DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and aldh4a1

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_957452.1	Gene:	aldh4a1 / 394133	ZFINID:	ZDB-GENE-040426-1179	Length:	556	Species:	Danio rerio

Alignment Length:	534	Identity:	249/534 - (46%)
Similarity:	351/534 - (65%)	Gaps:	5/534 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VANEKLLQYDEGSKERTELETALLGVLNRVEHVPIVINGQEFQAKEDFQQVLPYDIQQPIAHYGH 114
            |.||.:|::.||||||.|||.||..:..:.|.:|.||..:|...|:...|:.|::....:|.:.:
Zfish    25 VKNEPVLEFKEGSKERAELEEALRNLKGKTEEIPCVIGNEEVWTKDIRFQLSPFNHSHQVAKFCY 89

  Fly   115 AHRVLIQMAIDKSVEAQVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQAEMD 179
            |.:.|:..||:.||.|:.:||...:|||..|:.:||.:|:|..|..::|.||:|||||:.|||:|
Zfish    90 ADKDLLNKAIEASVAARREWDLKPVSDRAQIFFKAADIISGPKRAEVLAKTMIGQGKTVVQAEID 154

  Fly   180 VA-ELVDFMRINPVFLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPA 243
            .| ||:||.|.|.....||.:.:|:.  .:...|:|..|||.|||||::|||||.|..|||.|||
Zfish   155 AAPELIDFFRFNAKHAIELEDQQPLD--SDGSTNTMLYRGLEGFVAAVAPFNFTAIGGNLAGTPA 217

  Fly   244 LMGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTST 308
            ||||.|:|||||:|:.::|.|:|.|||:|:|..::.||||:...|...||....||||||||:..
Zfish   218 LMGNVVLWKPSDTAMSASYAVYKILRESGLPPNIIQFVPADGPVFGDTVTSSEHLAGINFTGSVP 282

  Fly   309 VLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSML 373
            ..|.||:.||||::.|:|:||:.||.|||||||||.||:..:.|..|||:||||.|||||:||.:
Zfish   283 TFKRLWKQVAQNLDIYKNFPRVAGECGGKNFHFVHKSADVRSVVTGTIRSAFEYGGQKCSACSRM 347

  Fly   374 YVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAVINRRAYDRIYMWLRYIDQSPSCQILVG 438
            |||:|||. .||:.||::...:.|........:|.||||:.:::.||..||.:...||..:|:.|
Zfish   348 YVPDSLWP-QIRQGLLDVYKQIKVGDPVEDFSTFFSAVIDDKSFSRIKGWLEHARSSPHLKIIAG 411

  Fly   439 GSCDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQIN-HGLTGSVF 502
            |:||.::||:|:||::...|....|..||:..|:|.|||||::..|:.:..:...: :.|||::|
Zfish   412 GNCDDKKGYFVEPTIIETTDPQEKIMNEEIFGPVLTVYVYPENDYKKVLHLIDNTSPYALTGAIF 476

  Fly   503 AQDQNFIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLGTPHSLLRWTSPQVIK 567
            .||::.||||..|.|...||..:||||||.:|.|||||....:||:||.|.||.:||||||||:|
Zfish   477 PQDKSVIEEAGKALRNAAGNYYINDKSTGSIVAQQPFGGARASGTNDKPGGPHYVLRWTSPQVVK 541

  Fly   568 ESYKTHRNIFYPYM 581
            :::.......||||
Zfish   542 QTHVPLTEWKYPYM 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	245/521 (47%)
aldh4a1	NP_957452.1	ALDH_F4-17_P5CDH	25..546	CDD:143441	245/523 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D293592at33208
OrthoFinder	1	1.000	-	-		FOG0004722
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850