Protein Alignment CG33128 and PGA4

DIOPT Version :10

• Sequence 1: NP_787961.1
• Gene: CG33128 / 326263
• FlyBaseID: FBgn0053128
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001073276.1
• Gene: PGA4 / 643847
• HGNCID: 8886
• Length: 388
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 161/417 - (38%)
• Similarity: 234/417 - (56%)
• Gaps: 42/417 - (10%)

  Fly     2 LKWLVLLTILALVSAEIHRIKIHKNQDHKNTRQHRKQAIQALK--LKYHQQDVVIIYDDGVPIYM 64
            :|||:||.::||....::::.:.:.:..:.|...|    ..||  ||.|.              :
Human     1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSER----GLLKDFLKKHN--------------L 47

  Fly    65 QPDYGY--DYPSQTSVDYTSEELGNSMNMYYYGLIGIGTPEQYFKVVFDTGSANLWVPSAQCLAT 127
            .|...|  .:.:.|.||  .:.|.|.::|.|:|.||||||.|.|.|||||||:||||||..|  :
Human    48 NPARKYFPQWEAPTLVD--EQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--S 108

  Fly   128 DVACQQHNQYNSSASSTFVSSGQNFSIQYGTGSVSGYLAIDTVTINGLAIANQTFGEAVSQPGAS 192
            .:||..||::|...|||:.|:.:..||.|||||::|.|..|||.:.|::..||.||.:.::||:.
Human   109 SLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSF 173

  Fly   193 FTDVAFDGILGMGYQQIAEDNVVPPFYNLYEEGLIDEPVFGFYLARNGSAVDGGQLTLGGTDQNL 257
            .....||||||:.|..|:.....|.|.|::.:||:.:.:|..||:.:..:  |..:..||.|.:.
Human   174 LYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS--GSVVIFGGIDSSY 236

  Fly   258 IAGEMTYTPVTQQGYWQFAVNNITWNGTVI--SSGCQAIADTGTSLIAAPSAAYIQLNNLIGGVP 320
            ..|.:.:.|||.:||||..|::||.||..|  :.|||||.||||||:..|::....:.:.||...
Human   237 YTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASE 301

  Fly   321 -IQGDYYVPCSTVSSLPVLTINIGGTNFYLPPSVYIQTYTEGNYTTCMSTF------TDIGTGFW 378
             ..||..|.||.:||||.:...|.|..:.:|||.|| ..:||   :|:|.|      |:.|. .|
Human   302 NSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI-LQSEG---SCISGFQGMNLPTESGE-LW 361

  Fly   379 ILGDVFLGQYYSEFDFGQNRVGFATLA 405
            ||||||:.||::.||...|:||.|.:|
Human   362 ILGDVFIRQYFTVFDRANNQVGLAPVA 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33128	NP_787961.1	pepsin_retropepsin_like	83..403	CDD:472175	140/328 (43%)
PGA4	NP_001073276.1	A1_Propeptide	19..45	CDD:462326	6/29 (21%)
		pepsin_A	66..386	CDD:133145	140/328 (43%)