Protein Alignment LeuRS and leuS

DIOPT Version :10

• Sequence 1: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_415175.1
• Gene: leuS / 947497
• ECOCYCID: EG10532
• Length: 860
• Species: Escherichia coli
• Alignment Length: 1064
• Identity: 206/1064 - (19%)
• Similarity: 340/1064 - (31%)
• Gaps: 391/1064 - (36%)

  Fly    16 QKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSLSKAEYSMRYHR 80
            ::||.:||..|:.:|..|     ..:....||::.....||.:||||:||..:.:..:...||.|
E. coli     8 EEIESKVQLHWDEKRTFE-----VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQR 67

  Fly    81 LKGRRVLWPFGFHCTGMPIKACADK---------------LTRELEQFGF-----------PPQF 119
            :.|:.||.|.|:...|:|.:..|.|               :..:|:..||           .|::
E. coli    68 MLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEY 132

  Fly   120 PETEE----------VVPVAAEAASEVPKDKSKGKKSKAV--------AKTGAAKY-QWQIMQSL 165
            ...|:          :|.....|.:..|.|::.....:.:        .|....:. || .::..
E. coli   133 YRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCDTKVERKEIPQW-FIKIT 196

  Fly   166 GLKDEEIKDFANAEHWLNYFPPLAVQDLKR--IGVHVDWRRTFITTDANPYFDSFVRWQFNHLKE 228
            ...||.:.|....:||     |..|:.::|  ||.......||...|
E. coli   197 AYADELLNDLDKLDHW-----PDTVKTMQRNWIGRSEGVEITFNVND------------------ 238

  Fly   229 RGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVGPQEYTLIKMKVLEVPKALSSIKQPIFMVAATL 293
                 |....|:|                                                  |.
E. coli   239 -----YDNTLTVY--------------------------------------------------TT 248

  Fly   294 RPETMYGQTNCWL---HPDIKYIAWQANKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQ 355
            ||:|..|.|...:   ||    :|.:|.:||....:.....||.     ...|.|:..: |..|.
E. coli   249 RPDTFMGCTYLAVAAGHP----LAQKAAENNPELAAFIDECRNT-----KVAEAEMATM-EKKGV 303

  Fly   356 DLLGVPLSAPLTKHKVVYSLPMLS---IKEDKGTGVVTSVPSDSPDDYAALVDLQKKEAFRQKYG 417
            | .|.....|||..::    |:.:   :..:.|||.|.:||.....||          .|..|||
E. coli   304 D-TGFKAVHPLTGEEI----PVWAANFVLMEYGTGAVMAVPGHDQRDY----------EFASKYG 353

  Fly   418 LKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQSQNDKDKLAEAKEM------CYLKSFYDGV 476
            |..:        |:|       |:|..:...|..|:..:|..|..:.|.      ....:..|.:
E. coli   354 LNIK--------PVI-------LAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKL 403

  Fly   477 MLVGAFAGRKIQDVKKD---LQKRLVDANEADVYYEPEKTIMSRSADECVVALCNQWYLN----- 533
            ..:|. ..||:....:|   .::|...|....|..| :.|:|....|:..|.|.....::
E. coli   404 TAMGV-GERKVNYRLRDWGVSRQRYWGAPIPMVTLE-DGTVMPTPDDQLPVILPEDVVMDGITSP 466

  Fly   534 -YGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKLPWDDKWLIESLSDS 597
             ..:|||   |...::||....|                  :.|:              ::..:|
E. coli   467 IKADPEW---AKTTVNGMPALRE------------------TDTF--------------DTFMES 496

  Fly   598 TIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAIKQEHLAVLRRE 662
            :.|.|.||...                               :||..|..:.|
E. coli   497 SWYYARYTCPQ-------------------------------YKEGMLDSEAA------------ 518

  Fly   663 FEYWYPMDLRVSGKDLIQNHLTFCLYNHAA-----------------------------IWPNDE 698
             .||.|:|:.:.|.:....||.:..:.|..                             :..|.|
E. coli   519 -NYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGE 582

  Fly   699 NKW-----------PKGMRVN-----GHLLL--NSAKMSKSDGNFLTLTEAVDKFSADGMRLCLA 745
            ..|           .||..|.     ||.|:  ..:|||||..|.:.....|:::.||.:||.:.
E. coli   583 RNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMM 647

  Fly   746 DAG----------DSVEDAN---------FVESTADAGILRLYTFIEWVKEMLENRSSLRKGTDK 791
            .|.          ..||.||         ..|.||...:..|.     |..:.||:.:||:...|
E. coli   648 FASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAALN-----VDALTENQKALRRDVHK 707

  Fly   792 TFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYEL--QLAR---DKYRELCGANGMHEDLVL 851
            |.            .:.||:..|:..|..|: :...||  :||:   |..::    ..:.::.:|
E. coli   708 TI------------AKVTDDIGRRQTFNTAI-AAIMELMNKLAKAPTDGEQD----RALMQEALL 755

  Fly   852 EFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWP---EVGAINEVDILCSEYLMEAAHSFRL 913
            ..:|    :::|..||:...:|..|..:..|.:|.||   |...:.:..::
E. coli   756 AVVR----MLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLV-------------- 802

  Fly   914 NLKNLLQIKGKAGKDKSVNVQAAK 937
                ::|:.||.....:|.|.|.:
E. coli   803 ----VVQVNGKVRAKITVPVDATE 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	206/1064 (19%)
leuS	NP_415175.1	LeuS	1..860	CDD:440261	206/1064 (19%)