Protein Alignment LeuRS and NAM2

DIOPT Version :9

• Sequence 1: NP_001285589.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_013486.3
• Gene: NAM2 / 851098
• SGDID: S000004374
• Length: 894
• Species: Saccharomyces cerevisiae
• Alignment Length: 1123
• Identity: 200/1123 - (17%)
• Similarity: 351/1123 - (31%)
• Gaps: 411/1123 - (36%)

  Fly    22 VQQRWEAERVH---ESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSLSKAEYSMRYHRLKG 83
            :.::|:.:...   :.|...:..|      ::...|||.:|.||:||......::...|:::.||
Yeast    26 IGEKWKQKTTRGLPKQDTLNSGSK------YILCQFPYPSGALHIGHLRVYVISDSLNRFYKQKG 84

  Fly    84 RRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVPVAAEAASEVPKDKSKGKKSKA 148
            ..|:.|.|:                  :.||.|.:....|..:..|......:.|.|
Yeast    85 YNVIHPMGW------------------DAFGLPAENAAIERSINPAIWTRDNIAKMK-------- 123

  Fly   149 VAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGVHVDWRRTFITTDANP 213
                       |.|||:         .||                      .||.|...|.|  |
Yeast   124 -----------QQMQSM---------LAN----------------------FDWDREITTCD--P 144

  Fly   214 YFDSFVRWQFNHLKERGKIMYGKRYTI-YSPKDGQPCMDHDRSSGEGVGPQEYTLIKMKVLE--- 274
            .:..|.:|.|..|.|.| :.|.|...| :.|.| ...:.:::...:|...:...:::.|.|:
Yeast   145 EYYKFTQWIFLKLFENG-LAYRKEAEINWDPVD-MTVLANEQVDAQGRSWRSGAIVEKKQLKQWF 207

  Fly   275 ------VPKAL----------SSIKQ--------------------PIF--MVAATLRPETMYG- 300
                  .||..          |::||                    |.|  ::..|.||||::.
Yeast   208 LGITKFAPKLKKHLNQLKDWPSNVKQMQKNWIGESVGAELVFKVADPKFENLIVFTTRPETLFAV 272

  Fly   301 ------------QTNCWLHPDIKYIAWQANKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVT 353
                        |..|...||:|....::::           ..|.|.:||
Yeast   273 QYVALALDHPIVQKYCEEMPDLKEFIQKSDQ-----------LPNDTKEGF-------------- 312

  Fly   354 GQDLLGVPLSAPLTKHKV-VYSLPMLSIKEDKGTGVVTSVPSDSPDDY----------------A 401
              .|..:....||||.:| :::.|.:..........|...|.....|:                |
Yeast   313 --QLPNIKAVNPLTKEEVPIFAAPYVVSSYGSAPSAVMGCPGHDNRDFEFWQTNCPGEHIKTCIA 375

  Fly   402 ALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLK-IQSQNDKDKLAEA-- 463
            ...|...|...:::..:.|  .:|:.....:.....|:.|.|......| |....:.:.|:::
Yeast   376 PFFDDASKVTEQERQRIID--TVPFTSTDGVLTKECGEHSGVLTVVARKSIMGMLNSEGLSKSVV 438

  Fly   464 ----KEMCYLKSFYDG--VMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMSRSADEC 522
                ::....:..|.|  :.::.......:...:.||..:|.:....|....|..||     ||.
Yeast   439 RYKIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVKLPELEGLDTKGNPLSTI-----DEF 498

  Fly   523 VVALC-------------------NQWYL-------NYGEPEWQAQATK------ILHGMETFHE 555
            |...|                   :.||.       |..:|..:..|:|      .:.|:|
Yeast   499 VNVACPSCGSPAKRETDTMDTFIDSSWYYFRFLDPKNTSKPFDREIASKNMPVDIYIGGVE---- 559

  Fly   556 EARNNFEACLNWLHEYACSRTYGLGTKLPWDDKWLIESLSDSTIYMAFYTVV--HLLQGGTFRGE 618
                  .|.|:.|:....::.  ||:...|.|        .:.|:..|..:|  .::||.|:...
Yeast   560 ------HAILHLLYSRFIAKF--LGSINAWSD--------PAGIFEPFKKLVTQGMVQGKTYVDP 608

  Fly   619 KPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHL 683
            ..|.| :||.::|       |..::|                             .|..:|
Yeast   609 DSGKF-LKPDELT-------FVNDSP-----------------------------DGNTVI---- 632

  Fly   684 TFCLYNHAAIWPNDENKWPKGMRVNGHL-LLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADA 747
                                 ::.||.: :::..|||||..|.....|.:.:...|..|..:...
Yeast   633 ---------------------IKSNGKVPVVSYEKMSKSKYNGADPNECILRHGPDATRAHILFQ 676

  Fly   748 GDSVEDANFVESTADAGILRLYTFIEWVKEML---ENRSSLRKG----------TD------KTF 793
            ....:..|:.||.. .||.|      |::::|   :|..||.|.          ||      |..
Yeast   677 SPIADALNWDESKI-VGIER------WLQKVLHLTKNILSLEKDLAISKDYKTPTDLNDAEVKFH 734

  Fly   794 ND-QVFLS------ELNLKTQQTDENYRKM--LFKEALRSGFYELQLARDKYRELCGANGMHEDL 849
            || |.||.      |:||.......:|.|:  :.:.||:.|                  .:..::
Yeast   735 NDFQRFLKSITESFEVNLSLNTVISDYMKLTNILESALKKG------------------EVRNEM 781

  Fly   850 VLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYLMEAAHSFRLN 914
            :::.:::...::.|..|.::|....::.::......|||||....|......:.::.....|...
Yeast   782 IVQNLQKLVTVIYPAVPSISEEAAEMINSQMEWNQYRWPEVERTTESKFKKFQIVVNGRVKFMYT 846

  Fly   915 L-KNLLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQALPDNKVIAA 978
            . ||.|    |.|:|                          .|::|:..       ||:.::...
Yeast   847 ADKNFL----KLGRD--------------------------AVIETLMN-------LPEGRMYLM 874

  Fly   979 TLQQKAELKKFMKRVMPF 996
            .       ||..|.||.|
Yeast   875 N-------KKIKKFVMKF 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	200/1123 (18%)
		nt_trans	47..>204	CDD:294020	29/156 (19%)
		LeuRS_core	<525..758	CDD:173906	43/267 (16%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	30/147 (20%)
NAM2	NP_013486.3	leuS_bact	21..893	CDD:273057	200/1123 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900