DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Db and SERPINB13

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001294852.1	Gene:	SERPINB13 / 5275	HGNCID:	8944	Length:	400	Species:	Homo sapiens

Alignment Length:	392	Identity:	104/392 - (26%)
Similarity:	176/392 - (44%)	Gaps:	79/392 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ESNFIASPLCIEIGISMILMGAKGTTAEELRSVLD---------LPVDVTEMAK---------KY 82
            :.|...||:.|...|.|:|:|.:|.||.:|..|..         :..:..|:.:         ..
Human    24 DGNIFFSPVGILTAIGMVLLGTRGATASQLEEVFHSEKETKSSRIKAEEKEVVRIKAEGKEIENT 88

  Fly    83 ERIMSNFQK----------HNGLRFTNWLYVNETYEVRQDYNTLMKSTFMAEGKDPL-------S 130
            |.:...|||          ...|..||.|:..:||...|.|...::..:.| ..:|:       .
Human    89 EAVHQQFQKFLTEISKLTNDYELNITNRLFGEKTYLFLQKYLDYVEKYYHA-SLEPVDFVNAADE 152

  Fly   131 QRKASNSISFSIHRKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVFHGDH 195
            .||..||   .:..|:::.::.:..|.::..:...||||.||:.|.|...|.|::||.:.|..:.
Human   153 SRKKINS---WVESKTNEKIKDLFPDGSISSSTKLVLVNMVYFKGQWDREFKKENTKEEKFWMNK 214

  Fly   196 NKKVYVRMM--SHVGRFRIADHSYGQIIEMPFDNSDLSMIIGLPLHNTYLSSIEKILRTLS-ESL 257
            :....|:||  ||...|...:....:|:.:|:.|:||||.:.||   ..:..:|||:..:| |.|
Human   215 STSKSVQMMTQSHSFSFTFLEDLQAKILGIPYKNNDLSMFVLLP---NDIDGLEKIIDKISPEKL 276

  Fly   258 V---------ENNVHVELPKFKIKYQTELVESLKKLGIHLIFS-NTSDLSGLLTNGTGAKINHVV 312
            |         |..|::.||:|:::...:|...|..:|:...|| :.:|.|| :::|:|......:
Human   277 VEWTSPGHMEERKVNLHLPRFEVEDGYDLEAVLAAMGMGDAFSEHKADYSG-MSSGSGLYAQKFL 340

  Fly   313 HKSFIEINERG----ASTG------EASDHAESIQKKTRASTSFKVNRPFVFLIR--DKHTVYFR 365
            |.||:.:.|.|    |:||      .|..| |::.          .|.||:|.||  :.:::.|.
Human   341 HSSFVAVTEEGTEAAAATGIGFTVTSAPGH-ENVH----------CNHPFLFFIRHNESNSILFF 394

  Fly   366 GR 367
            ||
Human   395 GR 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	104/392 (27%)
SERPINB13	NP_001294852.1	SERPIN	4..400	CDD:294093	104/392 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930