DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS and lrs1

DIOPT Version :9

Sequence 1:	NP_001285589.1	Gene:	LeuRS / 326262	FlyBaseID:	FBgn0284253	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_594882.1	Gene:	lrs1 / 2542670	PomBaseID:	SPAC26F1.13c	Length:	1111	Species:	Schizosaccharomyces pombe

Alignment Length:	1143	Identity:	539/1143 - (47%)
Similarity:	724/1143 - (63%)	Gaps:	90/1143 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATTE--------------RKGTFKVEYLQKIEREVQQRWEAERVHESDAPTA-----PKKRQAE 46
            |||||              .:.|.|.:.|.::|::.||:|:.|:..|.|||..     ..:::..
pombe     1 MATTEPSVEQLETKTAKLKLENTTKRDTLIELEKKYQQKWQEEKAFEVDAPLEDVPIDELRKKYP 65

  Fly    47 KFFVTFPFPYMNGRLHLGHTFSLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELE 111
            |||...|:|||||.|||||.|:|||.|::..:.||.|:|||:|.|||||||||.|.||:|:||:|
pombe    66 KFFGNMPYPYMNGALHLGHAFTLSKVEFTTAFERLNGKRVLFPMGFHCTGMPICASADRLSREIE 130

  Fly   112 QFGFPPQF---PETEEVVPVAAE---AASEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDE 170
            .||  |.|   .|.||.|.|..:   |..:|  .|..||||||.|||.|.|||:|||:|||:...
pombe   131 MFG--PSFDVPEEKEEEVEVEVKTPNAREDV--TKHSGKKSKAAAKTAAVKYQFQIMESLGVPRT 191

  Fly   171 EIKDFANAEHWLNYFPPLAVQDLKRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYG 235
            ||..||:|::||:|||||..:|....|:.:||||:|||||.|||:|||||||.|||.:.|||.:|
pombe   192 EIHKFADAKYWLSYFPPLCQRDCTEFGLGIDWRRSFITTDVNPYYDSFVRWQVNHLHDSGKIKFG 256

  Fly   236 KRYTIYSPKDGQPCMDHDRSSGEGVGPQEYTLIKMKVLEVP----KALSSI---KQPIFMVAATL 293
            :|||:||.|||||||||||.|||||||||||.|||:|||.|    |||.||   .:.:.|:||||
pombe   257 ERYTVYSIKDGQPCMDHDRKSGEGVGPQEYTGIKMEVLEFPEAARKALQSIDLSNKKVCMIAATL 321

  Fly   294 RPETMYGQTNCWLHPDIKYIAWQANKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLL 358
            |||||||||||::.|:|.|..:::|..||:::.|||||.||.||..:...|.:..|..:.||||:
pombe   322 RPETMYGQTNCYVGPNITYGIYESNVPNELFICTRRAANNMAYQKLSKERGVVSELGTIKGQDLI 386

  Fly   359 GVPLSAPLTKHKVVYSLPMLSIKEDKGTGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMV 423
            |..::|||:.||.||.|||.::...||||||||||||||||:|.|.:|:||..|   |.|..|.
pombe   387 GALVNAPLSVHKQVYVLPMETVLATKGTGVVTSVPSDSPDDFATLTELRKKAEF---YHLNPEW- 447

  Fly   424 LPYEPIPIIEVPTLGKLSAVHAYETLKIQSQNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQ 488
            :.||.:|||..|:.|.:.|....:.|||||..|..:||:|||:.|.:.||.|.|::|.::|.|::
pombe   448 MKYEAVPIIRTPSYGDMCAEFLCKKLKIQSPKDVKQLAQAKELAYKECFYQGTMIIGKYSGEKVE 512

  Fly   489 DVKKDLQKRLVDANEADVYYEPEKTIMSRSADECVVALCNQWYLNYGEPEWQAQATKILHGMETF 553
            ..|..::|.|:|...|.||.|||..::|||.|:|:||||:||:|:|||..|:|...|.|..:.||
pombe   513 TAKPKVRKELIDQGLAFVYNEPEGQVISRSGDDCIVALCDQWFLDYGEASWKAVTEKALDRLNTF 577

