DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and Aldh1b1

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001011975.1	Gene:	Aldh1b1 / 298079	RGDID:	1306737	Length:	519	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	133/573 - (23%)
Similarity:	239/573 - (41%)	Gaps:	110/573 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NMRSILPRLEASVKGGLVSVRSTSKRPELSEHFTLDEMVANEKLLQYDEGSKERTELETALLGVL 76
            |.|.::||| ..::|     |:||    .|....|...:.|.: ::|::
  Rat     3 NARFLVPRL-LCLQG-----RTTS----YSTAAALPNPIPNPE-IRYNQ---------------- 40

  Fly    77 NRVEHVPIVINGQEFQA--KEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEA---QVKWDK 136
                   :.||.:...|  |:.|..|.| ...:.|.|.....|..:.:|:..:.||   ...|.:
  Rat    41 -------LFINNEWHDAVSKKTFPTVNP-TTGEVIGHVAEGDRADVDLAVRAAREAFRLGSPWRR 97

  Fly   137 VRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKTLRQA-EMDVAELVDFMRINPVFLRELAN- 199
            :..|:|..:..|.|.|:. |.|..:.:...|..||..::: .:|:.|::...|    :|...|:
  Rat    98 MDASERGRLLNRLADLVE-RDRVYLASLETLDNGKPFQESYVLDLDEVIKVYR----YLAGWADK 157

  Fly   200 -----------------YEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPAL-MG 246
                             :||:                 |....|.|:||..:.......||| .|
  Rat   158 WHGKTIPMDGEHFCFTRHEPV-----------------GVCGQIIPWNFPLVMQGWKLAPALATG 205

  Fly   247 NSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTSTVLK 311
            |:|:.|.::...||..::...::|||.|.||||.:.....|..:.:.||..:..:.|||::.|..
  Rat   206 NTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHMDVDKVAFTGSTEVGH 270

  Fly   312 VLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYVP 376
            ::.:....:     |..|:..|.|||:...|.:.|:.:.||.....|.|...||.|.:.|..:|.
  Rat   271 LIQKAAGDS-----NLKRVTLELGGKSPSIVLADADMDHAVDQCHEALFFNMGQCCCAGSRTFVE 330

  Fly   377 ESLWQNHIREPLLEITASLVVRQ---DATYCDSFCSAVINRRAYDRIYMWLRYIDQSPSCQILVG 438
            ||::..     .||.|.....::   :....|:.....:::..:::|..::| :.|....::|.|
  Rat   331 ESIYHE-----FLERTVEKAKKRKVGNPFELDTQQGPQVDKEQFEKILGYIR-LGQKEGAKLLCG 389

  Fly   439 GSCDKRRGYYVDPTVV-LVKDLDNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGSVF 502
            |.....||:::.|||. .|:| |..|.|||:..|:..::.:  .|::|.:::.....:||..:||
  Rat   390 GERFGERGFFIKPTVFGNVQD-DMRIAREEIFGPVQPLFKF--KKIEEVIQRANNTRYGLAAAVF 451

  Fly   503 AQDQN---FIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLG 552
            .:|.:   :..:|..|..|.|...|:       :....|||....:|...:||
  Rat   452 TRDLDKALYFSQALQAGTVWVNTYNI-------VTCHTPFGGFKESGNGRELG 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	122/535 (23%)
Aldh1b1	NP_001011975.1	PLN02466	13..510	CDD:215259	128/562 (23%)
Aldh1b1	NP_001011975.1	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	122/533 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810