DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Db and Serpina3g

DIOPT Version :9

Sequence 1:	NP_001356884.1	Gene:	Spn28Db / 326261	FlyBaseID:	FBgn0053121	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_033277.2	Gene:	Serpina3g / 20715	MGIID:	105046	Length:	440	Species:	Mus musculus

Alignment Length:	417	Identity:	108/417 - (25%)
Similarity:	173/417 - (41%)	Gaps:	91/417 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLIATSVLGKFKLNLLELVMDKAESNFIASPLCIEIGISMILMGAKGTTAEELRSVLD-LPVDV 75
            |.|::::....|.| ..:||:...:.|.:.||..|...::::.:|||..|   |:.:|: |..::
Mouse    35 LTLVSSNTDFAFSL-YRKLVLKNPDENVVFSPFSICTALALLSLGAKSNT---LKEILEGLKFNL 95

  Fly    76 TEMAKKYERIMSNFQKHNGLRFT----------------NWLYVNETYEVRQDYNTLMKSTFMAE 124
            ||..:.        ..|.|.|:.                :.|::.:..::..::....::.:.||
Mouse    96 TETPEP--------DIHQGFRYLLDLLSQPGNQVQISTGSALFIEKHLQILAEFKEKARALYQAE 152

  Fly   125 G-----KDPLSQRKASNSISFSIHRKSHKGMRTISNDHNLQINES--AVLVNTVYYSGAWKTRFS 182
            .     :.||...|..|.. .|.|.:. |..:.||.     :.||  .||||.:|:.|.||..|.
Mouse   153 AFTADFQQPLKATKLINDY-VSNHTQG-KIKQLISG-----LKESMLMVLVNYIYFKGKWKNPFD 210

  Fly   183 KKDTKLKVFHGDHNKKVYVRMMS----HVGRFRIADHSYGQIIEMPFDNSDLSMIIGLP----LH 239
            ..||....|:.|..:.|.|.||.    ....||..:.|. .::|:.:..:..:|.| ||    :.
Mouse   211 PNDTFKSEFYLDEKRSVIVSMMKTGYLTTPYFRDEELSC-TVVELKYTGNASAMFI-LPDQGRMQ 273

  Fly   240 NTYLSSIEKILRTLSESLVENNVH-VELPKFKIKYQTELVESLKKLGIHLIFSNTSDLSGLLTNG 303
            ....|...:.||....||....:| :.||||.|.....|...|.:|||..:||..:|||.:
Mouse   274 QVEASLQPETLRKWKNSLKPRMIHELRLPKFSISTDYSLEHILPELGIREVFSTQADLSAI---- 334

  Fly   304 TGAK---INHVVHKSFIEINERG----ASTGEAS-------DHAESIQKKTRASTSFKVNRPFVF 354
            ||.|   ::.||||:.:::.|:|    |:||.|.       |..|..           .||||:.
Mouse   335 TGTKDLRVSQVVHKAVLDVAEKGTEAAAATGMAGVGCCAVFDFLEIF-----------FNRPFLM 388

  Fly   355 LIRD--KHTVYFRGRVV------RLPN 373
            :|.|  .|...|..:|.      ..||
Mouse   389 IISDTKAHIALFMAKVTNPERSENFPN 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Db	NP_001356884.1	SERPIN	22..368	CDD:238101	103/394 (26%)
Serpina3g	NP_033277.2	SERPIN	46..407	CDD:214513	104/396 (26%)
Serpina3g	NP_033277.2	RCL	357..382		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110