DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGBE and Gbe1

DIOPT Version :9

Sequence 1:	NP_788342.1	Gene:	AGBE / 326264	FlyBaseID:	FBgn0053138	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001093972.1	Gene:	Gbe1 / 288333	RGDID:	1309968	Length:	702	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	419/683 - (61%)
Similarity:	522/683 - (76%)	Gaps:	6/683 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAKDIEKLFETDGYLRPFEHEIRRRHGVLEDWLNKINQSEGGLDGFSTAYKHYGLHFQPDNSV 65
            :|:..::.:|.|.|.||:|:..:.:||:......|:.|.::|||:|.||..|:.:|:|...|..:
  Rat    22 LADVPELGRLLEIDPYLKPYAADFQRRYKKFNQVLHDIGENEGGIDKFSRGYESFGIHRCSDGGI 86

  Fly    66 IAREWAPGARDVYLTGDFNNWHWESHPFKKLDFGKWELHLPPNEDGSPAIKHLSEIKIIIRNHSG 130
            ..:||||||..|:|||:|:.|:..|||:|||::|||||::||.::.||.|.|.|::|::|.:.||
  Rat    87 YCKEWAPGAEGVFLTGEFSGWNPFSHPYKKLEYGKWELYIPPKQNKSPPIPHGSKLKVVITSKSG 151

  Fly   131 QLLDRLSPWAKYVVQPPKSANQGVNYKQYVWEPPSYERYQRQHPGPPRPKSLRIYECHVGIASQE 195
            ::|.|:||||||||:    .|..|||....|:|.:  .|:.:|..|.:|:||||||.||||:|.|
  Rat   152 EILYRISPWAKYVVR----ENNNVNYDWIHWDPEN--PYKFRHSRPKKPRSLRIYESHVGISSHE 210

  Fly   196 PRVGSYDEFADRIVPRIKRQGYNCIQVMAIMEHAYYASFGYQVTSFYAASSRYGNPEQLKRMIDV 260
            .::.||..|...::||||..||||||:|||||||||||||||||||:|||||||.||:||.::|.
  Rat   211 GKIASYKHFTSNVLPRIKDLGYNCIQLMAIMEHAYYASFGYQVTSFFAASSRYGTPEELKELVDT 275

  Fly   261 AHSHGLFVLLDVVHSHASKNVQDGLNQFDGTNSCFFHDGARGEHSLWDSRLFNYVEYEVLRFLLS 325
            ||..|:.|||||||||||||.:||||.||||:||:||.|.||.|.|||||||.|..:||||||||
  Rat   276 AHLMGIVVLLDVVHSHASKNSEDGLNMFDGTDSCYFHSGPRGTHDLWDSRLFIYSSWEVLRFLLS 340

  Fly   326 NLRWWHDEYNFDGYRFDGVTSMLYHSRGIGEGFSGDYNEYFGLNVDTDALNYLGLANHLLHTIDS 390
            |:|||.:||.|||:|||||||||||..|:|:||||||:|||||.||.|||.||.|||||.||:..
  Rat   341 NIRWWLEEYCFDGFRFDGVTSMLYHHHGMGQGFSGDYSEYFGLQVDEDALVYLMLANHLTHTMYP 405

  Fly   391 RIITIAEDVSGMPTLCRPVSEGGIGFDYRLGMAIPDKWIELLKEQSDDEWDMGNLVHTLTNRRWM 455
            ..|||||||||||.||.|.|:||.||||||.||||||||:||||..|::|:|||:|:||||||.:
  Rat   406 DSITIAEDVSGMPALCSPTSQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGNIVYTLTNRRHL 470

  Fly   456 ENTVAYAESHDQALVGDKTIAFWLMDKEMYTHMSTLSDSSVIIDRGLALHKMIRLITHALGGEAY 520
            |..||||||||||||||||:||||||.||||:||.|:..:.:||||:.||||||||||.||||.|
  Rat   471 EKCVAYAESHDQALVGDKTLAFWLMDAEMYTNMSVLAPFTPVIDRGIQLHKMIRLITHGLGGEGY 535

  Fly   521 LNFMGNEFGHPEWLDFPRVGNNDSYHYARRQWNLVDDDLLKYKYLNEFDRAMNEAEERYGWLHSG 585
            ||||||||||||||||||.|||:||||||||:||.|||||:||:||.|||.||..||..|||.:.
  Rat   536 LNFMGNEFGHPEWLDFPRKGNNESYHYARRQFNLTDDDLLRYKFLNNFDRDMNRLEETCGWLSAP 600

  Fly   586 PAWVSWKHEGDKIIAFERAGLVFVFNFHPQQSFTGYRVGTNWAGTYQAVLSSDDPLFGGHNRIDA 650
            .|:||.||||:|.|.||||||:|:|||||.:|:|.|||||...|.::.||.||...:|||.|:|.
  Rat   601 QAYVSEKHEGNKTITFERAGLLFIFNFHPSKSYTDYRVGTAMPGKFKIVLDSDAAEYGGHQRLDH 665

  Fly   651 NCKHPSNPEGYAGRSNFIEVYTPSRTAVVYARV 683
            :..:.:....:.||...:.||.|||.|::...|
  Rat   666 STDYFAEAFEHNGRPYSLLVYIPSRVALILQNV 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGBE	NP_788342.1	GlgB	52..682	CDD:223373	401/629 (64%)
		E_set_GBE_euk_N	62..161	CDD:199884	49/98 (50%)
		AmyAc_bac_euk_BE	167..570	CDD:200460	292/402 (73%)
		Alpha-amylase_C	588..683	CDD:280898	45/94 (48%)
Gbe1	NP_001093972.1	PLN02447	15..699	CDD:215246	419/683 (61%)
		E_set_GBE_euk_N	83..178	CDD:199884	49/98 (50%)
		AmyAc_bac_euk_BE	180..585	CDD:200460	293/406 (72%)
		Alpha-amylase_C	603..698	CDD:280898	45/94 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I566
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129
Inparanoid	1	1.050	830	1.000	Inparanoid score	I430
OMA	1	1.010	-	-		QHG54296
OrthoDB	1	1.010	-	-		D147330at33208
OrthoFinder	1	1.000	-	-		FOG0002879
OrthoInspector	1	1.000	-	-		oto97460
orthoMCL	1	0.900	-	-		OOG6_101128
Panther	1	1.100	-	-	LDO	PTHR43651
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2709
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980