DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and aldh1a3

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001038210.1	Gene:	aldh1a3 / 751785	ZFINID:	ZDB-GENE-061128-2	Length:	513	Species:	Danio rerio

Alignment Length:	534	Identity:	131/534 - (24%)
Similarity:	223/534 - (41%)	Gaps:	99/534 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LNRVEHVPIVIN--------GQEFQAKEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEAQV 132
            :..::|..|.||        |::|........|...||::       |.:..:..|:..:..|..
Zfish    26 ITEIKHTKIFINNEWHTSSKGKQFPTINPATGVKICDIEE-------ADKADVDEAVKAAKAAGQ 83

  Fly   133 K---WDKV------RLSDRI-DIWERAAMLIA-------GRYRYNIIAATMLGQGKTLRQ----- 175
            :   |.::      ||.:|: |:.||...::|       |:...:.....:.|..||||.
Zfish    84 RGSVWRRMDASSRGRLLNRLADLLERERAVLATLESKDTGKPFLHAFFVDLDGSIKTLRYYAGWT 148

  Fly   176 -----AEMDVAE-LVDFMRINPVFLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGI 234
                 ..|.|.| .|.|.:           :|||                 |...||.|:||..:
Zfish   149 DKIHGKTMPVDENFVCFTK-----------HEPI-----------------GVCGAIIPWNFPLL 185

  Fly   235 AANLAYTPAL-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKL 298
            .......||| .||:|:.||::...|:...|...::|||.|.||||.||....|..:.:..|..:
Zfish   186 MLMWKIAPALACGNTVVLKPAEQTPLTALHVAALIKEAGFPPGVVNVVPGFGPTAGAAIAGHMNI 250

  Fly   299 AGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYA 363
            ..:.|||::.|.:::....|.:     |..|:..|.||||...|.:.::.:.||..|.:.||...
Zfish   251 DKLAFTGSTEVGQLVKAAAASS-----NLKRVTLELGGKNPCIVFADSDLQLAVEETQKGAFFNQ 310

  Fly   364 GQKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAVINRRAYDRIYMWLRYID 428
            ||.|::.|.:||.|.:::..:|  |....|..:|..|.....:.....|::..:::|   |..:|
Zfish   311 GQACTAASRVYVQEPVYEEFVR--LSVERAKNIVIGDPMEPRTSHGPQIDQHQFEKI---LALVD 370

  Fly   429 --QSPSCQILVGGSCDKRRGYYVDPTVVL-VKDLDNIICREELLAPILGVYVYPDHKLKETMEKV 490
              :....::..||...:.||.::.||:.. ||| ...|.:||:..|:..:..:...  ::.:::.
Zfish   371 SGKKEGAKLEFGGCAVEDRGLFIHPTIFSDVKD-HMRIAKEEIFGPVQCIMKFECQ--QDVIDRA 432

  Fly   491 AQINHGLTGSVFAQDQN---FIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLG 552
            .....|||.:||.:|..   .:..|.:|..|.|...|.       :..|.|||...|:|...:||
Zfish   433 NSSQFGLTAAVFTRDVQRAMSVSAALEAGTVWVNCYNA-------LHAQTPFGGYKMSGNGRELG 490

  Fly   553 TPHSLLRWTSPQVI 566
             .::|..:|..:.|
Zfish   491 -EYALAEYTEVKAI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	131/534 (25%)
aldh1a3	NP_001038210.1	ALDH_F1AB_F2_RALDH1	28..506	CDD:143459	131/532 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810