Protein Alignment CG33128 and bace2

DIOPT Version :10

• Sequence 1: NP_787961.1
• Gene: CG33128 / 326263
• FlyBaseID: FBgn0053128
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 368
• Identity: 92/368 - (25%)
• Similarity: 158/368 - (42%)
• Gaps: 75/368 - (20%)

  Fly    86 GNSMNMYYYGLIGIGTPEQYFKVVFDTGSANLWVPSAQCLATDVACQQHNQYNSSASSTFVSSGQ 150
            |:|...||..|: ||||.|...::.||||:|..|..|  |..|:.    ..::|..|:::.....
 Frog    69 GDSGRGYYLELL-IGTPPQKMNILVDTGSSNFAVAGA--LNPDIT----TFFDSKLSTSYEPLNT 126

  Fly   151 NFSIQYGTGSVSGYLAIDTVT----INGLAIANQTFGEAVSQPGASFTDVAFDGILGMGYQQIAE 211
            ..:::|..||.:|.|..|.::    :||..:.|  .............::.:.||||:.|..:|:
 Frog   127 QVTVRYTQGSWTGLLGKDVISMPKGVNGTFLIN--IASIFQSENFFLPNINWQGILGLAYSTLAK 189

  Fly   212 -DNVVPPFYN--LYEEGLIDEPVFGFYLARNGS-----AVDGGQLTLGGTDQNLIAGEMTYTPVT 268
             .:.|.||::  :.:|.:.:  :|...:...|.     .::.|.|.|||.:.:|..|::.|||:|
 Frog   190 PSSSVEPFFDSLVQQENIPN--IFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQGDIWYTPIT 252

  Fly   269 QQGYWQFAV-------NNITWNGTVISSGCQAIADTGTSLIAAPSAAYIQLNNLIGGVPIQGDYY 326
            ::.|:|..|       .|:..:.||.:|. :||.|:||:|:..|...:   |.::       |..
 Frog   253 EEWYYQVEVLKFEVGGQNLNLDCTVYNSD-KAIVDSGTTLLRLPDKVF---NAMV-------DAI 306

  Fly   327 VPCSTVSS-----------------------LPVLTINIGGTN------FYLPPSVYIQ---TYT 359
            |..|.:.:                       .|.::|.:..||      ..|.|.:|||   |:.
 Frog   307 VQTSLIQNFNAEFWAGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQSVLTFQ 371

  Fly   360 EGNYTTCMSTFTDIGTGFWILGDVFLGQYYSEFDFGQNRVGFA 402
            |.  ..|............::|...:..:|..||..:.|||||
 Frog   372 ES--LNCFRFGISQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33128	NP_787961.1	pepsin_retropepsin_like	83..403	CDD:472175	92/368 (25%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	90/365 (25%)