DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and Aldh1a7

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_036051.1	Gene:	Aldh1a7 / 26358	MGIID:	1347050	Length:	501	Species:	Mus musculus

Alignment Length:	540	Identity:	123/540 - (22%)
Similarity:	221/540 - (40%)	Gaps:	115/540 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RVEHVPIVINGQ--EFQAKEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVEA-----QV--K 133
            :::|..|.||.:  :..:.:.| .||....::.|.|.....:.    .:||:|:|     |:  .
Mouse    17 KIQHTKIFINNEWHDSVSSKKF-PVLNPATEEVICHVEEGDKA----DVDKAVKAARQAFQIGSP 76

  Fly   134 WDKVRLSDRIDIWERAAMLIAGRYRYNIIAATM--LGQGKTLRQA-----EMDVAELVDFM---- 187
            |..:..|:|..:..:.|.|:.   |..::.|||  :..||....|     |:.:..|..|.
Mouse    77 WRTMDASERGRLLNKLADLME---RDRLLLATMESMNAGKVFAHAYLLDVEISIKALQYFAGWAD 138

  Fly   188 RINPVFLRELANY------EPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPAL-M 245
            :|:...:....|.      |||                 |....|.|:|...|.......||| .
Mouse   139 KIHGQTIPSDGNIFTYTRREPI-----------------GVCGQIIPWNGPLIIFTWKLGPALSC 186

  Fly   246 GNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTSTVL 310
            ||:|:.||::...|:...:...::|||.|.||||.||....|....::.|..:..::|||::.|.
Mouse   187 GNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGGAISSHMDIDKVSFTGSTEVG 251

  Fly   311 KVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYV 375
            |::.:...::     |..|:..|.|||:...|.:.|:.::||....:..|.:.||.|.:.|.|:|
Mouse   252 KLIKEAAGKS-----NLKRVTLELGGKSPCIVFADADLDSAVEFAHQGVFFHQGQICVAASRLFV 311

  Fly   376 PESLWQNHIREPLLEITASLVVRQDATYC--DSFCSAV-----INRRAYDRIYMWLRYIDQSPSC 433
            .||::...:|..         |.:...|.  :...|.:     |::..:::| :.|....:....
Mouse   312 EESIYDEFVRRS---------VERAKKYILGNPLNSGINQGPQIDKEQHNKI-LGLIESGKKEGA 366

  Fly   434 QILVGGSCDKRRGYYVDPTVVLVKDLDNI-----ICREELLAPILGVYVYPDHKLKETMEKVAQI 493
            ::..||.....:|::|.|||     ..|:     |.:||:..|:..:..:  ..:.:.:::....
Mouse   367 KLECGGGRWGNKGFFVQPTV-----FSNVTDEMRIAKEEIFGPVQQIMKF--KSMDDVIKRANNT 424

  Fly   494 NHGLTGSVFAQDQNFIEEAYDAFRVNVGNLNVNDKSTGLMVG------------QQPFGAGHMTG 546
            .:||...||.:|   :::|...             |:.|..|            |.|||...|:|
Mouse   425 TYGLAAGVFTKD---LDKAITV-------------SSALQAGMVWVNCYLAVPVQCPFGGFKMSG 473

  Fly   547 TSDKLGTPHSLLRWTSPQVI 566
            ...:|| .|.|..:|..:.:
Mouse   474 NGRELG-EHGLYEYTELKTV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	123/540 (23%)
Aldh1a7	NP_036051.1	ALDH_F1AB_F2_RALDH1	15..494	CDD:143459	123/540 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810