DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS and ValRS

DIOPT Version :9

Sequence 1:	NP_001285589.1	Gene:	LeuRS / 326262	FlyBaseID:	FBgn0284253	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster

Alignment Length:	1059	Identity:	202/1059 - (19%)
Similarity:	327/1059 - (30%)	Gaps:	389/1059 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSL 69
            |::|.|..||.:.               ..|||. |.    .||.:..|.|.:.|.|||||..:.
  Fly   108 EKEGFFTPEYGRA---------------SIDAPN-PN----GKFVMIIPPPNVTGSLHLGHALTN 152

  Fly    70 SKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVPVAAEAAS 134
            :..:...||||:|||..||..|....|:..:...:||
  Fly   153 AIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKL---------------------------- 189

  Fly   135 EVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGVH 199
             :.:|:...:..     .|..|:           .|.|.|:...:....|      :.||.:|..
  Fly   190 -LWRDEKLSRHD-----LGREKF-----------IERIWDWRREKGGRIY------EQLKSLGSS 231

  Fly   200 VDWRRTFITTD---ANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVG 261
            .||.|...|.|   .....::|||     |.|.|.|....|...:|      |.  .||:...:.
  Fly   232 YDWTRVAFTMDPKLCRAVTEAFVR-----LHEEGSIYRSSRLVNWS------CT--LRSAISDIE 283

  Fly   262 PQEYTLIKMKVLEVPKALSSIKQPIF-------------MVAATLRPETMYGQTNCWLHP-DIKY 312
            ..:..:.....|.:|.....::..:.             ::.||.|.|||.|.|...:|| |.:|
  Fly   284 VDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAVHPQDDRY 348

  Fly   313 IAWQANKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPM 377
                                                      :.|.|..:..|.:..:    ||:
  Fly   349 ------------------------------------------KHLHGKFVVHPFSTRR----LPI 367

  Fly   378 LS---IKEDKGTGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGK 439
            :.   :....|||.|...|:..|:||    ::.|:            ..||:
  Fly   368 VCDEFVDMAFGTGAVKITPAHDPNDY----EVGKR------------CNLPF------------- 403

  Fly   440 LSAVHAYETLKIQSQNDKDKLAEAKEMCYLKSFYDGVML--VGAFAGRKIQDVKKDLQKRLVDAN 502
                       |...||                 ||.::  .|.|.|.|..:.:|.:.::|...|
  Fly   404 -----------ITIFND-----------------DGYIIGDYGEFTGMKRFECRKKILEKLKALN 440

  Fly   503 EADVYYEPEKT-----IMSRSADECVVALCNQWYLNYGEPEWQAQATKILHG--METFHEEARNN 560
               :|.|....     |.|||.|.....:..|||::..  :..|.||:.:..  ::...|.....
  Fly   441 ---LYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCS--DMAASATEAVRSGELKIIPEHHTKT 500

  Fly   561 FEACLNWLHEYACSRTYGLGTKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRG-------- 617
            :...::.:.::..||....|.::|              .|...:|...|..|.:..|
  Fly   501 WYHWMDGIRDWCVSRQLWWGHRIP--------------AYHVSFTDPSLQTGSSAHGSVNDDEQY 551

  Fly   618 ------------EKPGPFGIKPSDMT----GEIWDYIF------FKETPLPKKTAIKQEHLAVLR 660
                        :....||:..|.:.    .::.|..|      |.....|.:|
  Fly   552 WIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQT----------- 605

  Fly   661 REFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLLL------------ 713
            ::.:.:||..|..:|.|:    |.|               |...|...|..||
  Fly   606 KDLQTFYPTSLLETGHDI----LFF---------------WVARMVFFGQKLLGKLPFKEVYLHP 651

  Fly   714 -----NSAKMSKSDGNFLTLTEAVDKFSADGMRLCL------------ADAGDSVE-DANFVEST 760
                 :..|||||.||.:...:.:...:.:|:...|            |.||...: .....|..
  Fly   652 MVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECG 716

  Fly   761 ADAGILRLYTFIEWVKEM---LENRSSLRKGTDKTFN-----------DQVFLSELNLKT--QQT 809
            :||....|..:|...:::   :......|...:|.:|           .:.|.:||:...  .|.
  Fly   717 SDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQM 781

  Fly   810 DENYRKMLFK--EALRSGF--YELQLARDKYRELCGANGMHE--DLVLEFIR------------- 855
            |......|..  ||..:||  |:...|    ...|.|..:::  |:.||.::
  Fly   782 DAWILSRLAAAIEACNTGFESYDFAAA----TSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTA 842

  Fly   856 -RQAL---------LVSPICPHMAEHVWGLLGNKE---SIVHARWPEVGAIN----EVDILCSEY 903
             |:.|         |:||..|.:.|.::..|....   ||..|.:|...:..    |.|:   |:
  Fly   843 ARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYPSNTSWRSTKIESDV---EF 904

  Fly   904 LMEAAHSFR-----LNLKN 917
            :.:||...|     .||.|
  Fly   905 VQKAARIIRSARSDYNLPN 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	202/1059 (19%)
		nt_trans	47..>204	CDD:294020	35/156 (22%)
		LeuRS_core	<525..758	CDD:173906	48/294 (16%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	32/164 (20%)
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	202/1059 (19%)
		ValRS_core	129..736	CDD:185677	152/822 (18%)
		tRNA-synt_1_2	307..436	CDD:290334	38/231 (16%)
		Anticodon_Ia_Val	736..873	CDD:153416	27/140 (19%)
		Val_tRNA-synt_C	978..1053	CDD:287436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930