Protein Alignment AGBE and GBE1

DIOPT Version :10

• Sequence 1: NP_788342.1
• Gene: AGBE / 326264
• FlyBaseID: FBgn0053138
• Length: 685
• Species: Drosophila melanogaster
• Sequence 2: NP_000149.4
• Gene: GBE1 / 2632
• HGNCID: 4180
• Length: 702
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 418/683 - (61%)
• Similarity: 524/683 - (76%)
• Gaps: 6/683 - (0%)

  Fly     1 MAEAKDIEKLFETDGYLRPFEHEIRRRHGVLEDWLNKINQSEGGLDGFSTAYKHYGLHFQPDNSV 65
            :|:..::.:|.|.|.||:|:..:.:||:......|..|.::|||:|.||..|:.:|:|...|..:
Human    22 LADVPELARLLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGL 86

  Fly    66 IAREWAPGARDVYLTGDFNNWHWESHPFKKLDFGKWELHLPPNEDGSPAIKHLSEIKIIIRNHSG 130
            ..:||||||..|:||||||.|:..|:|:||||:|||||::||.::.|..:.|.|::|::|.:.||
Human    87 YCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSG 151

  Fly   131 QLLDRLSPWAKYVVQPPKSANQGVNYKQYVWEPPSYERYQRQHPGPPRPKSLRIYECHVGIASQE 195
            ::|.|:||||||||:    ....|||....|:|.  ..|:.:|..|.:|:||||||.||||:|.|
Human   152 EILYRISPWAKYVVR----EGDNVNYDWIHWDPE--HSYEFKHSRPKKPRSLRIYESHVGISSHE 210

  Fly   196 PRVGSYDEFADRIVPRIKRQGYNCIQVMAIMEHAYYASFGYQVTSFYAASSRYGNPEQLKRMIDV 260
            .:|.||..|...::||||..||||||:|||||||||||||||:|||:|||||||.||:|:.::|.
Human   211 GKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDT 275

  Fly   261 AHSHGLFVLLDVVHSHASKNVQDGLNQFDGTNSCFFHDGARGEHSLWDSRLFNYVEYEVLRFLLS 325
            |||.|:.|||||||||||||..||||.||||:||:||.|.||.|.|||||||.|..:|:||||||
Human   276 AHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLS 340

  Fly   326 NLRWWHDEYNFDGYRFDGVTSMLYHSRGIGEGFSGDYNEYFGLNVDTDALNYLGLANHLLHTIDS 390
            |:|||.:||.|||:|||||||||||..|:|:||||||:|||||.||.|||.||.|||||:||:..
Human   341 NIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCP 405

  Fly   391 RIITIAEDVSGMPTLCRPVSEGGIGFDYRLGMAIPDKWIELLKEQSDDEWDMGNLVHTLTNRRWM 455
            ..|||||||||||.||.|:|:||.||||||.||||||||:||||..|::|:||::|:||||||::
Human   406 DSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYL 470

  Fly   456 ENTVAYAESHDQALVGDKTIAFWLMDKEMYTHMSTLSDSSVIIDRGLALHKMIRLITHALGGEAY 520
            |..:||||||||||||||::||||||.||||:||.|:..:.:||||:.||||||||||.||||.|
Human   471 EKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGY 535

  Fly   521 LNFMGNEFGHPEWLDFPRVGNNDSYHYARRQWNLVDDDLLKYKYLNEFDRAMNEAEERYGWLHSG 585
            ||||||||||||||||||.|||:||||||||::|.|||||:||:||.|||.||..|||||||.:.
Human   536 LNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAP 600

  Fly   586 PAWVSWKHEGDKIIAFERAGLVFVFNFHPQQSFTGYRVGTNWAGTYQAVLSSDDPLFGGHNRIDA 650
            .|:||.||||:||||||||||:|:|||||.:|:|.|||||...|.::.||.||...:|||.|:|.
Human   601 QAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDH 665

  Fly   651 NCKHPSNPEGYAGRSNFIEVYTPSRTAVVYARV 683
            :....|....:.||...:.||.|||.|::...|
Human   666 STDFFSEAFEHNGRPYSLLVYIPSRVALILQNV 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGBE	NP_788342.1	PLN02447	9..685	CDD:215246	417/675 (62%)
GBE1	NP_000149.4	PLN02447	2..699	CDD:215246	418/683 (61%)