DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS and lars-1

DIOPT Version :9

Sequence 1:	NP_001285589.1	Gene:	LeuRS / 326262	FlyBaseID:	FBgn0284253	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_497837.1	Gene:	lars-1 / 175538	WormBaseID:	WBGene00003073	Length:	1186	Species:	Caenorhabditis elegans

Alignment Length:	1195	Identity:	648/1195 - (54%)
Similarity:	835/1195 - (69%)	Gaps:	42/1195 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSL 69
            |||   ||..||:||:.:|:.||:::..|:||....|    .|:.|||||||||||||||||||.
Worm     7 ERK---KVAQLQEIEKSIQELWESKKAFEADARDDGK----PKYLVTFPFPYMNGRLHLGHTFSA 64

  Fly    70 SKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPE-TEEVVPVAAEAA 133
            ||.|::..:.||:|:.||:||||||||||||||||||.||::.||:||.||| ..|.|.....|.
Worm    65 SKCEFAAGFQRLQGKEVLFPFGFHCTGMPIKACADKLKREMQDFGYPPNFPEDVVEEVKEEVSAV 129

  Fly   134 SEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGV 198
            .|:.||||||||||.|||||.||||||||:||||.|||||:|::..|||.||||..:.|||::|:
Worm   130 DEIIKDKSKGKKSKLVAKTGNAKYQWQIMKSLGLCDEEIKEFSDPNHWLYYFPPHCIADLKKMGL 194

  Fly   199 HVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVGPQ 263
            ..||||:|||||.|||||||||||||.|:...||.:||||||||||||||||||||:||||||||
Worm   195 KADWRRSFITTDVNPYFDSFVRWQFNLLRAAKKIDFGKRYTIYSPKDGQPCMDHDRASGEGVGPQ 259

  Fly   264 EYTLIKMKVLE-VPKALSSIKQPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKN-NEVWVS 326
            ||||||:|||: .|:|||.||:.|::||||||||||||||||:|||||:|..:.|.:| .:|:|:
Worm   260 EYTLIKLKVLDPKPQALSHIKEDIYLVAATLRPETMYGQTNCYLHPDIQYSVFYATENEKQVFVA 324

  Fly   327 TRRAARNMTYQGFTAVEGEIKV---LAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGTGV 388
            |.|:||.|:|||.|...|::..   |.::.|..:||.||||||.|::.||:||||:||:||||||
Worm   325 TARSARIMSYQGLTKENGKVNYVLGLEKIAGSKILGAPLSAPLAKYERVYALPMLTIKDDKGTGV 389

  Fly   389 VTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQS 453
            |||||||||||:|||.||:||:..|:||||.||||||:||:|||::..||.|:||.....|||:|
Worm   390 VTSVPSDSPDDFAALSDLKKKKPLREKYGLTDEMVLPFEPVPIIKIEGLGDLAAVEMCSRLKIES 454

  Fly   454 QNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMSRS 518
            ||:||||.|||:..|||.|||||||||.:||:|..||||.:|..|.....|..|.||||.:||||
Worm   455 QNEKDKLEEAKKEVYLKGFYDGVMLVGKYAGKKTADVKKVIQDDLTAEGLATKYVEPEKKVMSRS 519

  Fly   519 ADECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKL 583
            .||||||||:||||||||.||:|.|.|:|..:.||::|.|...|..::|||||||||:|||||||
Worm   520 GDECVVALCDQWYLNYGEAEWKAAAKKVLEPLRTFNDETRRGLETTVDWLHEYACSRSYGLGTKL 584

  Fly   584 PWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKK 648
            |||.::|||||||||||.|:|||.||||.|.|.|...||.|||...||...|.|:|..|....|.
Worm   585 PWDTQYLIESLSDSTIYNAYYTVAHLLQQGAFDGSVVGPAGIKADQMTDASWSYVFLGEIYDSKT 649

  Fly   649 TAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLLL 713
            ..:::|.|..||:||.||||:|:|.||||||.||||:.|:|||||||.|.:|||||:|.||||||
Worm   650 MPVEEEKLKSLRKEFMYWYPIDMRASGKDLIGNHLTYLLFNHAAIWPTDTSKWPKGIRANGHLLL 714

