Protein Alignment LeuRS and LeuRS

DIOPT Version :10

• Sequence 1: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_317169.3
• Gene: LeuRS / 1277687
• VectorBaseID: AGAMI1_001636
• Length: 1195
• Species: Anopheles gambiae
• Alignment Length: 1196
• Identity: 834/1196 - (69%)
• Similarity: 978/1196 - (81%)
• Gaps: 15/1196 - (1%)

  Fly     1 MATT---ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLH 62
            ||||   |||||||||||||||||:|:||:.::|::.|||..|:|...|||.||||:||||||||
Mosquito     1 MATTMANERKGTFKVEYLQKIEREIQERWQRDKVYDVDAPKEPRKADDEKFLVTFPYPYMNGRLH 65

  Fly    63 LGHTFSLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVP 127
            |||.|||||||:::|||||||::||:|.||||||||||||||||.||:|.:|.||.||..|.:..
Mosquito    66 LGHAFSLSKAEFAVRYHRLKGKKVLFPLGFHCTGMPIKACADKLKREIELYGCPPVFPREEALAV 130

  Fly   128 V-AAEAASEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQ 191
            | ..|....|||||||||||||.||.|.||:||||||||||.|:||..|||.:|||:||||||::
Mosquito   131 VEKPEDRDVVPKDKSKGKKSKATAKAGTAKFQWQIMQSLGLTDDEIAKFANTDHWLDYFPPLAIR 195

  Fly   192 DLKRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSS 256
            |||.:|.|:|||||||||||||::||||||||||||.|||||||||:||:|||||||||||||||
Mosquito   196 DLKELGAHIDWRRTFITTDANPFYDSFVRWQFNHLKARGKIMYGKRHTIFSPKDGQPCMDHDRSS 260

  Fly   257 GEGVGPQEYTLIKMKVL-EVPKALSSI--KQPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQAN 318
            |||||||||||:||||. ::|..|:|.  |:|:::|..||||||||||||||:||||||||::..
Mosquito   261 GEGVGPQEYTLVKMKVTGKMPSKLASAAGKRPVYLVCGTLRPETMYGQTNCWVHPDIKYIAFETA 325

  Fly   319 KNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKED 383
            | .||||.||||||||:||||||||||||.|||:.|||::|:.||||||.:||:|:|||||||||
Mosquito   326 K-QEVWVCTRRAARNMSYQGFTAVEGEIKELAELVGQDIMGLQLSAPLTSNKVIYALPMLSIKED 389

  Fly   384 KGTGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYET 448
            ||||:|||||||||||||||||||||:.||:|||:.|||||||:|||||:||.||.|.||:||:.
Mosquito   390 KGTGIVTSVPSDSPDDYAALVDLQKKQPFREKYGITDEMVLPYQPIPIIDVPGLGNLCAVYAYDK 454

  Fly   449 LKIQSQNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKT 513
            .|||||||::||.||||:.|||.|||||||||...|:|:|||||||::.|||.||||||||||||
Mosquito   455 FKIQSQNDREKLTEAKELVYLKGFYDGVMLVGEHKGKKVQDVKKDLKQYLVDRNEADVYYEPEKT 519

  Fly   514 IMSRSADECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYG 578
            |||||.|.|||||||||||||||..||.|.|:.|..||.||||...|||.||:||||||||||||
Mosquito   520 IMSRSGDVCVVALCNQWYLNYGEAVWQKQTTEHLRTMELFHEEVSRNFEHCLDWLHEYACSRTYG 584

  Fly   579 LGTKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKET 643
            ||||||||.:||||||||||||||||||.||||.|:||||||.|.||...|||.|:||||||.:.
Mosquito   585 LGTKLPWDQQWLIESLSDSTIYMAFYTVAHLLQAGSFRGEKPSPLGITAEDMTPEVWDYIFFADA 649

  Fly   644 PLPKKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVN 708
            ..|.|:.:|::....|:|||.:|||:||||||||||||||||.||||.||||.|.:|||||:|.|
Mosquito   650 KPPAKSRVKRDAWEQLKREFNFWYPVDLRVSGKDLIQNHLTFFLYNHVAIWPKDASKWPKGVRCN 714

  Fly   709 GHLLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIE 773
            ||||||||||||||||||||.|::.||||||.||||||||||:||||||.:.|||||||||||||
Mosquito   715 GHLLLNSAKMSKSDGNFLTLYESIAKFSADGTRLCLADAGDSIEDANFVVTNADAGILRLYTFIE 779

  Fly   774 WVKEMLENRSSLRKG-TDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYR 837
            ||||.|.::..|||| .|.:.|||||.||:||.|:||||:|||||||||||:||:|.|.||||||
Mosquito   780 WVKETLASKPLLRKGPQDASINDQVFSSEMNLLTKQTDEHYRKMLFKEALRTGFFEFQTARDKYR 844

  Fly   838 ELCGANGMHEDLVLEFIRRQALLVSPICPHMAEHVW-GLLGNKESIVHARWPEVGAINEVDILCS 901
            ||||:||||..||:|||:|||||::|||||:|||:| .|||||.||:||.||.||.|:|..|.||
Mosquito   845 ELCGSNGMHASLVMEFIQRQALLIAPICPHVAEHIWCDLLGNKTSILHAAWPAVGPIDEQKIKCS 909

  Fly   902 EYLMEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNK 966
            ||||||||||||.|||..|.|...||..|.....|||:.|.:|||||:||||.||||||:||:.:
Mosquito   910 EYLMEAAHSFRLALKNATQHKAGGGKGASNKALVAKPSDGTIWVAKTFPPWQSCVLDTMRELYER 974

  Fly   967 --SQALPDNKVIAATLQQKAELKKFMKRVMPFAQMIREKVES--GKGVAALAVTLEFDERQVLIS 1027
              ...|||||:||..|.:|..|||:||||||||||:||:||:  |.|..|:.|||:||||:||..
Mosquito   975 QGDGKLPDNKIIATELGKKELLKKYMKRVMPFAQMVRERVEAVGGPGKQAMDVTLDFDEREVLGL 1039

  Fly  1028 NLEYLKNTLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNVSVELTNPIERSSLFQVNT 1092
            |.|||:|||:||.|.::|||:|.||||.|||||||.|||.|:|.|.|:|.|.||:|||.||.|..
Mosquito  1040 NAEYLRNTLELDTLTVRYTDEPDAPEKMREEVRPGVPFIVFTVKPFVTVTLENPVERSGLFTVTM 1104

  Fly  1093 VISEGDTVQSLREKLSKIIGLKTDAATLKIWRYEDPVLGPRKIPNFEDYKAGKSVLGEGNFVLDV 1157
            .:|:|||.::|:|||:|.||.|.|.:.|:|.||||||:|||.:|.|:||::||..:.||.|.::.
Mosquito  1105 NLSDGDTSKTLKEKLAKQIGFKADLSALEIMRYEDPVMGPRSLPTFQDYRSGKVTIEEGEFKVEP 1169

  Fly  1158 ENKKVSLEQAG-KLTEVGRNLIYVVD 1182
            |.|:|.|.... |...:|.:.|||::
Mosquito  1170 EKKQVLLSNGSFKDLNIGTSFIYVIN 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	778/1079 (72%)
LeuRS	XP_317169.3	None