Protein Alignment CG33128 and Bace2

DIOPT Version :10

• Sequence 1: NP_787961.1
• Gene: CG33128 / 326263
• FlyBaseID: FBgn0053128
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001002802.1
• Gene: Bace2 / 288227
• RGDID: 1303241
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 398
• Identity: 100/398 - (25%)
• Similarity: 174/398 - (43%)
• Gaps: 83/398 - (20%)

  Fly    58 DGVPIYMQPDYGYDYPSQTSVDYTS--EEL-GNSMNMYYYGLIGIGTPEQYFKVVFDTGSANLWV 119
            ||:.:.::       |::.:.::.:  :.| |:|...||..:: ||||.|..:::.||||:|..|
  Rat    58 DGLALALE-------PARATANFLAMVDNLQGDSGRGYYLEML-IGTPPQKVRILVDTGSSNFAV 114

  Fly   120 PSAQCLATDVACQQHNQYNSSASSTFVSSGQNFSIQYGTGSVSGYLAIDTVTI-NGLAIANQTF- 182
            ..|.....|      ..::|.:|||:.|.|...:::|..||.:|::..|.||| .|.   |.:|
  Rat   115 AGAPHSYID------TYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGF---NSSFL 170

  Fly   183 --------GEAVSQPGASFTDVAFDGILGMGYQQIAE---------DNVV-----PPFYNLYEEG 225
                    .|....||     :.::||||:.|..:|:         |::|     |..:::
  Rat   171 VNIATIFESENFFLPG-----IKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSM---- 226

  Fly   226 LIDEPVFGFYLARNGSAVDGGQLTLGGTDQNLIAGEMTYTPVTQQGYWQFAVNNITWNGTVISSG 290
                .:.|..|...||..:||.|.|||.:.:|..|::.|||:.::.|:|..:..:...|..::..
  Rat   227 ----QMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLD 287

  Fly   291 C------QAIADTGTSLIAAPSAAYIQLNNLIGG---VPIQGDYY-----VPCSTVSS-----LP 336
            |      :||.|:||:|:..|...:..:...:..   :|...|.:     :.|.|.|.     .|
  Rat   288 CREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFP 352

  Fly   337 VLTINIGGTN------FYLPPSVYIQTYTEGNYT-TCMSTFTDIGTGFWILGDVFLGQYYSEFDF 394
            .::|.:...|      ..:.|.:|||......:. .|........|...::|...:..:|..||.
  Rat   353 KISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDR 417

  Fly   395 GQNRVGFA 402
            .|.|||||
  Rat   418 AQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33128	NP_787961.1	pepsin_retropepsin_like	83..403	CDD:472175	97/371 (26%)
Bace2	NP_001002802.1	beta_secretase_like	85..446	CDD:133140	94/364 (26%)