DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS and LARS1

DIOPT Version :9

Sequence 1:	NP_001285589.1	Gene:	LeuRS / 326262	FlyBaseID:	FBgn0284253	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_064502.9	Gene:	LARS1 / 51520	HGNCID:	6512	Length:	1176	Species:	Homo sapiens

Alignment Length:	1184	Identity:	700/1184 - (59%)
Similarity:	889/1184 - (75%)	Gaps:	18/1184 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSL 69
            |||||.||::|:|||:|:||:|:.|||.|.:|....|:....|:|||||:|||||||||||||||
Human     3 ERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSL 67

  Fly    70 SKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFP-ETEEVVPVAAEAA 133
            ||.|:::.|.||||:..|:|||.||||||||||||||.||:|.:|.||.|| |.||....:.:..
Human    68 SKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTE 132

  Fly   134 SEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGV 198
            ..:.|||:|||||||.||.|::||||.||:||||.||||..|:.|||||:||||||:|||||:|:
Human   133 DIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGL 197

  Fly   199 HVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVGPQ 263
            .|||||:|||||.|||:||||||||..|:||.||.:||||||||||||||||||||.:|||||||
Human   198 KVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQ 262

  Fly   264 EYTLIKMKVLE-VPKALSSIK-QPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKNNEVWVS 326
            ||||:|:|||| .|..||.:| :.||:||||||||||:||||||:.||:|||.:: ..|.::::.
Human   263 EYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFE-TVNGDIFIC 326

  Fly   327 TRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGTGVVTS 391
            |::|||||:|||||...|.:.|:.|:.|:::||..||||||.:||:|.||||:||||||||||||
Human   327 TQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTS 391

  Fly   392 VPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQSQND 456
            ||||||||.|||.||:||:|.|.|||::|:||||:||:|:||:|..|.||||...:.||||||||
Human   392 VPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQND 456

  Fly   457 KDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMSRSADE 521
            ::|||||||..|||.||:|:|||..|.|:|:|||||.:||:::||.:|.:|.||||.:||||:||
Human   457 REKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDE 521

  Fly   522 CVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKLPWD 586
            ||||||:||||:|||..|:.|.::.|..:|||.||.|.||||.|.||.|:||||||||||.||||
Human   522 CVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWD 586

  Fly   587 DKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAI 651
            ::||||||||||||||||||.||||||...|:...|.||:|..||.|:|||:||||.|.| ||.|
Human   587 EQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFP-KTQI 650

  Fly   652 KQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLLLNSA 716
            .:|.|..|::|||:|||:|||||||||:.|||::.||||.|:||...:|||..:|.||||||||.
Human   651 AKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSE 715

  Fly   717 KMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWVKEMLEN 781
            |||||.|||||||:|:||||||||||.||||||:||||||||:.||||||||||::||||||:.|
Human   716 KMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN 780

  Fly   782 RSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELCGANGMH 846
            ..|||.|...||||:||.||||....:||:||.||:|||||::||:|.|.|:|||||| ...|||
Human   781 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYREL-AVEGMH 844

  Fly   847 EDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYLMEAAHSF 911
            .:||..||..|.||::|.|||:.||:|.|||..:||::|.||..|.:|||.|..|:||||..|..
Human   845 RELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDL 909

  Fly   912 RLNLKN-LLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQA-LPDNK 974
            ||.||| ::..|||    |:......||:...::|||.|||||...|..:::.|..:.. |||||
Human   910 RLRLKNYMMPAKGK----KTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNK 970

  Fly   975 VIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLKNTLDLD 1039
            |||:.|....||||:||:||||..||:|.:|. .|...|.:.|||||:.||:.|:.||.|:|:|:
Human   971 VIASELGSMPELKKYMKKVMPFVAMIKENLEK-MGPRILDLQLEFDEKAVLMENIVYLTNSLELE 1034

  Fly  1040 VLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNVSVELTNPIERSSLFQVNTVISEGDTVQSLR 1104
            .:|:|:..:  |.:|.||:..||.|...|.:.|.|||.|.||...:..|.....|.:||...|:.
Human  1035 HIEVKFASE--AEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSII 1097

  Fly  1105 EKLSKI-IGLKTDAATLKIWRYEDPVLGPRKIPNF-EDYKAGKSVLGEGNFVLDVENKKVSLEQA 1167
            .:|.|: .|:| |.:.:|:.|::||:||||::|.. ::|.....:.....|.:|:.:||:.|.:.
Human  1098 RRLMKMNRGIK-DLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTEN 1161

  Fly  1168 GKLTEVGRNLIYVV 1181
            |...::|..:||:|
Human  1162 GIRVDIGDTIIYLV 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	662/1067 (62%)
		nt_trans	47..>204	CDD:294020	106/157 (68%)
		LeuRS_core	<525..758	CDD:173906	160/232 (69%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	73/119 (61%)
LARS1	NP_064502.9	tRNA-synt_1g	5..1062	CDD:330949	660/1066 (62%)
		'HIGH' region	53..63		9/9 (100%)
		Editing domain	260..509		156/249 (63%)
		'KMSKS' region	716..720		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148881
Domainoid	1	1.000	584	1.000	Domainoid score	I206
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7083
Inparanoid	1	1.050	1428	1.000	Inparanoid score	I117
Isobase	1	0.950	-	0	Normalized mean entropy	S618
OMA	1	1.010	-	-		QHG62150
OrthoDB	1	1.010	-	-		D131349at33208
OrthoFinder	1	1.000	-	-		FOG0004267
OrthoInspector	1	1.000	-	-		oto89886
orthoMCL	1	0.900	-	-		OOG6_101014
Panther	1	1.100	-	-	LDO	PTHR45794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1447
SonicParanoid	1	1.000	-	-		X3006
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750