DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and SERPINB8

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001353127.1	Gene:	SERPINB8 / 5271	HGNCID:	8952	Length:	374	Species:	Homo sapiens

Alignment Length:	372	Identity:	106/372 - (28%)
Similarity:	184/372 - (49%)	Gaps:	35/372 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GKFKLNLLELVMDKAES-NFIASPLCIEIGISMILMGAKGTTAEELRSVLDLPVDVTEMAKKYER 84
            |.|.::|.:::.::..| |...||:.|...::|:.|||||:||.::...|.|..| .::.:.::.
Human     9 GTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKD-GDIHRGFQS 72

  Fly    85 IMSNFQKHNG---LRFTNWLYVNETYEVRQDYNTLMKSTFMAE------GKDPLSQRKASNSISF 140
            ::|...:...   ||..|.|:..:|.:...|:....:..:.||      .:|....||..|.
Human    73 LLSEVNRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEELSFAEDTEECRKHIND--- 134

  Fly   141 SIHRKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVFHGDHNKKVYVRMMS 205
            .:..|:...:..:.:...:......||||.:|:.|.|..:|.:|.|:..:|..:..||. |:||.
Human   135 WVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGMLFKTNEEKKT-VQMMF 198

  Fly   206 HVGRFRI--ADHSYGQIIEMPFDNSDLSMIIGLPLHNTYLSSIEKILR-------TLSESLVENN 261
            ...:|::  ||..:.|::|:|:...:|||:|.||..||.|:.:||.|.       |.||.|.::.
Human   199 KEAKFKMGYADEVHTQVLELPYVEEELSMVILLPDDNTDLAVVEKALTYEKFKAWTNSEKLTKSK 263

  Fly   262 VHVELPKFKIKYQTELVESLKKLGIHLIFSNT-SDLSGLLTNGTGAKINHVVHKSFIEINERGAS 325
            |.|.||:.|::...:|...|::||:...|... :|.||:.|. ....::.|.||.|:|:||.|..
Human   264 VQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAKADFSGMSTE-KNVPLSKVAHKCFVEVNEEGTE 327

  Fly   326 TGEASDHAESIQKKTRAS---TSFKVNRPFVFLIRDKHT--VYFRGR 367
            ...|:    ::.:.:|.|   ..|..:.||:|.||...|  :.|.||
Human   328 AAAAT----AVVRNSRCSRMEPRFCADHPFLFFIRHHKTNCILFCGR 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	105/371 (28%)
SERPINB8	NP_001353127.1	SERPIN	4..374	CDD:320777	106/372 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930