Protein Alignment LeuRS and Lars1

DIOPT Version :9

• Sequence 1: NP_001285589.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001009637.1
• Gene: Lars1 / 291624
• RGDID: 1304962
• Length: 1178
• Species: Rattus norvegicus
• Alignment Length: 1190
• Identity: 701/1190 - (58%)
• Similarity: 896/1190 - (75%)
• Gaps: 28/1190 - (2%)

  Fly     5 ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAE--KFFVTFPFPYMNGRLHLGHTF 67
            |||||.||::|:|||:||||:||||:|.|..|.:..|::|:.  |:|||||:|||||||||||||
  Rat     3 ERKGTAKVDFLKKIEKEVQQKWEAEKVFEVSASSLEKQKQSSKGKYFVTFPYPYMNGRLHLGHTF 67

  Fly    68 SLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVPVAAEA 132
            ||||.|:::.|.||||:..|:|||.||||||||||||||.||:|.:|.||.|||.||    ..|.
  Rat    68 SLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEE----EEEE 128

  Fly   133 ASEVP-----KDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQD 192
            :|..|     |||:|||||||.||.|::||||.||:||||.||:|..|:.|||||:|||||||||
  Rat   129 SSAKPGDIVMKDKAKGKKSKAAAKAGSSKYQWNIMKSLGLSDEDIAKFSEAEHWLDYFPPLAVQD 193

  Fly   193 LKRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSG 257
            ||:||:.|||||:|||||.|||:||||||||..|:||.||.:||||||||||||||||||||.:|
  Rat   194 LKKIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTG 258

  Fly   258 EGVGPQEYTLIKMKVLE-VPKALSSIK-QPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKN 320
            ||||||||||:|:|||: .|..||.:| :.||:||||||||||:||||||:.||:|||.:: ..|
  Rat   259 EGVGPQEYTLVKLKVLDPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFE-TAN 322

  Fly   321 NEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKG 385
            .::::.|:||||||:|||||...|.:.|:.|:.|:::||..||||||.:||:|.||||:||||||
  Rat   323 GDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVIYVLPMLTIKEDKG 387

  Fly   386 TGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLK 450
            ||||||||||||||:|||.||:||:|.|.||.::|:||||:||:|::|:|.:|.|.||...:.||
  Rat   388 TGVVTSVPSDSPDDFAALRDLKKKQALRAKYAVRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELK 452

  Fly   451 IQSQNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIM 515
            ||||||::|||||||..||:.||||||||..|.|:|||.|||.:||.::||.:|.:|.||||.::
  Rat   453 IQSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVV 517

  Fly   516 SRSADECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLG 580
            ||||||||||||:||||:||:..|:.|..:.|..||||.||:|.||||.|:||.|:|||||||||
  Rat   518 SRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACSRTYGLG 582

  Fly   581 TKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPL 645
            |:||||::||||||||||||||||||.||||||..:|:...|.||:|..||.::|||:|||:.|.
  Rat   583 TRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLQGQAESPLGIRPQQMTRDVWDYVFFKDAPF 647

  Fly   646 PKKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGH 710
            | ||.|.:|.|..|::|||:|||:|||.||||||.|||::.:|||.|:||...:|||..:|.|||
  Rat   648 P-KTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPVSVRANGH 711

  Fly   711 LLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWV 775
            |||||.|||||.||||||::||||||||||||.||||||:||||||||:.||||||||||::|||
  Rat   712 LLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWV 776

  Fly   776 KEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELC 840
            ||||.|.||||.|...:|||:||.||:|....:||:||.||:|||||::||:|.|.|:||||||
  Rat   777 KEMLANCSSLRSGPANSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYREL- 840

  Fly   841 GANGMHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYLM 905
            ...|||.:||..||..|.:|::|.|||:.||:|.|||..:||:||.||..|.::|..|..|:|||
  Rat   841 ATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDESLIRSSQYLM 905

  Fly   906 EAAHSFRLNLKN-LLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQA 969
            |.||..||.||| :...|||    |:......:|:...::|||.||.||...|.|::..|..:..
  Rat   906 EVAHDLRLRLKNYMTPAKGK----KTDKQPVQRPSHCTIYVAKNYPVWQHITLTTLRSHFEANNG 966

  Fly   970 -LPDNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLK 1033
             ||||||||..|....||||:||:||||..||:|.:|. ||...|.:.|||||:.||:.|:.||.
  Rat   967 KLPDNKVIACELGSLPELKKYMKKVMPFVAMIKENMEK-KGPRVLDLELEFDEQAVLMENIVYLT 1030

  Fly  1034 NTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNVSVELTNPIERSSLFQVNTVISEGD 1098
            |:|:|:.:::|:..:  |.:|.|||..||.|...|...|.|.|.|.||...|..|.....|.:||
  Rat  1031 NSLELEHIDVKFASE--AEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKIDIRQGD 1093

  Fly  1099 TVQSLREKLSKI-IGLKTDAATLKIWRYEDPVLGPRKIPNFEDYKAGKSVLGEGN-FVLDVENKK 1161
            :.:|:..:|:|: .|:| |.:.:|:.|::||:||||::|.....:..|:::.|.. |.:|:.:||
  Rat  1094 SCESIIRRLTKMDRGIK-DLSKVKLMRFDDPLLGPRRVPVLGREQNEKTLISENAIFHVDLVSKK 1157

  Fly  1162 VSLEQAGKLTEVGRNLIYVV 1181
            |.|.:.|...::|..::|:|
  Rat  1158 VHLTENGLRADIGDTIVYLV 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	662/1073 (62%)
		nt_trans	47..>204	CDD:294020	109/161 (68%)
		LeuRS_core	<525..758	CDD:173906	157/232 (68%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	72/119 (61%)
Lars1	NP_001009637.1	PLN02959	5..1064	CDD:215518	660/1072 (62%)
		nt_trans	47..>231	CDD:294020	129/187 (69%)
		LeuRS_core	<527..759	CDD:173906	157/232 (68%)
		Anticodon_Ia_Leu_AEc	757..876	CDD:153413	72/119 (61%)
		Anticodon_Ia_like	<858..907	CDD:299868	24/48 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342763
Domainoid	1	1.000	580	1.000	Domainoid score	I205
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7083
Inparanoid	1	1.050	1414	1.000	Inparanoid score	I109
OMA	1	1.010	-	-		QHG62150
OrthoDB	1	1.010	-	-		D131349at33208
OrthoFinder	1	1.000	-	-		FOG0004267
OrthoInspector	1	1.000	-	-		oto97002
orthoMCL	1	0.900	-	-		OOG6_101014
Panther	1	1.100	-	-	LDO	PTHR45794
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3006
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770