DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGBE and Mal-A4

DIOPT Version :9

Sequence 1:	NP_788342.1	Gene:	AGBE / 326264	FlyBaseID:	FBgn0053138	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_610381.1	Gene:	Mal-A4 / 35827	FlyBaseID:	FBgn0033294	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	112/519 - (21%)
Similarity:	173/519 - (33%)	Gaps:	213/519 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 ASFGYQVTSFYAASSRYGNPEQLKRMIDVAHSHGLFVLLDVVHSHAS-------------KNVQD 283
            |.|||.::.|.|....:|..|..:.|:..|...|:.::||.|.:|:|             :..:|
  Fly    78 ADFGYDISDFKAVDPLFGTMEDFENMVSRAKELGVKIILDFVPNHSSDECDWFLRSAAGEEEYKD 142

  Fly   284 ------GLNQFDGTN-------SCF------FHDGARGEHSLWDSRL----FNYVEYEVLRFLLS 325
                  |....|||.       |.|      :|:| |.|:.|.....    ||: ...|:|..::
  Fly   143 YYMWHPGFLDEDGTRRPPTNWVSVFRGSAWEWHEG-RQEYYLHQFHKKQPDFNF-RNPVVREEMN 205

  Fly   326 N-LRWWHDEYNFDGYRFDGVTSMLYHSRGIGEGFSGDY-----NEYFGLNVDTDALNYLGLANHL 384
            | ||:|. |...||:|.|.:    ||:..|....:|:|     |::..   |.|...|    .|.
  Fly   206 NVLRFWL-EKGVDGFRVDAI----YHAFEIEADENGNYPDEPRNDWTN---DPDEYGY----THK 258

  Fly   385 LHTIDSRIITIAEDVSGMPTLCRPVSEGGIGFDYRLGMAIPDKWIELLKE-QSDDEWDMGNLVHT 448
            ::|:|            .|.....|.|                |.::|:: |:|:.
  Fly   259 IYTVD------------QPETPHLVYE----------------WRQILEQFQADNG--------- 286

  Fly   449 LTNRRWMENTVAYAESHDQALVGDKTIAFWLMDKEMYTHMSTLSDSSVIIDRGLALHKMIRLITH 513
                                  ||:.|   ||       :.|.|.              |.::.|
  Fly   287 ----------------------GDERI---LM-------VETWSP--------------IEIVMH 305

  Fly   514 ALGGE----AYLNFMGNEFGHPEWLDFPRVGNNDSYHYARRQWNLVDDDLLKYKYLNEFDRAMNE 574
            ..|.|    |.:.|           :|..:.|   .||        |.|...|:||      :|
  Fly   306 YYGNETADGAQIPF-----------NFQLISN---LHY--------DSDAYHYEYL------IN- 341

  Fly   575 AEERYGWLHSGPA-----WVSWKHEGDKIIAFERAGLVFVFNF----HPQQSFT--GYRVG---- 624
                 .||:..|.     ||...|:.:::.:...|..|.:||.    .|..|.|  |..:|
  Fly   342 -----NWLNLMPEGKSANWVIGNHDKNRVGSRFGADRVDLFNILLLTLPGCSITYQGEELGMLDG 401

  Fly   625 -TNWAGTYQAVLSSDDPLFGGH--NRIDANCKHPSNP---------EGY-AGRSNFIEVYTPSR 675
             .:|..|.      |.....|:  |.:| |.:.|:..         .|: .|.|.::.|.|..|
  Fly   402 YVSWEDTV------DPQACNGYEANYMD-NSRDPARTPMHWSDETMAGFTTGNSTWLPVSTDYR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGBE	NP_788342.1	GlgB	52..682	CDD:223373	112/519 (22%)
		E_set_GBE_euk_N	62..161	CDD:199884
		AmyAc_bac_euk_BE	167..570	CDD:200460	82/384 (21%)
		Alpha-amylase_C	588..683	CDD:280898	26/111 (23%)
Mal-A4	NP_610381.1	AmyAc_maltase	24..492	CDD:200467	112/519 (22%)
Mal-A4	NP_610381.1	Alpha-amylase	47..401	CDD:278554	98/453 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443590
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930