Protein Alignment P5CDh2 and ALDH1A1

DIOPT Version :10

• Sequence 1: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_000680.2
• Gene: ALDH1A1 / 216
• HGNCID: 402
• Length: 501
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 130/528 - (24%)
• Similarity: 220/528 - (41%)
• Gaps: 118/528 - (22%)

  Fly    78 RVEHVPIVIN--------GQEF-----QAKEDFQQVLPYDIQQPIAHYGHAHRVLIQMAIDKSVE 129
            ::::..|.||        |::|     ..:|:..||...|.:.                :||:|:
Human    17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKED----------------VDKAVK 65

  Fly   130 A-----QV--KWDKVRLSDR-------IDIWERAAMLIA-------GRYRYNIIAATMLGQGKTL 173
            |     |:  .|..:..|:|       .|:.||..:|:|       |:...|.....:.|..|||
Human    66 AARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTL 130

  Fly   174 RQAEMDVAELVDFM--RINPV---FLRELANYEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTG 233
            |..    |...|.:  |..|:   |. ....:|||                 |....|.|:||..
Human   131 RYC----AGWADKIQGRTIPIDGNFF-TYTRHEPI-----------------GVCGQIIPWNFPL 173

  Fly   234 IAANLAYTPAL-MGNSVIWKPSDSAILSNYFVFKALREAGVPDGVVNFVPAEETTFASVVTQHPK 297
            :.......||| .||:|:.||::...|:...|...::|||.|.||||.||....|..:.::.|..
Human   174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD 238

  Fly   298 LAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGGKNFHFVHSSAEPETAVACTIRAAFEY 362
            :..:.|||::.|.|::.:...::     |..|:..|.|||:...|.:.|:.:.||.......|.:
Human   239 IDKVAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYH 298

  Fly   363 AGQKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDATYCDSFCSAV-----INRRAYDRIYM 422
            .||.|.:.|.::|.||::...:|.. :|.....::....|      ..|     |::..||:|
Human   299 QGQCCIAASRIFVEESIYDEFVRRS-VERAKKYILGNPLT------PGVTQGPQIDKEQYDKI-- 354

  Fly   423 WLRYID--QSPSCQILVGGSCDKRRGYYVDPTVVLVKDLDNI-----ICREELLAPILGVYVYPD 480
             |..|:  :....::..||.....:||:|.|||     ..|:     |.:||:..|:..:..:
Human   355 -LDLIESGKKEGAKLECGGGPWGNKGYFVQPTV-----FSNVTDEMRIAKEEIFGPVQQIMKF-- 411

  Fly   481 HKLKETMEKVAQINHGLTGSVFAQDQNFIEEAYD-AFRVNVGNLNVNDKSTGLMVGQQPFGAGHM 544
            ..|.:.:::.....:||:..||.:|   |::|.. :..:..|.:.||  ..|::..|.|||...|
Human   412 KSLDDVIKRANNTFYGLSAGVFTKD---IDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471

  Fly   545 TGTSDKLG 552
            :|...:||
Human   472 SGNGRELG 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:448367	130/528 (25%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	130/528 (25%)
		Mediates interaction with PRMT3. /evidence=ECO:0000269|PubMed:33495566	336..501		41/165 (25%)