DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001178707.2	Gene:	Aldh1l2 / 299699	RGDID:	1309458	Length:	923	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	114/554 - (20%)
Similarity:	212/554 - (38%)	Gaps:	93/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EKLLQYDEGSKERTELETALLGVLNRVEHVPIVINGQEFQAK--EDFQQVLPYDIQQPIAHYGHA 115
            |..|..|..|||..|:...:        .....||||...|:  |.:..:.|.| ...:....:|
  Rat   422 EAELVVDYVSKEVNEMTVKM--------PYQCFINGQFVDAEDGETYATINPTD-GTTLCRVSYA 477

  Fly   116 HRVLIQMAIDKSVEA--QVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQAEM 178
            ....:..|:..:.:|  ..:|.::...||            ||..|.:  |.::.:    .|.|:
  Rat   478 SLADVDRAVAAAKDAFENGEWGRMNARDR------------GRLMYRL--ADLMEE----NQEEL 524

  Fly   179 DVAELVDFMRINPVFL-----------RELANYEPIRDIQNNCRNSMRLRGLSGF--------VA 224
            ...|.:|...:..:.|           |..|.:.....:.....|..|:....|.        .|
  Rat   525 ATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQVTKEPENQARIHDTLGMSSEEPKVVCA 589

  Fly   225 AISPFNFTGIAANLAYTPA---LMGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEET 286
            .|.|:|:.  ...||:..|   ..||:::.||:....|:.....:...:||.|.||:|.:|....
  Rat   590 IIIPWNYP--LMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELTVKAGFPKGVINIIPGSGG 652

  Fly   287 TFASVVTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETA 351
            .....::|||.:..:.|||:::|.|.:.:..|     ..|..::..|.|||:...:.|..|.:.|
  Rat   653 VAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCA-----VSNLKKVSLELGGKSPLIIFSDCELDKA 712

  Fly   352 VACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLV---VRQDATYCDSFCSAVIN 413
            |...:.|.|...|:.|.:...|:|.|::....:...:.||....:   :.:...:...      |
  Rat   713 VRMGMGAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ------N 771

  Fly   414 RRAYDRIYMWLRYIDQ--SPSCQILVGGSCDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVY 476
            .:|:  :...|:|.:.  .....::.||...:|.|::::|||....:....:.:||...||:.:.
  Rat   772 HKAH--LEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVIS 834

  Fly   477 VYPDHKLKETMEKVAQINHGLTGSVFAQDQN---FIEEAYDAFRVNVGNLNVNDKSTGLMVGQQP 538
            .:.:..:...:::.....:||...||.:|.:   ::.:..:|..|.:...|..|.:.       |
  Rat   835 KFQNGDIDGVLQRANNTEYGLASGVFTRDISKAMYVSDRLEAGTVFINTYNKTDVAA-------P 892

  Fly   539 FGAGHMTGTSDKLGTPHSLLRWTSPQVIKESYKT 572
            ||....:|....||          .:.:.|..||
  Rat   893 FGGVKQSGFGKDLG----------EEALNEYLKT 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	112/550 (20%)
Aldh1l2	NP_001178707.2	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:395435
		ALDH_F1L_FTFDH	438..923	CDD:143458	107/538 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900