  Fly   554 HEEARNNFEACLNWLHEYACSRTYGLGTKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGE 618
            ..|.||.|...|:||.::||:|:|||||:||||.::|:|||:|||||||:||:.|||....: |:
pombe   578 SPEVRNGFLKTLDWLSQWACARSYGLGTRLPWDPQFLVESLTDSTIYMAYYTICHLLHSDVY-GK 641

  Fly   619 KPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHL 683
            .||...|||..||.|:||:: |::.|.||.|:|..|.||.|.|||:|:||.|:|.|||||:.|||
pombe   642 VPGALNIKPEQMTPEVWDHV-FRQAPKPKNTSISDEALARLCREFQYFYPFDIRASGKDLVPNHL 705

  Fly   684 TFCLYNHAAIWPNDENKWPKGMRVNGHLLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAG 748
            |||||.|.||:  ||..||||:|.|||||:|..|||||.|||:||.||..||.||..||.|||||
pombe   706 TFCLYTHTAIF--DEKYWPKGIRANGHLLMNGEKMSKSTGNFMTLHEATKKFGADATRLALADAG 768

  Fly   749 DSVEDANFVESTADAGILRLYTFIEWVKEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENY 813
            |:|:||||.|:.|::.||||||...|.|||:||..:||.| ...|:|:||.:|:|...:.:.|.:
pombe   769 DTVDDANFEEALANSAILRLYTQEAWCKEMMENLDNLRTG-PYNFHDKVFENEINQLIESSREAF 832

  Fly   814 RKMLFKEALRSGFYELQLARDKYRELCGANGMHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGN 878
            ...|||.||:|.||:||.|||.|||:.....||.|||..:|..|.||::...||.:||:|.....
pombe   833 SATLFKAALKSCFYDLQNARDWYREVTADRKMHRDLVCRWIETQVLLLATFAPHWSEHIWLTTLK 897

  Fly   879 KESIVH--ARWPEVGAINEVDILCSEYLM------------EAAHSFRLNLKNLLQIKGKAGKDK 929
            |...:|  .|:|:|.  :.|:...|..|:            |||           |:| :..|.|
pombe   898 KPQSIHVSGRFPQVS--SPVNTALSNSLLYIRTLSRVIREAEAA-----------QLK-RQKKGK 948

  Fly   930 SVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQALPDNKVIAATLQQKAELKKFMKRVM 994
            .:....:||.|..|:||:.:|.||...:..:::.:|:|:...|:|.|.:::.     ||.|||.|
pombe   949 GMLFDPSKPKRLTVFVAEKFPEWQAQYVALLQKYYNESENKFDDKAIISSVD-----KKEMKRAM 1008

  Fly   995 PFAQMIREKV-ESGKGVAALAV---TLEFDERQVLISNLEYLKNTLDLDVLEIKYTDDPSAPEKT 1055
            ||.|..::.| ..|:.|:|.::   .|.|:|.:||.....||...:.:..|.|.....|:  :|:
pombe  1009 PFIQQFKQSVINRGEHVSANSIFSRELGFNELEVLREVKPYLVRNVGIQELRIVLLQKPA--DKS 1071

  Fly  1056 REE---VRPGSPF-ISFSVAPNVSVELTNPIERSSLFQ 1089
            ...   |..||.. .:..:|||.:  .|.|.:.:.||:
pombe  1072 SAAIGLVESGSDAGATVEIAPNFA--NTVPGQPTFLFE 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	532/1120 (48%)
		nt_trans	47..>204	CDD:294020	89/162 (55%)
		LeuRS_core	<525..758	CDD:173906	137/232 (59%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	55/119 (46%)
lrs1	NP_594882.1	PLN02959	21..1106	CDD:215518	532/1120 (48%)
		nt_trans	66..>225	CDD:294020	89/162 (55%)
		LeuRS_core	<549..778	CDD:173906	137/232 (59%)
		Anticodon_Ia_Leu_AEc	776..895	CDD:153413	55/119 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	457	1.000	Domainoid score	I66
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7083
Inparanoid	1	1.050	969	1.000	Inparanoid score	I42
OMA	1	1.010	-	-		QHG62150
OrthoFinder	1	1.000	-	-		FOG0004267
OrthoInspector	1	1.000	-	-		oto101206
orthoMCL	1	0.900	-	-		OOG6_101014
Panther	1	1.100	-	-	LDO	PTHR45794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1447
SonicParanoid	1	1.000	-	-		X3006
TreeFam	1	0.960	-	-
	14	13.860