Protein Alignment LeuRS and IleRS

DIOPT Version :9

• Sequence 1: NP_001285589.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_524840.2
• Gene: IleRS / 45785
• FlyBaseID: FBgn0027086
• Length: 1229
• Species: Drosophila melanogaster
• Alignment Length: 1407
• Identity: 270/1407 - (19%)
• Similarity: 467/1407 - (33%)
• Gaps: 483/1407 - (34%)

  Fly    19 EREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPF----PYMNGRLHLGHTFSLSKAEYSMRYH 79
            |..|.|:|..|.:.|       |..|..|....:.|    |:..|..|.||..:.:..:...||.
  Fly    23 EENVLQKWRHENIFE-------KCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYA 80

  Fly    80 RLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVPVAAEAASEVPKDKSKGK 144
            ..:|..|...||:.|.|:|::...|||..                         .:.|:|
  Fly    81 YQQGYHVDRRFGWDCHGLPVEFEIDKLLN-------------------------IKGPED----- 115

  Fly   145 KSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGVHVDWRRTFITT 209
                |||.|.|.|..:..:.:         ...|:.|.|.        :.|:|..:|::..:.|
  Fly   116 ----VAKMGIAAYNAECRKIV---------MRYADEWENV--------VTRVGRWIDFKNDYKT- 158

  Fly   210 DANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPC------MDHDRSSGEGVGPQEYTLI 268
             ..|::...:.|.|..|.::|.:..|.:...||    ..|      .:.:::..|.|.|  ..::
  Fly   159 -LYPWYMESIWWIFKQLFDKGLVYQGVKVMPYS----TACTTSLSNFEANQNYKEVVDP--CVVV 216

  Fly   269 KMKVLEVPKALSSIKQPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKNNEVWVSTRRAARN 333
            .::.:.:|..        |.:..|..|.|:.....|.:||.:.|:..:..|::.::|   .|...
  Fly   217 ALEAVSLPNT--------FFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFV---LAESR 270

  Fly   334 MTYQGFTAVEGEIK-VLAEVTGQDLLGVPLSAPLTKH----KVVYSLPMLSIKEDKGTGVVTSVP 393
            ::|...:..|.|:| .....|.:||...||.....|.    |....|....:.||.|||:|.:.|
  Fly   271 LSYVYKSETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAP 335

  Fly   394 SDSPDDY-----AALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQS 453
            ....|||     |.|:             .|...||    .|:.|.   |:.:
  Fly   336 YFGEDDYRVCLAAGLI-------------TKSSEVL----CPVDEA---GRFT------------ 368

  Fly   454 QNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDL------QKRLVDANEADVYYEPEK 512
                   .||.:                |.|:.::|..|.:      :..||.:.:....|
  Fly   369 -------NEASD----------------FEGQYVKDSDKQIMAALKARGNLVSSGQVKHSY---- 406

  Fly   513 TIMSRSADECVVALCNQWYLNYGEPEWQAQATKIL------HGMETFHEEARNNFEACLNWLHE- 570
            ....||....:......|::..     :..:..:|      :.:..|.:|.|..     |||.|
  Fly   407 PFCWRSDTPLIYKAVPSWFVRV-----EHMSKNLLDCSSQTYWVPDFVKEKRFG-----NWLKEA 461

  Fly   571 --YACSRTYGLGTKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGE 633
              :|.||....||.:|   .|...|..::.:..:...:..|             .|::..|:..|
  Fly   462 RDWAISRNRYWGTPIP---IWRSPSGDETVVIGSIKQLAEL-------------SGVQVEDLHRE 510

  Fly   634 IWDYI---------------------FFKETPLPKKTAIKQEHLAV-LRREFEYWYPMDLRVSGK 676
            ..|:|                     :|:...:|    ..|:|... ..::|...:|.|....|.
  Fly   511 SIDHIEIPSAVPGNPPLRRIAPVFDCWFESGSMP----FAQQHFPFENEKDFMNNFPADFIAEGI 571