  Fly   714 NSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWVKEM 778
            |:.|||||.|||:||.||::|||||||||.||||||.:||||||.:.|||.||||:|.|||:|||
Worm   715 NNEKMSKSTGNFMTLEEAIEKFSADGMRLSLADAGDGLEDANFVYAMADAAILRLFTMIEWIKEM 779

  Fly   779 LENRSS--LRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELCG 841
            :|.|.:  |||.. |.|.|:||.:|:|.....|::||....||:||::||:|.|..||.|||||.
Worm   780 IEQRDAGLLRKDA-KKFADRVFANEMNSLIAATEQNYEATNFKDALKTGFFEYQAIRDTYRELCA 843

  Fly   842 A--NGMHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYL 904
            .  ..|.|.||..||..|.|::||||||:||::|.|||....||:|.||.|..::|...:.:.::
Worm   844 GIDEPMSESLVFRFIETQMLILSPICPHIAEYIWQLLGKDGLIVNAPWPTVDPVDEKLAIGARFI 908

  Fly   905 MEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTM-KELFNKSQ 968
            .|:...||..||..:..|.||.|:     ....|...:::|||.|||||..:||.: |:....:.
Worm   909 TESLAEFRARLKTYMTPKKKALKE-----IPEVPTEAVIYVAKEYPPWQKTILDILEKQAKANNG 968

  Fly   969 ALPDNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLK 1033
            ||||||.|:..:.::..||||.|:.|||.|||:|:.|. |||:|||.:...|:..:|..|::::.
Worm   969 ALPDNKAISQLIGKEESLKKFAKKAMPFVQMIKERFEQ-KGVSALASSSPVDQTSILNENIDFIM 1032

  Fly  1034 NTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFS--------VAPNVSVELTNPIERSSLFQV 1090
            |.||||.:.|::||:........|...|..|.::|:        ||.||.:       .:::|.|
Worm  1033 NALDLDRVTIRHTDEEGIDANIVETTVPLVPMLNFTPNRPTIKLVARNVQI-------CNAMFDV 1090

  Fly  1091 NTVISEGDTVQSLREKLSKIIGLKTDAATLKIWRYEDPVLGPRKIPNFEDYKAGKSVLGEGN-FV 1154
            :..|..||:|..:..|:.:|.........:.:|||::.|.|.|::.::.:.......|.:.: |.
Worm  1091 DVPIVNGDSVSMVIRKMRRISKAIKPKFEVSLWRYKNAVWGDRQMISYRNPFEENIQLSDADIFN 1155

  Fly  1155 LDVENKKVSLEQAGKLTEVGRNLIY 1179
            .:.:| |:|:....:..::||.::|
Worm  1156 FEADN-KISVTSGSEKFDLGRTIVY 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	621/1073 (58%)
		nt_trans	47..>204	CDD:294020	105/157 (67%)
		LeuRS_core	<525..758	CDD:173906	151/232 (65%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	63/123 (51%)
lars-1	NP_497837.1	PLN02959	6..1074	CDD:215518	622/1080 (58%)
		nt_trans	42..>200	CDD:294020	105/157 (67%)
		LeuRS_core	<526..759	CDD:173906	151/232 (65%)
		Anticodon_Ia_Leu_AEc	757..880	CDD:153413	63/123 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160402
Domainoid	1	1.000	536	1.000	Domainoid score	I134
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7083
Inparanoid	1	1.050	1259	1.000	Inparanoid score	I80
Isobase	1	0.950	-	0	Normalized mean entropy	S618
OMA	1	1.010	-	-		QHG62150
OrthoDB	1	1.010	-	-		D131349at33208
OrthoFinder	1	1.000	-	-		FOG0004267
OrthoInspector	1	1.000	-	-		oto19972
orthoMCL	1	0.900	-	-		OOG6_101014
Panther	1	1.100	-	-	LDO	PTHR45794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1447
SonicParanoid	1	1.000	-	-		X3006
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790