DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LeuRS and Lars

DIOPT Version :9

Sequence 1:	NP_001285589.1	Gene:	LeuRS / 326262	FlyBaseID:	FBgn0284253	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_598898.2	Gene:	Lars / 107045	MGIID:	1913808	Length:	1178	Species:	Mus musculus

Alignment Length:	1189	Identity:	701/1189 - (58%)
Similarity:	893/1189 - (75%)	Gaps:	28/1189 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAE--KFFVTFPFPYMNGRLHLGHTFS 68
            ||||.||::|::||:|.||:||||:|.|..|....|::|:.  |:|||||:||||||||||||||
Mouse     4 RKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRLEKQKQSSKGKYFVTFPYPYMNGRLHLGHTFS 68

  Fly    69 LSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVPVAAEAA 133
            |||.|:::.|.||||:..|:|||.||||||||||||||.||:|.:|.||.|||.||    ..|.:
Mouse    69 LSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEE----EEEES 129

  Fly   134 SEVP-----KDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDL 193
            |..|     :||:|||||||.||.|::||||.||:||||.|::|..|:.|||||:||||||||||
Mouse   130 SAKPGDIVVRDKAKGKKSKAAAKAGSSKYQWDIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDL 194

  Fly   194 KRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGE 258
            |.||:.|||||:|||||.|||:||||||||..|:||.||.:||||||||||||||||||||.:||
Mouse   195 KTIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGE 259

  Fly   259 GVGPQEYTLIKMKVLE-VPKALSSIK-QPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKNN 321
            |||||||||:|:|||| .|..||.:| :.||:||||||||||:||||||:.||:|||.:: ..|.
Mouse   260 GVGPQEYTLVKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFE-TANG 323

  Fly   322 EVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGT 386
            ::::.|:||||||:|||||...|.:.|:.|:.|:::||..||||||.:||||.||||:|||||||
Mouse   324 DIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGT 388

  Fly   387 GVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKI 451
            |||||||||||||.|||.||:||:|.|.|:|::|:||||:||:|::|:|.:|.|.||...:.|||
Mouse   389 GVVTSVPSDSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKI 453

  Fly   452 QSQNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMS 516
            |||||::|||||||..||:.||||||||..|.|:|||.|||.:||.::||.:|.:|.||||.:||
Mouse   454 QSQNDREKLAEAKEKLYLRGFYDGVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVMS 518

  Fly   517 RSADECVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGT 581
            |||||||||||:||||:||:..|:.|..:.|..||||.||:|.||||.|:||.|:||||||||||
Mouse   519 RSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACSRTYGLGT 583

  Fly   582 KLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLP 646
            :||||::||||||||||||||||||.||||||...|:...|.||:|..||.::|||:|||:.|.|
Mouse   584 RLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESPLGIRPQQMTKDVWDYVFFKDAPFP 648

  Fly   647 KKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHL 711
             ||.|.:|.|..|::|||:|||:|||.||||||.|||::.:|||.|:||...:|||..:|.||||
Mouse   649 -KTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPVSVRANGHL 712

  Fly   712 LLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWVK 776
            ||||.|||||.||||||::||||||||||||.||||||:||||||||:.||||||||||::||||
Mouse   713 LLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVK 777

  Fly   777 EMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELCG 841
            |||.:.||||.|...:|||:||.||:|....:||:||.||:|||||::||:|.|.|:|||||| .
Mouse   778 EMLASCSSLRSGPADSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYREL-A 841

  Fly   842 ANGMHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYLME 906
            ..|||.:||..||..|.:|::|.|||:.||:|.|||..:||:||.||..|.::|..|..|:||||
Mouse   842 TEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGPVDESLIRSSQYLME 906

  Fly   907 AAHSFRLNLKN-LLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQA- 969
            .||..||.||| ::..|||    |:....|.:|:...::|||.||.||...|.|::..|..:..
Mouse   907 VAHDLRLRLKNYMMPAKGK----KTDKQPAQRPSHCTIYVAKNYPVWQHITLTTLRSHFEANNGK 967

  Fly   970 LPDNKVIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLKN 1034
            ||||||||:.|....||||:||:||||..||:|.:|. ||...|.:.|||||:.||:.|:.||.|
Mouse   968 LPDNKVIASELGSLPELKKYMKKVMPFVAMIKENMEK-KGPRVLDLELEFDEQAVLMENIVYLTN 1031

  Fly  1035 TLDLDVLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNVSVELTNPIERSSLFQVNTVISEGDT 1099
            :|:|:.:|:|:..:  |.:|.|||..||.|...|...|.|.|.|.||...|..|.....|.:||:
Mouse  1032 SLELEHIEVKFASE--AEDKVREECCPGKPLNVFRTEPGVPVSLVNPQPSSGHFSTKIDIRQGDS 1094

  Fly  1100 VQSLREKLSKI-IGLKTDAATLKIWRYEDPVLGPRKIPNFEDYKAGKSVLGEGN-FVLDVENKKV 1162
            .:|:..:|.|. .|:| |.:.:|:.|::||:||||::|......:.|:::.|.. |.:|:.:|||
Mouse  1095 CESIIRRLMKTDRGIK-DLSKVKLMRFDDPLLGPRRVPVLGREHSEKTLISENAVFHVDLVSKKV 1158

  Fly  1163 SLEQAGKLTEVGRNLIYVV 1181
            .|.:.|..|::|..::|:|
Mouse  1159 HLTENGLRTDIGDTMVYLV 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	661/1072 (62%)
		nt_trans	47..>204	CDD:294020	107/161 (66%)
		LeuRS_core	<525..758	CDD:173906	157/232 (68%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	71/119 (60%)
Lars	NP_598898.2	PLN02959	3..1064	CDD:215518	661/1073 (62%)
		nt_trans	47..>231	CDD:294020	127/187 (68%)
		'HIGH' region	55..65		9/9 (100%)
		LeuRS_core	<527..759	CDD:173906	157/232 (68%)
		'KMSKS' region	718..722		3/3 (100%)
		Anticodon_Ia_Leu_AEc	757..876	CDD:153413	71/119 (60%)
		Anticodon_Ia_like	<858..907	CDD:299868	24/48 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838959
Domainoid	1	1.000	574	1.000	Domainoid score	I224
eggNOG	1	0.900	-	-		E1_COG0495
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7083
Inparanoid	1	1.050	1410	1.000	Inparanoid score	I120
Isobase	1	0.950	-	0	Normalized mean entropy	S618
OMA	1	1.010	-	-		QHG62150
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004267
OrthoInspector	1	1.000	-	-		oto93462
orthoMCL	1	0.900	-	-		OOG6_101014
Panther	1	1.100	-	-	LDO	PTHR45794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1447
SonicParanoid	1	1.000	-	-		X3006
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740