DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and SERPINB9

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_004146.1	Gene:	SERPINB9 / 5272	HGNCID:	8955	Length:	376	Species:	Homo sapiens

Alignment Length:	372	Identity:	99/372 - (26%)
Similarity:	170/372 - (45%)	Gaps:	33/372 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GKFKLNLLE-LVMDKAESNFIASPLCIEIGISMILMGAKGTTAEELRSVLDLPVDVTEMAKKYER 84
            |.|.:.||: |..|....|...||:.|...::|:|:||||.||.::...|.|..: .::.:.::.
Human     9 GTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSLNTE-EDIHRAFQS 72

  Fly    85 IMSNFQKHNG---LRFTNWLYVNETYEVRQDYNTLMKSTFMAEGKDPLSQRKASNS---ISFSIH 143
            :::...|...   ||..|.|:..:|.:....:.......:.||.|:....|.|..|   |:..:.
Human    73 LLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELKELSFIRAAEESRKHINTWVS 137

  Fly   144 RKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVFHGDHNKKVYVRMM---- 204
            :|:...:..:....::......||||.:|:.|.|...|.:..|:...|..:..::..|:||
Human   138 KKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYTREMPFKINQEEQRPVQMMYQEA 202

  Fly   205 ----SHVGRFRIADHSYGQIIEMPFDNSDLSMIIGLPLHNTYLSSIEKILR-------TLSESLV 258
                :|||..|      .|::|:|:...:||:::.||.....||::||.|.       |..:.:.
Human   203 TFKLAHVGEVR------AQLLELPYARKELSLLVLLPDDGVELSTVEKSLTFEKLTAWTKPDCMK 261

  Fly   259 ENNVHVELPKFKIKYQTELVESLKKLGIHLIF-SNTSDLSGLLTNGTGAKINHVVHKSFIEINER 322
            ...|.|.|||||::...::...|:.|||...| ...:|||.:... ....::..|||||:|:||.
Human   262 STEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGKADLSAMSAE-RDLCLSKFVHKSFVEVNEE 325

  Fly   323 GASTGEASDHAESIQKKTRASTSFKVNRPFVFLIRDK--HTVYFRGR 367
            |.....||......:....:...|..:.||:|.||..  :::.|.||
Human   326 GTEAAAASSCFVVAECCMESGPRFCADHPFLFFIRHNRANSILFCGR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	98/371 (26%)
SERPINB9	NP_004146.1	SERPIN	4..376	CDD:320777	99/372 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930