  Fly   677 DLIQNHLTFCLYNHAAIWPNDENKWP-KGMRVNGHLL-LNSAKMSKSDGNFLTLTEAVDKFSADG 739
            |..:......|....|::    ||.| |.:..:|.:| .:..||||...|:....|.|.|:.||.
  Fly   572 DQTRGWFYTLLVISTALF----NKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADA 632

  Fly   740 MRLCLADAG-DSVEDANFVESTADAGILRLY--TFIEW---VKEMLENRSSLRKGTDKTFNDQ-V 797
            :||.|.::. ...|...|.|.    |:..:.  .|:.|   .:.:|:|.....| .|...|.| .
  Fly   633 LRLYLINSPVVRAESLRFKEE----GVRDIIKDVFLPWYNAYRFLLQNIVRYEK-EDLAGNGQYT 692

  Fly   798 FLSELNLKTQQTDENYRK--------MLFKEALRSGF------YEL------------QL----A 832
            :..|.:||      |..|        :.|||:|...|      |.|            ||    .
  Fly   693 YDRERHLK------NMDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTNWYV 751

  Fly   833 RDKYRELCGANGMHE-----DLVLEFIRRQALLVSPICPHMAEHVW---------GLLGNKESIV 883
            |...|.:.|..|..:     |.:.:.:.....:::|..|::.|:::         |.|.:.:|:.
  Fly   752 RLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHADSVH 816

  Fly   884 HARWP----------------------EVGAINE--------------VDILCSEYLMEAAHSFR 912
            :...|                      |:|.:..              :.|.....::||..:.:
  Fly   817 YQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQILEAIKTLQ 881

  Fly   913 ------LNLKNLL-----------------------QIKG---------KAGKDKSV-------- 931
                  ||::.|.                       ::||         ||.:|..:
  Fly   882 DFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQGY 946

  Fly   932 -------------------------NVQAAKPNRGLVWVAKTYPPWQCC-------VLDTMKELF 964
                                     |.:|...|..||.:..| |..:..       |::.:::|.
  Fly   947 FDILDQRIELDEVRIIYCTSEQVGGNFEAHSDNEVLVLLDMT-PNEELLEEGLAREVINRVQKLK 1010

  Fly   965 NKSQALP------------DNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTL 1017
            .|:|.:|            |||.....|:.:|:|.|.:..   :|.:|:..::|
  Fly  1011 KKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLAKVLSN---YASIIKTAIKS----------- 1061

  Fly  1018 EF--------DERQVLISNLEYLKNTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNV 1074
            ||        .:::::.|.|      :||..:.:|.|..     .|.|...|..|:::.|:|.::
  Fly  1062 EFAPYSSEQASKKRLIASEL------VDLKGVPLKLTIC-----STEELQLPNLPWLNISLAEDL 1115

  Fly  1075 SVELTNPIERSSLFQVNTVISEGDTVQSLREKLSKIIGL--------------KTDA-------- 1117
            .....|. .::|||..:.|..|..::.:||.:|..:.||              :|.|
  Fly  1116 VPRFGNS-SKASLFLQHNVSKEIISLPTLRSELEHLFGLYGVNFNIYVVDHQKRTTALKSIDENL 1179

  Fly  1118 --ATLKIWRYEDP-------VLGPRKIPNFEDYKAGKSVLGE 1150
              ..|.:.|.:|.       .|.|.....|.:..:|||:..|
  Fly  1180 SGKLLVLTRSQDAPKLSAGYELSPAPYSKFINQHSGKSIFTE 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	245/1292 (19%)
		nt_trans	47..>204	CDD:294020	33/160 (21%)
		LeuRS_core	<525..758	CDD:173906	55/266 (21%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	34/169 (20%)
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	241/1272 (19%)
		IleRS_core	47..>189	CDD:173909	39/194 (20%)
		IleRS_core	<373..650	CDD:173909	63/330 (19%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	38/207 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840