DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and aldh2.2

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_998466.2	Gene:	aldh2.2 / 368239	ZFINID:	ZDB-GENE-030326-5	Length:	516	Species:	Danio rerio

Alignment Length:	530	Identity:	133/530 - (25%)
Similarity:	217/530 - (40%)	Gaps:	97/530 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VEHVPIVINGQEFQA--KEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEAQ-------VKW 134
            |.:..|.||.:...|  |:.|..:.| ...:.|.|.....:.    .:||:|:|.       ..|
Zfish    33 VHYNKIFINNEWHDAVSKKTFPTINP-ATGEIICHVAEGDKA----DVDKAVKAARDAFKLGSPW 92

  Fly   135 DKVRLSDR-------IDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQA-EMDVAELVDFMRIN- 190
            .::..|.|       .|..||.|..:|        ....|..||....: .:||..:|..||..
Zfish    93 RRMDASQRGLLLSRLADCIERDAAYLA--------ELETLDNGKPYAVSFSVDVPMVVKCMRYYA 149

  Fly   191 -----------PVFLRELANY------EPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANL 238
                       |:.    .||      |||                 |....|.|:||..:....
Zfish   150 GWADKWEGKTIPID----GNYFCYTRHEPI-----------------GVCGQIIPWNFPLLMQAW 193

  Fly   239 AYTPAL-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGIN 302
            ...||| .||:|:.|.::...|:..::...::|.|.|.||||.||....|..:.:..|..:..:.
Zfish   194 KLGPALATGNTVVMKVAEQTPLTALYIASLIKEVGFPAGVVNIVPGMGPTAGAAIASHMDVDKVA 258

  Fly   303 FTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKC 367
            |||::.|..::     |..:...|..::..|.|||:.:.:.|.|..|.||..:..|.|...||.|
Zfish   259 FTGSTDVGHLI-----QRASSASNLKKVTLELGGKSPNIILSDANMEEAVEQSHIALFFNQGQCC 318

  Fly   368 SSCSMLYVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAVINRRAYDRIYMWLRYID--QS 430
            .:.:..:|.||::...: |..:|...:.:| .|....::.....:|...:.::   |.||.  :.
Zfish   319 CAGTRTFVQESIYDEFV-ERSVERAKNRIV-GDPFDLNTEQGPQVNEDQFKKV---LGYISSGKR 378

  Fly   431 PSCQILVGGSCDKRRGYYVDPTVV-LVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQIN 494
            ...:::.||:....|||::.|||. .||| |..|.|||:..|::.:..:  ..|:|.:|:.....
Zfish   379 EGAKLMCGGAPAAERGYFIQPTVFGDVKD-DMTIAREEIFGPVMQILKF--KSLEEVIERANDSK 440

  Fly   495 HGLTGSVFAQD---QNFIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLGTPHS 556
            :||.|:||.||   .|:|.....|..|.:...||    .|:   |.|||....:|...::| .:.
Zfish   441 YGLAGAVFTQDIDKANYISHGLRAGTVWINCYNV----FGV---QAPFGGYKASGIGREMG-EYG 497

  Fly   557 LLRWTSPQVI 566
            |..:|..:.:
Zfish   498 LENYTEVKTV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	133/530 (25%)
aldh2.2	NP_998466.2	ALDH_F1AB_F2_RALDH1	30..510	CDD:143459	133/530 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910