Protein Alignment P5CDh2 and Aldh1l2

DIOPT Version :10

• Sequence 1: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001178707.2
• Gene: Aldh1l2 / 299699
• RGDID: 1309458
• Length: 923
• Species: Rattus norvegicus
• Alignment Length: 554
• Identity: 114/554 - (20%)
• Similarity: 212/554 - (38%)
• Gaps: 93/554 - (16%)

  Fly    53 EKLLQYDEGSKERTELETALLGVLNRVEHVPIVINGQEFQAK--EDFQQVLPYDIQQPIAHYGHA 115
            |..|..|..|||..|:...:        .....||||...|:  |.:..:.|.| ...:....:|
  Rat   422 EAELVVDYVSKEVNEMTVKM--------PYQCFINGQFVDAEDGETYATINPTD-GTTLCRVSYA 477

  Fly   116 HRVLIQMAIDKSVEA--QVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQAEM 178
            ....:..|:..:.:|  ..:|.::...||            ||..|.:  |.::.:    .|.|:
  Rat   478 SLADVDRAVAAAKDAFENGEWGRMNARDR------------GRLMYRL--ADLMEE----NQEEL 524

  Fly   179 DVAELVDFMRINPVFL-----------RELANYEPIRDIQNNCRNSMRLRGLSGF--------VA 224
            ...|.:|...:..:.|           |..|.:.....:.....|..|:....|.        .|
  Rat   525 ATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQVTKEPENQARIHDTLGMSSEEPKVVCA 589

  Fly   225 AISPFNFTGIAANLAYTPA---LMGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEET 286
            .|.|:|:.  ...||:..|   ..||:::.||:....|:.....:...:||.|.||:|.:|....
  Rat   590 IIIPWNYP--LMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELTVKAGFPKGVINIIPGSGG 652

  Fly   287 TFASVVTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETA 351
            .....::|||.:..:.|||:::|.|.:.:..|     ..|..::..|.|||:...:.|..|.:.|
  Rat   653 VAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCA-----VSNLKKVSLELGGKSPLIIFSDCELDKA 712

  Fly   352 VACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLV---VRQDATYCDSFCSAVIN 413
            |...:.|.|...|:.|.:...|:|.|::....:...:.||....:   :.:...:...      |
  Rat   713 VRMGMGAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ------N 771

  Fly   414 RRAYDRIYMWLRYIDQ--SPSCQILVGGSCDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVY 476
            .:|:  :...|:|.:.  .....::.||...:|.|::::|||....:....:.:||...||:.:.
  Rat   772 HKAH--LEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVIS 834

  Fly   477 VYPDHKLKETMEKVAQINHGLTGSVFAQDQN---FIEEAYDAFRVNVGNLNVNDKSTGLMVGQQP 538
            .:.:..:...:::.....:||...||.:|.:   ::.:..:|..|.:...|..|.:.       |
  Rat   835 KFQNGDIDGVLQRANNTEYGLASGVFTRDISKAMYVSDRLEAGTVFINTYNKTDVAA-------P 892

  Fly   539 FGAGHMTGTSDKLGTPHSLLRWTSPQVIKESYKT 572
            ||....:|....||          .:.:.|..||
  Rat   893 FGGVKQSGFGKDLG----------EEALNEYLKT 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:448367	112/550 (20%)
Aldh1l2	NP_001178707.2	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:425746
		ALDH_F1L_FTFDH	438..923	CDD:143458	107/538 (20%)