DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh2 and ALDH1A1

DIOPT Version :9

Sequence 1:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_000680.2	Gene:	ALDH1A1 / 216	HGNCID:	402	Length:	501	Species:	Homo sapiens

Alignment Length:	528	Identity:	130/528 - (24%)
Similarity:	220/528 - (41%)	Gaps:	118/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RVEHVPIVIN--------GQEF-----QAKEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVE 129
            ::::..|.||        |::|     ..:|:..||...|.:.                :||:|:
Human    17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKED----------------VDKAVK 65

  Fly   130 A-----QV--KWDKVRLSDR-------IDIWERAAMLIA-------GRYRYNIIAATMLGQGKTL 173
            |     |:  .|..:..|:|       .|:.||..:|:|       |:...|.....:.|..|||
Human    66 AARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTL 130

  Fly   174 RQAEMDVAELVDFM--RINPV---FLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTG 233
            |..    |...|.:  |..|:   |. ....:|||                 |....|.|:||..
Human   131 RYC----AGWADKIQGRTIPIDGNFF-TYTRHEPI-----------------GVCGQIIPWNFPL 173

  Fly   234 IAANLAYTPAL-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPK 297
            :.......||| .||:|:.||::...|:...|...::|||.|.||||.||....|..:.::.|..
Human   174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD 238

  Fly   298 LAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEY 362
            :..:.|||::.|.|::.:...::     |..|:..|.|||:...|.:.|:.:.||.......|.:
Human   239 IDKVAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYH 298

  Fly   363 AGQKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAV-----INRRAYDRIYM 422
            .||.|.:.|.::|.||::...:|.. :|.....::....|      ..|     |::..||:|
Human   299 QGQCCIAASRIFVEESIYDEFVRRS-VERAKKYILGNPLT------PGVTQGPQIDKEQYDKI-- 354

  Fly   423 WLRYID--QSPSCQILVGGSCDKRRGYYVDPTVVLVKDLDNI-----ICREELLAPILGVYVYPD 480
             |..|:  :....::..||.....:||:|.|||     ..|:     |.:||:..|:..:..:
Human   355 -LDLIESGKKEGAKLECGGGPWGNKGYFVQPTV-----FSNVTDEMRIAKEEIFGPVQQIMKF-- 411

  Fly   481 HKLKETMEKVAQINHGLTGSVFAQDQNFIEEAYD-AFRVNVGNLNVNDKSTGLMVGQQPFGAGHM 544
            ..|.:.:::.....:||:..||.:|   |::|.. :..:..|.:.||  ..|::..|.|||...|
Human   412 KSLDDVIKRANNTFYGLSAGVFTKD---IDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471

  Fly   545 TGTSDKLG 552
            :|...:||
Human   472 SGNGRELG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	130/528 (25%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	130/528 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810