Protein Alignment P5CDh2 and ALDH5A1

DIOPT Version :9

• Sequence 1: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_733936.1
• Gene: ALDH5A1 / 7915
• HGNCID: 408
• Length: 548
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 110/478 - (23%)
• Similarity: 190/478 - (39%)
• Gaps: 108/478 - (22%)

  Fly   123 AIDKSVEAQVKWDKVRLSDRIDIWERAAMLIAGRYRYN-----------IIAATMLGQGKTLRQA 176
            |:..:.||..:|.:|...      ||:::|   |..||           ||.|.   .||.|::|
Human   101 AVRAAYEAFCRWREVSAK------ERSSLL---RKWYNLMIQNKDDLARIITAE---SGKPLKEA 153

  Fly   177 EMDVAELVDFMRINPVFLRELAN-------YEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTG- 233
            ..::.....|:.    :..|.|.       :.|.:|     |.::.|:...|..|.|:|:||..
Human   154 HGEILYSAFFLE----WFSEEARRVYGDIIHTPAKD-----RRALVLKQPIGVAAVITPWNFPSA 209

  Fly   234 -----IAANLAYTPALMGNSVIWKPSDSAILSNYFVFKAL-------------------REAGVP 274
                 :.|.||     .|.:|:.||::..      .|.||                   .:||:|
Human   210 MITRKVGAALA-----AGCTVVVKPAEDT------PFSALALAEVNQGFLLDLDPLLLASQAGIP 263

  Fly   275 DGVVNFVPAEETTFASV---VTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGG 336
            .||.|.:|........|   :...|.::.|:|||::|..|:|....|.::.      |:..|.||
Human   264 SGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVK------RVSMELGG 322

  Fly   337 KNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDA 401
            .....|..||..:.|||..:.:.|...||.| .||..:    |.|..|.:..::..|. .::::.
Human   323 LAPFIVFDSANVDQAVAGAMASKFRNTGQTC-VCSNQF----LVQRGIHDAFVKAFAE-AMKKNL 381

  Fly   402 TYCDSF-----CSAVINRRAYDRIYMWLRYIDQ--SPSCQILVGGSCDKRRGYYVDPTVVLVKDL 459
            ...:.|     ...:||.:|.:::.   :.::.  |....::.||...:....:.:||::.....
Human   382 RVGNGFEEGTTQGPLINEKAVEKVE---KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQ 443

  Fly   460 DNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGSVFAQDQNFIEEAYDAFRVNVGNLN 524
            |.:...||...|:..|..:...:....:...|.:  ||.|..::||...|...  |.::.||.:.
Human   444 DMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV--GLAGYFYSQDPAQIWRV--AEQLEVGMVG 504

  Fly   525 VNDKSTGLMVGQQ-PFGAGHMTG 546
            ||:   ||:...: |||....:|
Human   505 VNE---GLISSVECPFGGVKQSG 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	110/478 (23%)
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	110/478 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900