Protein Alignment LeuRS and lars1

DIOPT Version :10

• Sequence 1: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001015831.1
• Gene: lars1 / 548548
• XenbaseID: XB-GENE-972511
• Length: 1177
• Species: Xenopus tropicalis
• Alignment Length: 1188
• Identity: 711/1188 - (59%)
• Similarity: 898/1188 - (75%)
• Gaps: 21/1188 - (1%)

  Fly     4 TERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFS 68
            ||||||.||::|:|||:::|::|:|:::.|.:|.....:....|:.||||:||||||||||||||
 Frog     2 TERKGTAKVDFLKKIEKDIQEKWDAQKLFEVNASDLQAQNSKGKYLVTFPYPYMNGRLHLGHTFS 66

  Fly    69 LSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFP-ETEEVVPVAAEA 132
            |||.|:::.|.|:||:..|:|||.||||||||||||||.||.|.||:||||| |.||....:|:.
 Frog    67 LSKCEFAVGYQRMKGKICLFPFGLHCTGMPIKACADKLKRETELFGYPPQFPEEEEEEEETSAKK 131

  Fly   133 ASEV-PKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRI 196
            ..|| .|||:|||||||.||:|::||||.||:||||.||||..|:.|||||:|||||||:|||.:
 Frog   132 EDEVIIKDKAKGKKSKAAAKSGSSKYQWGIMKSLGLSDEEIIRFSEAEHWLDYFPPLAVEDLKSM 196

  Fly   197 GVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVG 261
            |:.|||||:|||||.||::||||:|||..||||.:|.:|||||||||:||||||||||.:|||||
 Frog   197 GLKVDWRRSFITTDVNPFYDSFVKWQFLTLKERNRIKFGKRYTIYSPRDGQPCMDHDRQTGEGVG 261

  Fly   262 PQEYTLIKMKVLE-VPKALSSIK-QPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKNNEVW 324
            ||||||||||||| :|..||.:| :.:|:||||||||||:|||||||.||:.|||:: ..|.:::
 Frog   262 PQEYTLIKMKVLEPIPTKLSGLKGRNVFLVAATLRPETMFGQTNCWLRPDMPYIAFE-TANGDIF 325

  Fly   325 VSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGTGVV 389
            :.|:||||||:|||||...|.:.|:.|:.|:||||..||||||.:||:|:||||:||||||||||
 Frog   326 ICTQRAARNMSYQGFTKDNGVVPVVKELMGEDLLGAALSAPLTSYKVIYALPMLTIKEDKGTGVV 390

  Fly   390 TSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQSQ 454
            ||||||:|||.|||.||:||:|.|||||:|||||||:||:|||::|..|.|||....:.||||||
 Frog   391 TSVPSDAPDDIAALRDLKKKQALRQKYGIKDEMVLPFEPVPIIDIPGYGNLSAPMVCDELKIQSQ 455

  Fly   455 NDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMSRSA 519
            ||::||.||||..|||.||:|||:|..:.|:|:|||||.:||.:::..||.:|.||||.:|||||
 Frog   456 NDREKLTEAKEKVYLKGFYEGVMIVPGYEGQKVQDVKKPIQKLMIEKGEAMIYMEPEKQVMSRSA 520

  Fly   520 DECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKLP 584
            ||||||||:||||:|||..|:.|.|:.|..:|||.||.|.||||.|.||.|:|||||||||::||
 Frog   521 DECVVALCDQWYLDYGEANWKTQTTECLKSLETFCEETRRNFEASLGWLQEHACSRTYGLGSRLP 585

  Fly   585 WDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKKT 649
            ||::||||||||||||||:|||.|||||....|:...|.||:|..||.|:|||||||:.|.| ||
 Frog   586 WDEQWLIESLSDSTIYMAYYTVCHLLQGKELSGQGASPLGIRPEQMTKEVWDYIFFKKAPFP-KT 649

  Fly   650 AIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLLLN 714
            .|::|.|..|::|||:|||:|||||||||:.|||::.||||.|:||.|..|||..:|.|||||||
 Frog   650 TIQKEKLEKLKQEFEFWYPVDLRVSGKDLVPNHLSYFLYNHVAMWPEDSGKWPVAVRANGHLLLN 714

  Fly   715 SAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWVKEML 779
            |.|||||.||||||:|||:|||||||||.||||||:||||||||:.||||||||||::|||||||
 Frog   715 SEKMSKSTGNFLTLSEAVEKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEML 779

  Fly   780 ENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELCGANG 844
            .|..|||.||..||||:||.||:|....:|::||.||:|||||::||:|.|.|:|||||| ...|
 Frog   780 ANFDSLRSGTSHTFNDRVFASEINAGIVKTEQNYEKMMFKEALKTGFFEFQAAKDKYREL-AIEG 843

  Fly   845 MHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYLMEAAH 909
            ||.|||.:||..|.||::|||||:.||:|.|||..:|::.|.||..|.::||.|..|:||.|.||
 Frog   844 MHRDLVFKFIETQTLLLAPICPHLCEHIWSLLGKTDSLMKASWPVTGPVDEVLIRSSQYLTETAH 908

  Fly   910 SFRLNLKNLLQIKGKAGKDKSVNVQ-AAKPNRGLVWVAKTYPPWQCCVLDTMKELF--NKSQALP 971
            ..||.|||.:    ...|.|.|:.| ..||:...::|||.|||||...|.|:::.:  |..| ||
 Frog   909 DLRLRLKNYM----APAKGKKVDKQPPQKPSHCTIYVAKNYPPWQHKTLLTLRKHYEANAGQ-LP 968

  Fly   972 DNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLKNTL 1036
            ||||||..|....||||:|||||||..||:|.:|. ||:..|.:.|||||:.||:.|:.||.|:|
 Frog   969 DNKVIATELNALPELKKYMKRVMPFVAMIKENLEK-KGLRVLDLELEFDEQTVLLENIVYLTNSL 1032

  Fly  1037 DLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNVSVELTNPIERSSLFQVNTVISEGDTVQ 1101
            :||.:|:|:..|  |.:|.:|:..||.||..|...|.|.|.|.||...:..|.....|.|||:.:
 Frog  1033 ELDQIEVKFASD--ADDKVKEDCCPGKPFSVFRTEPGVPVFLVNPQPANGHFSTKIAIREGDSRE 1095

  Fly  1102 SLREKLSKI-IGLKTDAATLKIWRYEDPVLGPRKIPNFEDYKAGKSVLG-EGNFVLDVENKKVSL 1164
            |:..:|.|. .|:| |...:|:.||:|||||||::|.....:.||||:. :..|.:|:..|||.:
 Frog  1096 SIIRRLMKTDRGIK-DVTKVKLMRYDDPVLGPRRVPVLGKEEVGKSVISPKAAFHIDLNEKKVHI 1159

  Fly  1165 EQAGKLTEVGRNLIYVVD 1182
            ...|..|::|..|:|||:
 Frog  1160 ADNGLKTDIGDTLVYVVE 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	666/1070 (62%)
lars1	NP_001015831.1	PLN02959	5..1063	CDD:215518	663/1068 (62%)