Protein Alignment LeuRS and CDC60

DIOPT Version :10

• Sequence 1: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_015165.1
• Gene: CDC60 / 855943
• SGDID: S000006081
• Length: 1090
• Species: Saccharomyces cerevisiae
• Alignment Length: 1109
• Identity: 478/1109 - (43%)
• Similarity: 667/1109 - (60%)
• Gaps: 76/1109 - (6%)

  Fly     7 KGTFKVEYLQKIEREVQQRWEAERVHESDAPT---APKKRQAEKFFVTFP-------FPYMNGRL 61
            :.|.:.:.|..||::.|:.|..|...|.|||:   .|....:|:...|:|       :|||||.:
Yeast     8 ENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFMSSMAYPYMNGVM 72

  Fly    62 HLGHTFSLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFG-----FPPQFPE 121
            |.||.|:|||.|:|:.:.|:.|:|.|:|.|||||||||.||||||.||.|.||     .|.:..|
Yeast    73 HAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPAEEEE 137

  Fly   122 TEEVVPVAAEAASEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFP 186
            .:|..|  ||...| ...|.|.|||||.||.|..|||::||..||:..|||..||:|::||.|||
Yeast   138 IKEETP--AEKDHE-DVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFP 199

  Fly   187 PLAVQDLKRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMD 251
            ||...|...:|..:||||:|:|||||||:|:|:|||.|.||..|||.:|:||||||.||||.|||
Yeast   200 PLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMD 264

  Fly   252 HDRSSGEGVGPQEYTLIKMKVLEVPKALSSI---------KQPIFMVAATLRPETMYGQTNCWLH 307
            |||.|||||.||||..:|::.||.....:.|         .:..:.||||||||||||||.|::.
Yeast   265 HDRQSGEGVTPQEYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVS 329

  Fly   308 PDIKYIAWQANKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVV 372
            |.|:|..:.|  .:..:::|.||.:||:||..|...|..|.:..|.|:..:|..:.||.:.:..:
Yeast   330 PTIEYGIFDA--GDSYFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPEL 392

  Fly   373 YSLPMLSIKEDKGTGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTL 437
            ..|||.::...|||||||.|||:|||||....||..|..:   ||:|.|.: .:|.:||:.....
Yeast   393 RILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEY---YGIKPEWI-DHEIVPIMHTEKY 453

  Fly   438 GKLSAVHAYETLKIQSQNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDAN 502
            |.|:|....|..||||..||:.|||||::.|.:.:|.|.|:.|.:.|.|::..|..::..::.|.
Yeast   454 GDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAG 518

  Fly   503 EADVYYEPEKTIMSRSADECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNW 567
            ||.||.|||..:||||.|:|:|:|.:|||::|||..|:.||.:.|.||:.|..|.:|.||..|:|
Yeast   519 EAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDW 583

  Fly   568 LHEYACSRTYGLGTKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFR---GEKPGPFGIKPSD 629
            |..:|..|||||||:||||:|:|:|||||||||.:|||:.|||    |:   |.:.||.||....
Yeast   584 LKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLL----FKDYYGNEIGPLGISADQ 644

  Fly   630 MTGEIWDYIFFKETPLPKKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIW 694
            ||.|::||||..:..: |.|.|....|..|||||||:||:|:.:||||||.|||||.:|.|.|::
Yeast   645 MTDEVFDYIFQHQDDV-KNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALF 708

  Fly   695 PNDENKWPKGMRVNGHLLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVES 759
            |  :..||||:|.||||:||::|||||.|||:||.:.|:||.||..|:..|||||:||||||.||
Yeast   709 P--KKFWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDES 771

  Fly   760 TADAGILRLYTFIEWVKEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRS 824
            .|:|.||||:...||.:| :...|:||.|....|.|..|..|:|...::|.|.|....:|.||:.
Yeast   772 NANAAILRLFNLKEWAEE-ITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKY 835

  Fly   825 GFYELQLARDKYRELCGANGMHEDLVLEFIRRQALLVSPICPHMAEHVW-GLLGNKESIVHARWP 888
            |.::.|.|||.|||..|.  ||:||:..:|..||||::||.||.||::: .:|||:.|:.:|::|
Yeast   836 GLFDFQAARDYYREASGV--MHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFP 898

  Fly   889 EVGAINEVDILCS-EYLMEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPW 952
            ......:..:|.: :||.....|.|......|:.|    |.||..:.|:||.:..:.:::::|.|
Yeast   899 RASKPVDKGVLAALDYLRNLQRSIREGEGQALKKK----KGKSAEIDASKPVKLTLLISESFPEW 959

  Fly   953 QCCVLDTMKELFNKSQALPDNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTL 1017
            |...::.:::||:: |.|.|||.:...::.|.     |||.|||..::::::.:.|........|
Yeast   960 QSQCVEIVRKLFSE-QTLDDNKKVREHIEPKE-----MKRAMPFISLLKQRLANEKPEDVFEREL 1018

  Fly  1018 EFDERQVLISNLEYLKNTLD-LDVLEIKYTDDPSAPEK-----TREEVR------------PGSP 1064
            :|.|...:.:....:|.... |.:.|......|...:.     |.|||.            ||:|
Yeast  1019 QFSEIDTVKAAARNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVPGNP 1083

  Fly  1065 FISF 1068
            .:.|
Yeast  1084 GVVF 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	477/1107 (43%)
CDC60	NP_015165.1	leuS_arch	17..1088	CDD:273056	476/1100 (43%)