DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and SERPING1

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_000053.2	Gene:	SERPING1 / 710	HGNCID:	1228	Length:	500	Species:	Homo sapiens

Alignment Length:	385	Identity:	93/385 - (24%)
Similarity:	169/385 - (43%)	Gaps:	63/385 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SVLG----KFKLNLLEL--VMDKAESNFIASPLCIEIGISMILMGAKGTTAEELRSVLDLPVDVT 76
            :|||    .|.|.|...  .|.|.|:|...||..|...::.:|:||...|...|.|:|..|.|.|
Human   140 AVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFT 204

  Fly    77 EMAKKYERIMSNFQKHNGLRFTNWLYVNETYEVRQDYNTLMKSTFMAEGKD--PLSQRKASNS-- 137
            .:             |..|:......|....::....:..::.||:...:.  ..|.|..||:
Human   205 CV-------------HQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSD 256

  Fly   138 ---------ISFSIHRKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVFHG 193
                     ::.:.:.|..:.:.::.:|..|      ||:|.:|.|..|||.|..|.|:::.||
Human   257 ANLELINTWVAKNTNNKISRLLDSLPSDTRL------VLLNAIYLSAKWKTTFDPKKTRMEPFH- 314

  Fly   194 DHNKKVYVRMMSHVGRFRIADHSYGQIIEMPFD----NSDLSMIIGLPLHNTY-LSSIEK----- 248
            ..|..:.|.||:. .::.:| |...|.::....    :.:||::|.:|.:..: |..:|:
Human   315 FKNSVIKVPMMNS-KKYPVA-HFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPS 377

  Fly   249 ILRTLSESLVENNVH---VELPKFKIKYQTELVESLKKLGIHLIFSNTSDLSGLLTNGTGAKINH 310
            :.:.:.|.|..:...   :.||:.|:....:::..::||.. ..||...:|.| ||.....:::.
Human   378 VFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEF-FDFSYDLNLCG-LTEDPDLQVSA 440

  Fly   311 VVHKSFIEINERGASTGEASDHAESIQKKTRASTSFKVNRPFVFLIRDKHTVY--FRGRV 368
            :.|::.:|:.|.|.....||  |.|:   .|....|:|.:||:|::.|:...:  |.|||
Human   441 MQHQTVLELTETGVEAAAAS--AISV---ARTLLVFEVQQPFLFVLWDQQHKFPVFMGRV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	88/375 (23%)
SERPING1	NP_000053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..118
		7 X 4 AA tandem repeats of [QE]-P-T-[TQ]	85..119
		C1_inh	145..495	CDD:239005	88/378 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010