Protein Alignment LeuRS and lars-1

DIOPT Version :10

• Sequence 1: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_497837.1
• Gene: lars-1 / 175538
• WormBaseID: WBGene00003073
• Length: 1186
• Species: Caenorhabditis elegans
• Alignment Length: 1195
• Identity: 648/1195 - (54%)
• Similarity: 835/1195 - (69%)
• Gaps: 42/1195 - (3%)

  Fly     5 ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSL 69
            |||   ||..||:||:.:|:.||:::..|:||....|    .|:.|||||||||||||||||||.
 Worm     7 ERK---KVAQLQEIEKSIQELWESKKAFEADARDDGK----PKYLVTFPFPYMNGRLHLGHTFSA 64

  Fly    70 SKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPE-TEEVVPVAAEAA 133
            ||.|::..:.||:|:.||:||||||||||||||||||.||::.||:||.||| ..|.|.....|.
 Worm    65 SKCEFAAGFQRLQGKEVLFPFGFHCTGMPIKACADKLKREMQDFGYPPNFPEDVVEEVKEEVSAV 129

  Fly   134 SEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGV 198
            .|:.||||||||||.|||||.||||||||:||||.|||||:|::..|||.||||..:.|||::|:
 Worm   130 DEIIKDKSKGKKSKLVAKTGNAKYQWQIMKSLGLCDEEIKEFSDPNHWLYYFPPHCIADLKKMGL 194

  Fly   199 HVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVGPQ 263
            ..||||:|||||.|||||||||||||.|:...||.:||||||||||||||||||||:||||||||
 Worm   195 KADWRRSFITTDVNPYFDSFVRWQFNLLRAAKKIDFGKRYTIYSPKDGQPCMDHDRASGEGVGPQ 259

  Fly   264 EYTLIKMKVLE-VPKALSSIKQPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKN-NEVWVS 326
            ||||||:|||: .|:|||.||:.|::||||||||||||||||:|||||:|..:.|.:| .:|:|:
 Worm   260 EYTLIKLKVLDPKPQALSHIKEDIYLVAATLRPETMYGQTNCYLHPDIQYSVFYATENEKQVFVA 324

  Fly   327 TRRAARNMTYQGFTAVEGEIKV---LAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGTGV 388
            |.|:||.|:|||.|...|::..   |.::.|..:||.||||||.|::.||:||||:||:||||||
 Worm   325 TARSARIMSYQGLTKENGKVNYVLGLEKIAGSKILGAPLSAPLAKYERVYALPMLTIKDDKGTGV 389

  Fly   389 VTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQS 453
            |||||||||||:|||.||:||:..|:||||.||||||:||:|||::..||.|:||.....|||:|
 Worm   390 VTSVPSDSPDDFAALSDLKKKKPLREKYGLTDEMVLPFEPVPIIKIEGLGDLAAVEMCSRLKIES 454

  Fly   454 QNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMSRS 518
            ||:||||.|||:..|||.|||||||||.:||:|..||||.:|..|.....|..|.||||.:||||
 Worm   455 QNEKDKLEEAKKEVYLKGFYDGVMLVGKYAGKKTADVKKVIQDDLTAEGLATKYVEPEKKVMSRS 519

  Fly   519 ADECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKL 583
            .||||||||:||||||||.||:|.|.|:|..:.||::|.|...|..::|||||||||:|||||||
 Worm   520 GDECVVALCDQWYLNYGEAEWKAAAKKVLEPLRTFNDETRRGLETTVDWLHEYACSRSYGLGTKL 584

  Fly   584 PWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKK 648
            |||.::|||||||||||.|:|||.||||.|.|.|...||.|||...||...|.|:|..|....|.
 Worm   585 PWDTQYLIESLSDSTIYNAYYTVAHLLQQGAFDGSVVGPAGIKADQMTDASWSYVFLGEIYDSKT 649

  Fly   649 TAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLLL 713
            ..:::|.|..||:||.||||:|:|.||||||.||||:.|:|||||||.|.:|||||:|.||||||
 Worm   650 MPVEEEKLKSLRKEFMYWYPIDMRASGKDLIGNHLTYLLFNHAAIWPTDTSKWPKGIRANGHLLL 714

  Fly   714 NSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWVKEM 778
            |:.|||||.|||:||.||::|||||||||.||||||.:||||||.:.|||.||||:|.|||:|||
 Worm   715 NNEKMSKSTGNFMTLEEAIEKFSADGMRLSLADAGDGLEDANFVYAMADAAILRLFTMIEWIKEM 779

  Fly   779 LENRSS--LRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELCG 841
            :|.|.:  |||.. |.|.|:||.:|:|.....|::||....||:||::||:|.|..||.|||||.
 Worm   780 IEQRDAGLLRKDA-KKFADRVFANEMNSLIAATEQNYEATNFKDALKTGFFEYQAIRDTYRELCA 843

  Fly   842 A--NGMHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYL 904
            .  ..|.|.||..||..|.|::||||||:||::|.|||....||:|.||.|..::|...:.:.::
 Worm   844 GIDEPMSESLVFRFIETQMLILSPICPHIAEYIWQLLGKDGLIVNAPWPTVDPVDEKLAIGARFI 908

  Fly   905 MEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTM-KELFNKSQ 968
            .|:...||..||..:..|.||.|:     ....|...:::|||.|||||..:||.: |:....:.
 Worm   909 TESLAEFRARLKTYMTPKKKALKE-----IPEVPTEAVIYVAKEYPPWQKTILDILEKQAKANNG 968

  Fly   969 ALPDNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLK 1033
            ||||||.|:..:.::..||||.|:.|||.|||:|:.|. |||:|||.:...|:..:|..|::::.
 Worm   969 ALPDNKAISQLIGKEESLKKFAKKAMPFVQMIKERFEQ-KGVSALASSSPVDQTSILNENIDFIM 1032

  Fly  1034 NTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFS--------VAPNVSVELTNPIERSSLFQV 1090
            |.||||.:.|::||:........|...|..|.::|:        ||.||.:       .:::|.|
 Worm  1033 NALDLDRVTIRHTDEEGIDANIVETTVPLVPMLNFTPNRPTIKLVARNVQI-------CNAMFDV 1090

  Fly  1091 NTVISEGDTVQSLREKLSKIIGLKTDAATLKIWRYEDPVLGPRKIPNFEDYKAGKSVLGEGN-FV 1154
            :..|..||:|..:..|:.:|.........:.:|||::.|.|.|::.::.:.......|.:.: |.
 Worm  1091 DVPIVNGDSVSMVIRKMRRISKAIKPKFEVSLWRYKNAVWGDRQMISYRNPFEENIQLSDADIFN 1155

  Fly  1155 LDVENKKVSLEQAGKLTEVGRNLIY 1179
            .:.:| |:|:....:..::||.::|
 Worm  1156 FEADN-KISVTSGSEKFDLGRTIVY 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	621/1073 (58%)
lars-1	NP_497837.1	PLN02959	6..1074	CDD:215518	622/1080 (58%)