DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and SPBC24C6.04

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001342759.1	Gene:	SPBC24C6.04 / 2540387	PomBaseID:	SPBC24C6.04	Length:	548	Species:	Schizosaccharomyces pombe

Alignment Length:	541	Identity:	211/541 - (39%)
Similarity:	317/541 - (58%)	Gaps:	18/541 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VANEKLLQYDEGSKER-------TELETALLGVLNRVEHVPIVINGQEFQAKEDFQQVLPYDIQQ 107
            :.||....|...|.:|       .|||..|      ...:|::|:|:|.:.....:|..|::.::
pombe    12 IKNEPPKHYGPNSADREGIVKAYKELEAEL------PVTIPVIIDGKEVETNTIGEQRCPFEHKK 70

  Fly   108 PIAHYGHAHRVLIQMAIDKSVEAQVKWDKVRLSDRIDIWERAAMLIAGRYRYNIIAATMLGQGKT 172
            .:|.|..|....::.||:.::..:..|:.:..:||..|:.:||.||:.:|||.::||||:||||.
pombe    71 VVARYHRAGAKHVEDAIEAALRGKKVWESLPFADRSAIFLKAAHLISTKYRYKLMAATMIGQGKN 135

  Fly   173 LRQAEMDVA-ELVDFMRINPVFLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTGIAA 236
            :.|||:|.. |::||:|.|..:..||...:|..:.. ...|.|..|.|.|||.||:|||||.||.
pombe   136 IWQAEIDAGMEIIDFLRFNTKYASELYASQPPENTP-GVWNRMEYRPLEGFVYAITPFNFTAIAG 199

  Fly   237 NLAYTPALMGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPKLAGI 301
            |||..|.||||.|:.||||.|:||:|.|::..||||:|.|.:.|:|.:....:.|...||:.||:
pombe   200 NLAAAPLLMGNVVLMKPSDHAVLSSYIVYQIFREAGLPAGALQFIPGDAVEVSKVCFNHPEFAGL 264

  Fly   302 NFTGTSTVLKVLWQLVAQNI--NFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEYAG 364
            :|||::.|.:.||..:.:|:  ..|:.||::|||.||||||.||||||.::||...:||||||.|
pombe   265 HFTGSTAVFRSLWGTIGENVANGKYRTYPKIVGETGGKNFHLVHSSAEIKSAVVNAVRAAFEYQG 329

  Fly   365 QKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAVINRRAYDRIYMWLRYIDQ 429
            ||||:.|.|||.:..|:|..|:.|.:...||.|....|...:|...||::.:::::...|.....
pombe   330 QKCSALSRLYVSKYAWENGFRDELTKQVKSLKVGAPLTDFANFVGPVIHQASFNKLKKVLESAAS 394

  Fly   430 SPSCQILVGGSCDKRRGYYVDPTVVLVKDLDNIICREELLAPILGVYVYPDHKLKETMEKV-AQI 493
            ....::|.||..|...|::|:|||:|.|:..:.|...||..|:|.||||.|..|....:.: ...
pombe   395 DSEIEVLAGGKADDSEGFFVEPTVLLSKNPKHDIFVNELFGPVLSVYVYEDDNLDAVCDLIDTTT 459

  Fly   494 NHGLTGSVFAQDQNFIEEAYDAFRVNVGNLNVNDKSTGLMVGQQPFGAGHMTGTSDKLGTPHSLL 558
            .:|||||:||||:..:.:..|..|...||..:|||.||.:||:||||....:||:||.|:...|.
pombe   460 PYGLTGSIFAQDRVVVRKLTDRLRNAAGNFYINDKCTGAVVGEQPFGGARASGTNDKAGSGMILS 524

  Fly   559 RWTSPQVIKESYKTHRNIFYP 579
            |:.||:.||:::....::.||
pombe   525 RFVSPRSIKDTFAYADSVLYP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	209/530 (39%)
SPBC24C6.04	NP_001342759.1	ALDH_F4-17_P5CDH	12..537	CDD:143441	209/531 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	421	1.000	Domainoid score	I86
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I284
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004722
OrthoInspector	1	1.000	-	-		otm47358
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42862
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3320
TreeFam	1	0.960	-	-
	9	8.920