DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Db and SERPINH1

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	373	Identity:	91/373 - (24%)
Similarity:	160/373 - (42%)	Gaps:	54/373 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LVMDKAESNFIASPLCIEIGISMILMGAKGTTAEELRSVLDLPVDVTEMAKKYE---------RI 85
            :..|:|..|.:.||:.:...:.::.:|.|.|||.:.::||.     .|..:..|         |.
Human    58 MAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLS-----AEQLRDEEVHAGLGELLRS 117

  Fly    86 MSNFQKHNGLRFTNW-----LYVNETYEVRQDYNTLMKSTFMAEG-----KDPLSQRKASNSISF 140
            :||....|    ..|     ||...:.....|:....|..:..|.     :|   :|.|..||:.
Human   118 LSNSTARN----VTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRD---KRSALQSINE 175

  Fly   141 SIHRKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVFHGDHNKKVYVRMMS 205
            ...:.:...:..::.|  ::..:.|:|||.:::...|..:|..|....:.|....:..|.|.||.
Human   176 WAAQTTDGKLPEVTKD--VERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMH 238

  Fly   206 HVGRFRIADHSYG--QIIEMPFDNSDLSMIIGLPLHNTYLSSIEKI-----LRTLSESLVENNVH 263
            ..|.:...|....  ||:|||..:...|:||.:|.|...|..:||:     |:.....:.:..|.
Human   239 RTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVA 303

  Fly   264 VELPKFKIKYQTELVESLKKLGI-HLIFSNTSDLSGLLTNGTGAK---INHVVHKSFIEINERGA 324
            :.|||..::...:|.:.|..||: ..|..|.:|||.:    :|.|   :..|.|.:..|::
Human   304 ISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM----SGKKDLYLASVFHATAFELD---- 360

  Fly   325 STGEASDHAESIQKKTRASTSFKVNRPFVFLIRDKH--TVYFRGRVVR 370
            :.|...|.....:::.|:...|..:.||:||:||..  ::.|.||:||
Human   361 TDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVR 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	88/369 (24%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	91/373 (24%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920