DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS and MetRS

DIOPT Version :9

Sequence 1:	NP_001285589.1	Gene:	LeuRS / 326262	FlyBaseID:	FBgn0284253	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster

Alignment Length:	1203	Identity:	216/1203 - (17%)
Similarity:	382/1203 - (31%)	Gaps:	471/1203 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 AKYQWQIMQSLGLKDEEIKDF-----ANAEHWLNYFPPLAVQDLKRIG------VHVDWRRTFIT 208
            ||...|: |.:.|.|.:.||.     ...::.|..|.|.|:.....:|      ..::|..|.:.
  Fly    22 AKQPVQV-QLVNLNDAKYKDLLVLPTLELDNGLRLFSPAAIAKYLFVGKGQQRDEWLEWSATLLA 85

  Fly   209 ------------TDAN--PYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEG 259
                        .|||  |..::.|:...:.||                  ..|.:..|:.|...
  Fly    86 PALAHHMAVGHKADANALPVLNALVKKLDDKLK------------------ATPYLAGDKPSAAD 132

  Fly   260 VGPQEYTLIKMKVLEVPKALSSIKQPIFMVAATLRPE-TMYGQTNCWLHPDIKYIAWQANKNNEV 323
            :.                           :.:.|.|: |:.|..|.              .|...
  Fly   133 IA---------------------------IWSLLAPDGTLKGAQNV--------------DNLRD 156

  Fly   324 WVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPL-----------TKHKVVYSLPM 377
            |.                  |.:|.|.||  |::|.   ..||           .::..::.:|:
  Fly   157 WY------------------GRVKALPEV--QEVLA---EQPLKDLSFNALQQSNRYGGLHHVPL 198

  Fly   378 --LSIKE------DKGTGVVTSVPSD------SPDDYAALVDLQKKEAFRQKYGLKDEMV---LP 425
              ||:.:      |....|..:|.::      :...|.|..:::::.....|.|.::.::   ||
  Fly   199 KRLSLADASKLLVDTTPTVADTVTNEEISAAKAAFTYTAPKEIKEERTVLPKPGERNVLITSALP 263

  Fly   426 YEPIPIIEVPTLGK-----LSA-VHA-------YETLKI------QSQNDKDKLAE---AKEMC- 467
            |    :..||.||.     ||| ::|       |.||.|      .:..:...|||   .:|:|
  Fly   264 Y----VNNVPHLGNIIGCVLSADIYARYSRSAGYNTLLICGTDEYGTATENKALAENLTPREICD 324

  Fly   468 -YLK---SFYDGVMLVGAFAGRKIQDVKKDL-QKRLVDANEADVYYEPEKTIMSRSADECVVALC 527
             |.:   :.|....:...:.||.....:.|: |:...|..:|..       |::.|.::.:...|
  Fly   325 KYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGY-------IITESVEQLLCQKC 382

  Fly   528 NQWYLNYGEPEWQAQATKILHGM----ETFHEEAR-NNFEACLNWLHE--------YACSRTYGL 579
            :::.           |.:.:.|.    ...:|:|| :..:.|...::.        ..|:....|
  Fly   383 DRFL-----------ADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNSAPVL 436

  Fly   580 GTK------LP--------WDDK---------------WLIESLSDSTIYMAFYTVVHLLQGGTF 615
            .:.      ||        |.||               ||.|
  Fly   437 RSSDQLFIDLPKAEPQLKEWVDKSEGGWTHNAKVITRAWLKE----------------------- 478

  Fly   616 RGEKPGPFGIKPSDMTGEI-WD-------------YIFFKETPLPKKTAIKQEHLAVLRREFEYW 666
                    |:||..:|.:: |.             |::| :.|....:..|:     ..:|::.|
  Fly   479 --------GLKPRCITRDLKWGIPVPHEGFEKKVFYVWF-DAPFGYVSMTKR-----YTKEYQQW 529

  Fly   667 YPMDLRVSGKD------LIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLL----LN--SAKMS 719
            :.   ...|.|      :.::::.|    |:.:||:......||..:..|::    ||  ..|.|
  Fly   530 WQ---PAKGTDVELFQFMAKDNVPF----HSVVWPSVLLAINKGHTLVSHIMATEYLNYEDGKFS 587

  Fly   720 KSDGNFLTLTEAVDK-FSADGMRLCLADAGDSVEDANF----------VESTADAG--ILRLYTF 771
            ||.|..:...:|.:. ..||..|..||.|....:|::|          .|...:.|  :.|...|
  Fly   588 KSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSFSWNDLAARNNSELLNNLGNFVNRALVF 652

  Fly   772 IEWVKEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKY 836
            .|      :|.||...|...|.::.|.|:.:|.:.:    .|...:.|..||.|...| ||..::
  Fly   653 CE------KNFSSTVPGVITTQDELVLLALINRELR----GYINSMEKAKLRDGVRHL-LAISRH 706

  Fly   837 RELCGANGMHED----------------------LVLEFIRRQALLVSPICPHMAEHVWGLLGNK 879
                 .||..:.                      |.:......|.|:.|..|..|..::|.|..|
  Fly   707 -----GNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANLLFPYMPTTARTLFGQLNAK 766

  Fly   880 ESIVHARWPEVGAINEVDILCSEYLMEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAKPNRGLVW 944
            ::.::|..|.|           ..|:.|.|                        |..||
  Fly   767 QTPLNAEKPLV-----------TLLLPAGH------------------------QIGKP------ 790

  Fly   945 VAKTYPPWQCCVLDTMKELFNKSQALPD---NKVIAATLQQKAELKKFMKRVMPFAQMIREKVES 1006
             |..:...:...:|.:|..:..:||..|   :::.||.|:         |.|...|..:||...|
  Fly   791 -APLFAKLEQSFIDELKGKYGGAQATNDAAHSQISAADLE---------KAVQAQADKVRELKAS 845

  Fly  1007 GKGVAALAVTLEFDERQVLISNLEYLKNTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVA 1071
            .|..|..         |..::.|..||..|:            .|.:||.....|.:     :.|
  Fly   846 TKDKAIW---------QPEVTKLLDLKKQLE------------EAKKKTATAAAPAA-----TPA 884

  Fly  1072 PNVSVELTNPIERSSLFQVNTVISEGDTVQSLREKLSKIIGLKTDAATLKIWRYEDPVLGPRKIP 1136
            |:...:....:|::              :|...:|:.|:.|...|..   :|:
  Fly   885 PSNGSQSVQDLEKA--------------IQEQGDKVRKLKGSTKDKT---VWQ------------ 920

  Fly  1137 NFEDYKAGKSVLGEGNFVLDVENKKVSLEQAGK 1169
                        .|.|.:||::.:..::::|.|
  Fly   921 ------------PEVNILLDLKKQLEAVQKAAK 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	201/1100 (18%)
		nt_trans	47..>204	CDD:294020	14/59 (24%)
		LeuRS_core	<525..758	CDD:173906	53/311 (17%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	31/153 (20%)
MetRS	NP_611382.1	GstA	1..175	CDD:223698	39/235 (17%)
		GST_N_family	1..65	CDD:238319	12/43 (28%)
		GST_C_family	63..164	CDD:295467	22/177 (12%)
		PRK12268	254..812	CDD:237029	127/681 (19%)
		MetRS_core	255..625	CDD:173907	82/435 (19%)
		Anticodon_Ia_Met	634..763	CDD:153411	30/144 (21%)
		MetRS_RNA	828..868	CDD:238475	14/69 (20%)
		MetRS_RNA	895..938	CDD:238475	11/83 (13%)
		MetRS_RNA	966..1009	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930