DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and SERPIND1

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	407	Identity:	105/407 - (25%)
Similarity:	187/407 - (45%)	Gaps:	73/407 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GNNKIKYLVLLLIATSVLGKFKLNLLELVMDKAES--NFIASPLCIEIGISMILMGAKGTTAEEL 65
            |.::|:.|.:|      ..||..||..::.|:..:  |...:|:.|...:.||.:|.||.|.|::
Human   119 GKSRIQRLNIL------NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177

  Fly    66 RSVLDLPVDVTEMAKKYE--------RIMSN--FQKHNG--LRFTNWLYVNETYEVRQDYNTLMK 118
            .|:|... |....:.|||        |.:::  |:::.|  ||..|.||:.:.:.:..|:.|.::
Human   178 HSILHFK-DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVR 241

  Fly   119 STFMAEGK-----DPLSQRKASNSISFSIHRKSHKGMRTISNDHNLQINESAVLVNTVYYSGAWK 178
            ..:.||.:     ||....|.:|.|     .|..||:...:.: |:......:::|.:|:.|:|.
Human   242 EYYFAEAQIADFSDPAFISKTNNHI-----MKLTKGLIKDALE-NIDPATQMMILNCIYFKGSWV 300

  Fly   179 TRFSKKDTKLKVFHGDHNKKVYVRMMSHVGRFRIADHSY--GQIIEMPFDNSDLSMIIGLPLHNT 241
            .:|..:.|....|..:..:.|.|.||...|.|..|:...  ..|:::.:... :||:|.:|...:
Human   301 NKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLIVVPHKMS 364

  Fly   242 YLSSIE-----KILRTLSESLVENNVHVELPKFKIKYQTELVESLKKLGIHLIFSNTSDLSGLLT 301
            .:.::|     :::....:|:......|.|||||::....||||||.:||.::|....:::|:
Human   365 GMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI-- 427

  Fly   302 NGTGAKINHVVHKSFIEINERGASTGEASDHAESIQKKTRAST-------------SFKVNRPFV 353
            :.....|:...|:..|.:||.|                |:|:|             .|.|:|||:
Human   428 SDQRIAIDLFKHQGTITVNEEG----------------TQATTVTTVGFMPLSTQVRFTVDRPFL 476

  Fly   354 FLIRDKHT--VYFRGRV 368
            |||.:..|  :.|.|||
Human   477 FLIYEHRTSCLLFMGRV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	99/386 (26%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	105/407 (26%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020