Protein Alignment Spn28Db and SERPINE2

DIOPT Version :10

• Sequence 1: NP_001356884.1
• Gene: Spn28Db / 326261
• FlyBaseID: FBgn0053121
• Length: 377
• Species: Drosophila melanogaster
• Sequence 2: XP_005246698.1
• Gene: SERPINE2 / 5270
• HGNCID: 8951
• Length: 410
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 114/398 - (28%)
• Similarity: 188/398 - (47%)
• Gaps: 44/398 - (11%)

  Fly     9 YLVLLLIAT----SVLGKFK-LNLLEL------------VMDKAESNFIASPLCIEIGISMILMG 56
            :|.|.|:|:    |:...|. |:|.||            |..:...|.:.||..|...:.|:.:|
Human    16 HLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLG 80

  Fly    57 AKGTTAEELRSVLDLPVD-VTEMAKKYERIMSNFQKHNGLRFTNWLYVNETYEVRQDYNTLMKST 120
            |.|.|.::|..|:...|: |.::.||..:.:.:.:..:.:...|.::|....|:...:.|..|..
Human    81 ADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDV 145

  Fly   121 FMAEGK-----DPLSQRKASNSISFSIHRKSHKGM-RTISNDHNLQINESAVLVNTVYYSGAWKT 179
            |..|.:     ||.|   |.:||:..:..::...: ..:|.|....:....||||.||:.|.||:
Human   146 FQCEVRNVNFEDPAS---ACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKS 207

  Fly   180 RFSKKDTKLKVFHGDHNKKVYVRMMSHVGRFRIADHS-----YGQIIEMPFDNSDLSMIIGLPLH 239
            ||..::||.:.|.....|...|.|::.:..||....|     :...||:|:....:||:|.||..
Human   208 RFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 272

  Fly   240 -NTYLSSI-----EKILRTLSESLVENNVHVELPKFKIKYQTELVESLKKLGIHLIF-SNTSDLS 297
             :|.||:|     .|.:.:....:|...|.|.||||....||:|.|.||.|||..:| |:.::.:
Human   273 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 337

  Fly   298 GLLTNGTGAKINHVVHKSFIEINERGASTGEASDHAESIQKKTRASTSFKVNRPFVFLIRDKHT- 361
            .:.|......::|::.|:.||::|.|.   :||....:|.....:...|.|:|||:|.||...|
Human   338 KITTGSENLHVSHILQKAKIEVSEDGT---KASAATTAILIARSSPPWFIVDRPFLFFIRHNPTG 399

  Fly   362 -VYFRGRV 368
             |.|.|::
Human   400 AVLFMGQI 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	serpin	18..370	CDD:476815	110/385 (29%)
SERPINE2	XP_005246698.1	serpinE2_GDN	33..408	CDD:381039	109/381 (29%)