Protein Alignment P5CDh2 and ALDH4A1

DIOPT Version :10

• Sequence 1: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 257/535 - (48%)
• Similarity: 351/535 - (65%)
• Gaps: 5/535 - (0%)

  Fly    50 VANEKLLQYDEGSKERTELETALLGVLNRVEHVPIVINGQEFQAKEDFQQVLPYDIQQPIAHYGH 114
            ||||.:|.:.:||.||..|:.||..:..|:|.:|.|:..:|....:...||.|::....:|.:.:
Human    32 VANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCY 96

  Fly   115 AHRVLIQMAIDKSVEAQVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQAEMD 179
            |.:.|:..||:.::.|:.:||...::||..|:.:||.:::|..|..|:|.||:|||||:.|||:|
Human    97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEID 161

  Fly   180 -VAELVDFMRINPVFLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPA 243
             .|||:||.|.|..:..||...:||....:.  ||...|||.||||||||||||.|..|||..||
Human   162 AAAELIDFFRFNAKYAVELEGQQPISVPPST--NSTVYRGLEGFVAAISPFNFTAIGGNLAGAPA 224

  Fly   244 LMGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTST 308
            ||||.|:|||||:|:|::|.|::.|||||:|..::.||||:...|...||....|.||||||:..
Human   225 LMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVP 289

  Fly   309 VLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSML 373
            ..|.||:.||||::.:..:|||.||.|||||||||.||:.|:.|:.|:|:||||.|||||:||.|
Human   290 TFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRL 354

  Fly   374 YVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAVINRRAYDRIYMWLRYIDQSPSCQILVG 438
            |||.|||. .|:..|||..:.:.|...|....:|.||||:.:::.||..||.:...|||..||.|
Human   355 YVPHSLWP-QIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418

  Fly   439 GSCDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVYVYPDHKLKETMEKV-AQINHGLTGSVF 502
            |.||...||:|:|.:|..||....|.:||:..|:|.||||||.|.|||::.| :..::||||:||
Human   419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVF 483

  Fly   503 AQDQNFIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLGTPHSLLRWTSPQVIK 567
            :||::.::||....|...||..:||||||.:|||||||....:||:||.|.||.:||||||||||
Human   484 SQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIK 548

  Fly   568 ESYKTHRNIFYPYMQ 582
            |::|...:..|.|||
Human   549 ETHKPLGDWSYAYMQ 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:448367	252/521 (48%)
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	252/523 (48%)