Protein Alignment eIF4EHP and EIF4E2

DIOPT Version :10

• Sequence 1: NP_001163710.1
• Gene: eIF4EHP / 326255
• FlyBaseID: FBgn0053100
• Length: 248
• Species: Drosophila melanogaster
• Sequence 2: NP_004837.1
• Gene: EIF4E2 / 9470
• HGNCID: 3293
• Length: 245
• Species: Homo sapiens
• Alignment Length: 133
• Identity: 62/133 - (46%)
• Similarity: 89/133 - (66%)
• Gaps: 2/133 - (1%)

  Fly    42 GPGENRLQHTYCLWFSRKETQR--AAADYSKSLHMVGRCASVQQWWSLYSHLIRPTALKPYRELL 104
            ||.|:.||:.|..|:||:...|  ::..|.:::..:|..|||:|:|..|||::||..|..:.:..
Human    50 GPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFH 114

  Fly   105 LFKQGIIPMWEDPANSKGGQWLIRLRKNKVDRAWENVCMAMLGEQFLVGDEICGVVLQTKYPNPS 169
            |||:||.|||||.||..||:|:|||||....|.|||:.:|||||||:||:||||.|:..::....
Human   115 LFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDI 179

  Fly   170 IQV 172
            |.:
Human   180 ISI 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4EHP	NP_001163710.1	IF4E	48..>172	CDD:460281	59/125 (47%)
EIF4E2	NP_004837.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		1/1 (100%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000269|PubMed:17368478	54..57		0/2 (0%)
		IF4E	55..214	CDD:460281	59/128 (46%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000269|PubMed:17368478	95..99		1/3 (33%)
		EIF4EBP1/2/3 binding. /evidence=ECO:0000269|PubMed:17368478	150..157		3/6 (50%)