DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33128 and BACE1

DIOPT Version :10

Sequence 1:NP_787961.1 Gene:CG33128 / 326263 FlyBaseID:FBgn0053128 Length:405 Species:Drosophila melanogaster
Sequence 2:NP_036236.1 Gene:BACE1 / 23621 HGNCID:933 Length:501 Species:Homo sapiens


Alignment Length:404 Identity:96/404 - (23%)
Similarity:165/404 - (40%) Gaps:77/404 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 GVPIYMQPDYGYDYPSQTSVDYTSEELG-------------NSMNMYYYGLIGIGTPEQYFKVVF 110
            |.|:      |...|.:|  |...||.|             ......||..:.:|:|.|...::.
Human    36 GAPL------GLRLPRET--DEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV 92

  Fly   111 DTGSANLWVPSAQCLATDVACQQHNQYNSSASSTFVSSGQNFSIQYGTGSVSGYLAIDTVTI-NG 174
            ||||:|..|.:|.....      |..|....|||:....:...:.|..|...|.|..|.|:| :|
Human    93 DTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHG 151

  Fly   175 LAIANQTFGEAVSQPGASFTDVA-FDGILGMGYQQIA--EDNVVPPFYNLYEEGLIDEPVFGFYL 236
            ..:..:....|:::....|.:.: ::||||:.|.:||  :|::.|.|.:|.::..:.. :|...|
Human   152 PNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQL 215

  Fly   237 ARNGSAVD--------GGQLTLGGTDQNLIAGEMTYTPVTQQGYWQFAVNNITWNGTVISSGC-- 291
            ...|..::        ||.:.:||.|.:|..|.:.|||:.::.|::..:..:..||..:...|  
Human   216 CGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKE 280

  Fly   292 ----QAIADTGTSLIAAPSAAYIQLNNLIGGVPIQ---------GDYYVPCSTVSS-----LPVL 338
                ::|.|:||:.:..|...:......|......         |:..| |....:     .||:
Human   281 YNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVI 344

  Fly   339 TINIGG--TN----------FYLPPSVYIQTYTEGNYTTCMSTFTDIGTGFWILGDVFLGQYYSE 391
            ::.:.|  ||          .||.|...:.|..:..|...:|. :..||   ::|.|.:..:|..
Human   345 SLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ-SSTGT---VMGAVIMEGFYVV 405

  Fly   392 FDFGQNRVGFATLA 405
            ||..:.|:|||..|
Human   406 FDRARKRIGFAVSA 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33128NP_787961.1 pepsin_retropepsin_like 83..403 CDD:472175 88/376 (23%)
BACE1NP_036236.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58 7/26 (27%)
beta_secretase_like 72..437 CDD:133140 87/360 (24%)
Interaction with RTN3 479..501
DXXLL. /evidence=ECO:0000269|PubMed:15886016 496..500
Blue background indicates that the domain is not in the aligned region.

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