DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and SERPINF1

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	365	Identity:	83/365 - (22%)
Similarity:	163/365 - (44%)	Gaps:	59/365 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SNFIASPLCIEIGISMILMGAKGTTAEELRSVL--DLPVDVTEMAKKYERIM-------SNFQKH 92
            :|.:.|||.:...:|.:.:||:..|...:...|  || :...::...|:.::       .|.:..
Human    76 TNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDL-ISSPDIHGTYKELLDTVTAPQKNLKSA 139

  Fly    93 NGLRFTNWLYVNETY--EVRQDYNTLMKSTFMAEGKDPLSQRKASNSISFSIHRKSHKGMRTISN 155
            :.:.|...|.:..::  .:.:.|.|..:   :..|...|..::.:|.:...:..|..:..:.|.:
Human   140 SRIVFEKKLRIKSSFVAPLEKSYGTRPR---VLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPD 201

  Fly   156 DHNLQINESAVLVNTVYYSGAWKTRFSKKDTKLKVFHGDHNKKVYVRMMSH---VGRFRIADHSY 217
            :      .|.:|:...::.|.|.|:|..:.|.|:.|:.|..:.|.|.|||.   |.|:.:.....
Human   202 E------ISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLS 260

  Fly   218 GQIIEMPFDNSDLSMIIGLPLHNTYLSSIEKILRTLSESLVENNVH------------VELPKFK 270
            .:|.::|...| :|:|..|||      .:.:.|..:.|||....:|            :.:||.|
Human   261 CKIAQLPLTGS-MSIIFFLPL------KVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLK 318

  Fly   271 IKYQTELVESLKKLGIHLIFSNTSDLSGLLTNGTGAKINHVVHKSFIEINERGAST----GEASD 331
            :.|:.|:.:||:::.:..:| ::.|.|.:  .|...|:..|.|::..|.||.||.|    |....
Human   319 LSYEGEVTKSLQEMKLQSLF-DSPDFSKI--TGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPA 380

  Fly   332 HAESIQKKTRASTSFKVNRPFVFLIRDKHT--VYFRGRVV 369
            |       ......:.:|:||:|::||..|  :.|.|:::
Human   381 H-------LTFPLDYHLNQPFIFVLRDTDTGALLFIGKIL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	83/362 (23%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	83/365 (23%)
		O-glycosylated at one site	371..383		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010