDRQRRLGDIELEESQREQY------------RELKEE--ANKESAVLRQQLDRLQW 398

  Fly   413 HAKLV-EDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQSMRNELWRKE 476
            ..|.. |.|:...|.:|:: |..::|..|      ||:||||:..:|::..:.......|...:|
 Frog   399 EQKSAQEKLEFVLTRQKEV-QVNKKHVEE------QIEEHNKRIEKLEEYINTCLKSIEEQRPQE 456

  Fly   477 TQMTQQLQTHKEELSRADQALRSMAGK------PILNGCDSVRK--VLDSFVERGGQSAEIARAY 533
            .|:..:::..|:.:...::.|.|:.|:      ....|....||  ||:| ::|....|...|.:
 Frog   457 EQLAGEIKASKQRMVEINEQLNSIVGELQNARIDFHEGSRQKRKAEVLES-MKRMYPDAVFGRLF 520

  Fly   534 --YGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQV 596
              ..|:.:.:   :...|.|.....|.:....|:...:..:.|||    :.....||:.|:.|.:
 Frog   521 ELCHPIHKKY---QLAVTKVFGKYMNAIIVSTVQVARDCVKFLKE----ERAEPETFLALDYLDI 578

  Fly   597 K--------IHDYPDDPDSIPMIS-KLKYDEQHDKALRYIFGKTLICRNLERATELA--KSTGLD 650
            |        |.......|.|..:| .||      |.::::.|..|:|..::.|..:|  ....|.
 Frog   579 KQINEKLREIKGAKMMVDVIQTVSAPLK------KVIQFVCGNGLVCDTVKEAKRIAFDGPERLK 637

  Fly   651 CVTLDGDQVSSKGSLTGGYFNTSRSRLEMQKKRTEYTSQIAEFEKKLSKLRNELKSTENNINSIV 715
            .|.|||......|.::||     .|.|..:.||.:        ||::    ||||...:.:.:.:
 Frog   638 AVALDGTLFLKSGVISGG-----SSDLRYKAKRWD--------EKEI----NELKEKRDALMAEL 685

  Fly   716 SEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQC---KASLESMTSTKSSL 777
            .|:.|.:.::...|.:..::||....||.....:|   ..|::.||.|   |:.|:|..:..:|.
 Frog   686 KELIKLQRRESDLKQLQAQLQGTQTRMKYSQSEVE---VVKKKHLANCSMEKSRLDSELANFASQ 747

  Fly   778 EAELKQEL--MSTLSSQDQREIDQLND-------------DIRRLN----QENKEAFTQRMQFEV 823
            ...|::||  ..|.....|.:::|:.|             :||...    |:.:|...:|::|:.
 Frog   748 LTMLREELDVHGTKIGDIQEQMNQVEDRVFKDFCEAIGVPNIRAYEEEYVQQQQEMDKKRLEFDN 812

  Fly   824 RKNKLD---NLLINNLFRRRDELIQALQEISVED-----RKRKLNNC------------------ 862
            :|.:|.   ..:...|.:.|..:.::.|.:..|:     .|::...|
 Frog   813 QKTRLGIQLEYIRGQLEKGRSNIDKSKQTLQKEEGDKVRLKKEEEQCMKAVDKAMAQQQQFKNNF 877

  Fly   863 ---KTELVSAEKRIKKVNSDL----EEIEKRVMEAVQLQKELQQ--------------------- 899
               |:|:..|:|::::....|    .|:.|:..||..::..::|
 Frog   878 TFKKSEVADAQKKVEEARKALLNVNREMSKKQKEAAVIENSVEQKKIERHNLLLDCKVQDIQIIL 942

  Fly   900 -----------ELETHVRKEK------EAEENLNKDSKQLEKWSTKENMLNEKIDECTEKIASLG 947
                       ||:|.....:      |.|.|:..|.:.|.|  ..::::.:|  |.:.::.:|.
 Frog   943 LTGSLDDITEIELDTETESTQATADIYEREGNIQIDYRGLRK--DLKSLVTDK--EISAELMTLR 1003

  Fly   948 AVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYRRKEELDIGDQK 1012
            ...:...:....:..|: |.|||.:....|:    ::|.|.| ..|.:|.||.|.:
 Frog  1004 QETITLENTLLKTAPNL-KALEKLHSVRDKF----QEAADAF-EASRKKAKLCRNE--------- 1053

  Fly  1013 IHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEMEKEVENSDAFT 1077
                .:.::.::.|.....|..|.....:::|||....:....|..::.|...:|
 Frog  1054 ----FEQVKKRRYELFSRCFEHVCVAIDQIYKKLCRNPSAQAFLSPENPEEPYLE---------- 1104

  Fly  1078 GIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMHRKAVAN 1142
            ||....|..|  .....|:.||||:|::.||||:|:|....||||::.||:|.|||..:...|.:
 Frog  1105 GIAYNCSAPG--KRFMSMDNLSGGEKAVAALALVFAIHSFRPAPFFILDEVDAALDNSNIGKVTS 1167

  Fly  1143 MIHELS-DTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEA 1189
            .|.|.| :..|.:..:.:.|....|....||          |..:|||
 Frog  1168 YIREESREQFQVVVISLKEEFYSRADALIGV----------CAEQEEA 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_523374.2	SMC_N	2..1180	CDD:426784	308/1337 (23%)
smc1b	XP_031753497.1	SMC_N	3..1198	CDD:481474	306/1329 (23%)