DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and SERPINB6

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	XP_011512974.1	Gene:	SERPINB6 / 5269	HGNCID:	8950	Length:	454	Species:	Homo sapiens

Alignment Length:	383	Identity:	102/383 - (26%)
Similarity:	184/383 - (48%)	Gaps:	30/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLIATSVL-------GKFKLNLLELVMDKAESNFIASPLCIEIGISMILMGAKGTTAEELRSVL 69
            ||.|.::::       |.|.||||:.:......|...||:.:...::|:.|||||.||.::..:|
Human    71 LLHIKSAIMDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQIL 135

  Fly    70 DLPVD--VTEMAKKYERIMSNFQKHNG---LRFTNWLYVNETYEVRQDYNTLMKSTFMAEGK--D 127
            .....  ..::.:.::.:::...|...   ||..|.|:..::.:....:....:..:.||.:  |
Human   136 SFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELD 200

  Fly   128 PLSQ-RKASNSISFSIHRKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVF 191
            .:|. .|:...|:..:..|:...:..:.:..::......||||.||:.|.|..:|.|::|:.::|
Human   201 FISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLF 265

  Fly   192 HGDHNKKVYVRMMSHVGRFR--IADHSYGQIIEMPFDNSDLSMIIGLPLHNTYLSSIEKILR--- 251
            ....|::..|:||.....|:  .....:.||:.:|:...:|:|||.||...|.|.::||.|.
Human   266 KVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEK 330

  Fly   252 ----TLSESLVENNVHVELPKFKIKYQTELVESLKKLGIHLIFS-NTSDLSGLLTNGTGAKINHV 311
                |..:.:.|..|.|.||:||::...::...|:.||:...|. ..:|.||:  :.|...::.|
Human   331 FVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGM--SQTDLSLSKV 393

  Fly   312 VHKSFIEINERGASTGEASDHAESIQKKTRASTSFKVNRPFVFLIRDKHT--VYFRGR 367
            |||||:|:||.|.... |:..|..:.:..|....|..:.||:|.|:...|  :.|.||
Human   394 VHKSFVEVNEEGTEAA-AATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGR 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	98/366 (27%)
SERPINB6	XP_011512974.1	PAI-2	82..454	CDD:239013	99/372 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830