Protein Alignment CG33128 and bace1

DIOPT Version :10

• Sequence 1: NP_787961.1
• Gene: CG33128 / 326263
• FlyBaseID: FBgn0053128
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001072485.1
• Gene: bace1 / 779940
• XenbaseID: XB-GENE-5787150
• Length: 502
• Species: Xenopus tropicalis
• Alignment Length: 377
• Identity: 92/377 - (24%)
• Similarity: 146/377 - (38%)
• Gaps: 102/377 - (27%)

  Fly    93 YYGLIGIGTPEQYFKVVFDTGSANLWVPSAQCLATDVACQQH----NQYNSSASSTFVSSGQNFS 153
            ||..:.:|||.|...::.||||:|..|.:|          .|    ..|:...|.|:....:...
 Frog    76 YYVEMRVGTPPQTLNILVDTGSSNFAVGAA----------PHPFLKRYYHRQHSRTYRDVRRGVY 130

  Fly   154 IQYGTGSVSGYLAIDTVTI----NGLAIANQTFGEAVSQPGASFTDVA-FDGILGMGYQQIAE-D 212
            :.|..|...|.|..|.|||    |....||..   |::.....|.:.: ::||||:.|.:||. |
 Frog   131 VPYTQGKWEGELGTDLVTIPHGPNVTVTANIA---AITDSDKFFINGSNWEGILGLAYAEIARPD 192

  Fly   213 NVVPPFYNLYEEGLIDEP----VFGFYLARNG--------SAVDGGQLTLGGTDQNLIAGEMTYT 265
            :.:.||:    :.|:.:.    :|...|...|        ||..||.:.:||.|.:|..|.:.||
 Frog   193 DTLEPFF----DSLVKQTRVPNIFSLQLCGTGFHFNESDTSASVGGSMVIGGIDPSLYIGSIWYT 253

  Fly   266 PVTQQGYWQFAVNNITWNGTVISSGC------QAIADTGTSLIAAPSAAYIQLNNLIGGVPIQGD 324
            |:.::.|::..:..|..||..:...|      ::|.|:||:.:..|...:              |
 Frog   254 PIRKEWYYEVIIVKIEINGQDLHMDCKEYNYDKSIVDSGTTNLRLPKRVF--------------D 304

  Fly   325 YYVPCSTVSS---------------------------LPVLTI----NIGGTNF--------YLP 350
            ..|.....:|                           .||:::    .:...:|        ||.
 Frog   305 AAVKSIKAASSTEKFPDGFWLGEQLVCWQEGTTPWHIFPVISLYLMGEVANQSFKITILPQQYLR 369

  Fly   351 PSVYIQTYTEGNYTTCMSTFTDIGTGFWILGDVFLGQYYSEFDFGQNRVGFA 402
            |...|.|..|..|...:|..| .||   ::|.|.:..:|..||....|:|||
 Frog   370 PVEDIATAQEDCYKFAVSQST-TGT---VMGAVIMEGFYVVFDRANKRIGFA 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33128	NP_787961.1	pepsin_retropepsin_like	83..403	CDD:472175	92/377 (24%)
bace1	NP_001072485.1	beta_secretase_like	73..438	CDD:133140	92/377 (24%)