DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33160 and KLKB1

DIOPT Version :9

Sequence 1:	NP_788456.1	Gene:	CG33160 / 326265	FlyBaseID:	FBgn0053160	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	243	Identity:	82/243 - (33%)
Similarity:	124/243 - (51%)	Gaps:	38/243 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RIIGGHVSSIKEEKY----LVQVTTSEELCGGSLVKPRWVITAAHCVYNKNKND-FKIYGGASNQ 92
            ||:||..||..|..:    .|::|....||||||:..:||:|||||.......| ::||.|..|.
Human   401 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNL 465

  Fly    93 AG-----PYAVIRTVDYIAIRPDFNRKTLNMDVAALRLNSDMIGANIETIPLAAQSVPARALVK- 151
            :.     |::.|:.   |.|..::.....|.|:|.::|.:.:.....:. |:...|....:.:.
Human   466 SDITKDTPFSQIKE---IIIHQNYKVSEGNHDIALIKLQAPLNYTEFQK-PICLPSKGDTSTIYT 526

  Fly   152 ---VSGWGFLTADATKTAERVHSVL----VPMWSRASCVSAFRGIHRITRSMVCAARLYK---KD 206
               |:||||     :|....:.::|    :|:.:...|...::. ::||:.||||.  ||   ||
Human   527 NCWVTGWGF-----SKEKGEIQNILQKVNIPLVTNEECQKRYQD-YKITQRMVCAG--YKEGGKD 583

  Fly   207 SCDGDSGGPLV--YRG--QLAGIVSFGYGCA-SALPGIYTSVPEIRDW 249
            :|.||||||||  :.|  :|.||.|:|.||| ...||:||.|.|..||
Human   584 ACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDW 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33160	NP_788456.1	Tryp_SPc	33..249	CDD:214473	80/241 (33%)
CG33160	NP_788456.1	Tryp_SPc	34..253	CDD:238113	81/242 (33%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	82/243 (34%)
		Tryp_SPc	402..632	CDD:238113	81/242 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910