DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh2 and aldh2.1

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_956784.1	Gene:	aldh2.1 / 393462	ZFINID:	ZDB-GENE-040426-1262	Length:	516	Species:	Danio rerio

Alignment Length:	510	Identity:	131/510 - (25%)
Similarity:	212/510 - (41%)	Gaps:	84/510 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VEHVPIVINGQEFQA--KEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEAQVKWDKVRLSD 141
            |.:..|.||.:...|  |:.|..:.| ...:.|.|.....:.    .:||:|:|  ..|..:|..
Zfish    33 VHYNKIFINNEWHDAVSKKTFPTINP-ATAEVICHVAEGDKA----DVDKAVKA--ARDAFKLGS 90

  Fly   142 ---RIDIWERAAMLIAGRYRYNIIA------ATMLGQGKTLRQAE-MDVAELVDFMRINPVFLRE 196
               |:|..:|..:|       |.:|      |..|.:.:||...: ..::..||.    |:.::.
Zfish    91 PWRRMDASQRGLLL-------NRLADCIERDAAYLAELETLDNGKPYTLSFCVDL----PMVVKC 144

  Fly   197 LANYEPIRD--------IQNN--CRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPAL-MGNSVI 250
            |..|....|        |..|  |.......|:.|   .|.|:||..:...|...||| .||:|:
Zfish   145 LRYYAGWADKWEGKTIPIDGNYFCYTRHEPIGVCG---QIIPWNFPLLMQALKLGPALATGNTVV 206

  Fly   251 WKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTSTVLKVLWQ 315
            .|.::...|:..::...::|.|.|.||||.||....|..:.:..|..:..:.|||::.|..::
Zfish   207 MKVAEQTPLTALYIASLIKEVGFPAGVVNIVPGFGPTAGAAIASHMDVDKVAFTGSTDVGHLI-- 269

  Fly   316 LVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYVPESLW 380
               |..:...|...:..|.|||:.:.:.|.|..|.||.....|.|...||.|.:.:..:|.||::
Zfish   270 ---QQASSASNLKNVSLELGGKSPNIILSDANMEEAVEQAHSALFFNQGQCCCAGTRTFVQESIY 331

  Fly   381 QNHIREPLLEITASLVV-------RQDATYCDSFCSAVINRRAYDRIYMWLRYID--QSPSCQIL 436
            ...: |..:|...:.:|       .:.....|.           |:....|.||.  :....:::
Zfish   332 DEFV-ERSVERAKNRIVGDPFDLNTEQGPQVDE-----------DQFKKVLGYISSGKREGAKLM 384

  Fly   437 VGGSCDKRRGYYVDPTVV-LVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGS 500
            .||:....|||::.|||. .||| |..|.|||:..|::.:..:  ..|:|.:|:.....:||..:
Zfish   385 CGGAPAAERGYFIQPTVFGDVKD-DMTIAREEIFGPVMQILKF--KSLEEVIERANDSKYGLAAA 446

  Fly   501 VFAQD---QNFIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLG 552
            ||.|:   .|:|.....|..|.:...||    .|:   |.|||....:|...:||
Zfish   447 VFTQNIDKANYISHGLRAGTVWINCYNV----FGV---QAPFGGYKASGIGRELG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	131/510 (26%)
aldh2.1	NP_956784.1	ALDH_F1AB_F2_RALDH1	30..510	CDD:143459	131/510 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810